ABL2 (Abelson homolog 2)

2000-02-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
1q25.2
IMAGE
Atlas Image
LEGEND
ABL2 (1q25) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
ABLL,ARG
FUSION GENES

DNA/RNA

Transcription

alternate splicing in 5 prime; 3.8 kb mRNA; ORF: 3548 bp

Proteins

Description

1182 amino acids; 128 kDa; comprises SH3 and SH2 domains, a protein tyrosine kinase domain, a nuclear localization domain

Function

cytoplasmic tyrosine kinase

Homology

SRC homology; closely related to ABL1

Implicated in

Entity name
Disease
acute non lymphocytic leukemia
Fusion protein
the fusion protein is composed of the HLH oligomerization domain of ETV6 and the SH2, SH3, and protein tyrosine kinase domains of ABL2

Article Bibliography

Pubmed IDLast YearTitleAuthors
105900831999The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts.Cazzaniga G et al
37872601986A novel human gene closely related to the abl proto-oncogene.Kruh GD et al
21985711990The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.Kruh GD et al
25677011989Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross.Seldin MF et al

Other Information

Locus ID:

NCBI: 27
MIM: 164690
HGNC: 77
Ensembl: ENSG00000143322

Variants:

dbSNP: 27
ClinVar: 27
TCGA: ENSG00000143322
COSMIC: ABL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143322ENST00000344730P42684
ENSG00000143322ENST00000367623P42684
ENSG00000143322ENST00000392043P42684
ENSG00000143322ENST00000502732P42684
ENSG00000143322ENST00000504405P42684
ENSG00000143322ENST00000507173P42684
ENSG00000143322ENST00000511413P42684
ENSG00000143322ENST00000512653P42684

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
ErbB signaling pathwayKEGGhsa04012
Viral myocarditisKEGGhsa05416
Ras signaling pathwayKEGGhsa04014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374799012024Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.0
374799012024Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.0
366890652023Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization.1
366890652023Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization.1
347870582022CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis.7
347870582022CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis.7
335509412021microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2.2
337226552021Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2.7
337703212021Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.15
341440392021Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.3
335509412021microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2.2
337226552021Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2.7
337703212021Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.15
341440392021Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.3
320351332020Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells.13

Citation

Jean-Loup Huret

ABL2 (Abelson homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2000-02-01

Online version: http://atlasgeneticsoncology.org/gene/226/abl2-(abelson-homolog-2)