LIN28B (lin-28 homolog B (C. elegans))
2011-07-01 Yung-Ming Jeng AffiliationDepartment of Biochemistry, Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
DNA/RNA
Description
The gene spans over 125 kb on plus strand; 4 exons.
Transcription
The gene is mainly expressed in fetal tissues and not expressed in adult tissue and reexpressed in cancer tissue.
Proteins
Description
Lin28B is an oncofetal RNA-binding protein. Lin-28B protein consists of two domains that contain RNA-binding motif: the N-terminal cold shock domain and a pair of retroviral-type CCHC zinc fingers. It inhibits biosynthesis of let-7 microRNA through binding to the 5-GGAG-3 motif in the terminal loop of pre-let-7 and promoting terminal uridylation of let-7 precusor by TUTase4. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation.
Expression
Cytoplasm.
Function
It inhibits biosynthesis of let-7 microRNA through promoting terminal uridylation of let-7 precusor by TUTase4.
Homology
Lin28
Mutations
Note
No somatic mutation of Lin28B was identified in cancer.
Implicated in
Entity name
Hepatocellular carcinoma
Note
Lin28B expression is more frequently noted in high-grade hepatocellular carcinoma with high alpha-fetoprotein levels. Knockdown of Lin28B by RNA interference in the HCC cell line suppressed proliferation in vitro and reduced in vivo tumor growth in NOD/SCID mice. In contrast, overexpression of Lin28B in the HCC cell line enhanced tumorigenicity. Overexpression of Lin28B also induced epithelial-mesenchymal transition in HA22T cells and hence, invasion capacity.
Entity name
Colorectal cancer
Note
Entity name
Ovarian cancer
Note
Lin28B is overexpressed in high grade serous ovarian cancer. Pleomorphism in Lin28B promoter region is associated with susceptibility to epithelium ovarian cancer. Patients with high Lin28B ovarian cancer had shorter progression-free and overall survival than those with low Lin28B ovarian cancer.
Entity name
Age at menarche
Note
A sequence variation in Lin28B is identified as the SNP most significant associated with age at menarche in one genome wide study. Besides, a meta-analysis of 32 genome-wide association studies in 87802 women found polymorphism of Lin28B is strongly associated with age at menarche. Knockout mice of Lin28B also show delay in puberty onset.
Entity name
Body height
Note
A LIN28B SNP, rs314277, is associated with final body height.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 19448621 | 2009 | Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. | He C et al |
| 21533284 | 2011 | Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. | Helland Å et al |
| 18951094 | 2008 | Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. | Heo I et al |
| 21512136 | 2011 | LIN28B promotes colon cancer progression and metastasis. | King CE et al |
| 21625210 | 2011 | LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms. | King CE et al |
| 19477633 | 2009 | Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II. | Lu L et al |
| 19483683 | 2009 | Lin28 promotes transformation and is associated with advanced human malignancies. | Viswanathan SR et al |
Other Information
Locus ID:
NCBI: 389421
MIM: 611044
HGNC: 32207
Ensembl: ENSG00000187772
Variants:
dbSNP: 389421
ClinVar: 389421
TCGA: ENSG00000187772
COSMIC: LIN28B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187772 | ENST00000345080 | Q6ZN17 |
| ENSG00000187772 | ENST00000635857 | A0A1B0GTK2 |
| ENSG00000187772 | ENST00000637759 | A0A1B0GVD3 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38216964 | 2024 | Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28. | 2 |
| 38305285 | 2024 | MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells. | 0 |
| 38321106 | 2024 | LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression. | 0 |
| 38338881 | 2024 | A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway in LIN28B-Dependent Cancer Cells. | 0 |
| 38612395 | 2024 | Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. | 0 |
| 38704454 | 2024 | Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6. | 0 |
| 38216964 | 2024 | Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28. | 2 |
| 38305285 | 2024 | MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells. | 0 |
| 38321106 | 2024 | LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression. | 0 |
| 38338881 | 2024 | A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway in LIN28B-Dependent Cancer Cells. | 0 |
| 38612395 | 2024 | Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. | 0 |
| 38704454 | 2024 | Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6. | 0 |
| 36649308 | 2023 | LIN28 expression and function in medulloblastoma. | 2 |
| 36660796 | 2023 | Semaphorin 3A inhibits tumor progression via the downregulation of Lin28B in ovarian cancer. | 1 |
| 36828304 | 2023 | Association of the KISS1, LIN28B, VDR and ERα gene polymorphisms with early and fast puberty in Chinese girls. | 0 |
Citation
Yung-Ming Jeng
LIN28B (lin-28 homolog B (C. elegans))
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/45723
