FOXO3 (forkhead box O3A)

1998-04-01   Olivier Bernard  

Unite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France

Identity

HGNC
FOXO3
LOCATION
6q21
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
2309
ALIAS
AF6q21,FKHRL1,FKHRL1P2,FOXO2,FOXO3A
FUSION GENES
Show Gene Fusions

DNA/RNA

Transcription

6 kb transcript with a 3.2 kb mRNA complete cds; coding sequence: CDS 925..2946

Proteins

Atlas Image

Description

673 amino acids; NH2 -- similarity region with AFX and FKHR -- Forkhead motif -- COOH

Expression

wide

Localisation

nuclear (potential)

Function

may be a transcription regulator

Homology

AFX, involved in the t(X;11)(q13;q23), and FHKR, involved in rabdomyosarcoma; with also a similar breakpoint location within the forkhead motif

Implicated in

Entity name
t(6;11)(q21;q23)/AML --> KMT2A - FOXO3
Disease
treatment related AML, M5 type
Hybrid gene
5 MLL - 3 AF6q2
Fusion protein
240 kDa protein with about 1400 amino acids from N-term MLL fused to 446 amino acids from AF6q21 C-term; the reciprocal may be expressed

Article Bibliography

Pubmed IDLast YearTitleAuthors
94794911998Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.Anderson MJ et al
93450571997AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.Hillion J et al

Other Information

Locus ID:

NCBI: 2309
MIM: 602681
HGNC: 3821
Ensembl: ENSG00000118689

Variants:

dbSNP: 2309
ClinVar: 2309
TCGA: ENSG00000118689
COSMIC: FOXO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118689ENST00000343882O43524
ENSG00000118689ENST00000406360O43524
ENSG00000118689ENST00000540898O43524

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Endometrial cancerKEGGko05213
Non-small cell lung cancerKEGGko05223
Endometrial cancerKEGGhsa05213
Non-small cell lung cancerKEGGhsa05223
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
FoxO signaling pathwayKEGGhsa04068
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
PI3K-Akt signalingKEGGhsa_M00676
PI3K-Akt signalingKEGGM00676
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
PI3K/AKT Signaling in CancerREACTOMER-HSA-2219528
Constitutive Signaling by AKT1 E17K in CancerREACTOMER-HSA-5674400
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
AKT phosphorylates targets in the nucleusREACTOMER-HSA-198693
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370877182024The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a.1
378572672024Genetic Profile of FOXO3 Single-Nucleotide Polymorphism in Colorectal Cancer Patients.1
380093162024FOXO3 longevity genotype attenuates the impact of hypertension on cerebral microinfarct risk.1
380495652024FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis.2
382175402024ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.0
382707192024FOXO3a-interacting proteins' involvement in cancer: a review.0
382862712024FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines.0
383325742024Helicobacter pylori CagA protein induces gastric cancer stem cell-like properties through the Akt/FOXO3a axis.2
383628402024EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway.0
384703672024CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis.1
386081232024The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer.0
386301492024circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.0
386361972024FOXO3a deregulation in uterine smooth muscle tumors.0
370877182024The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a.1
378572672024Genetic Profile of FOXO3 Single-Nucleotide Polymorphism in Colorectal Cancer Patients.1

Citation

Olivier Bernard

FOXO3 (forkhead box O3A)

Atlas Genet Cytogenet Oncol Haematol. 1998-04-01

Online version: http://atlasgeneticsoncology.org/gene/125/css/deep-insight-explorer/hgnc