TCTA (T-cell leukemia translocation-associated gene)
1998-03-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
DNA diagram
Transcription
2.1 kb mRNA
Proteins
Description
103 amino acids; 11 kDa; rich in hydrophobic amino acids
(residues 41-61)
Expression
wide, especially in kidneys
Localisation
may be a membrane associated protein, as there is a
hydrophobic domain
Function
unknown
Homology
none is known
Implicated in
Disease
T-cell ALL
Hybrid gene
head to head orientation of TAL1 and TCTA
Fusion protein
no fusion protein, but possibly promoter exchange and gene
disregulation
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7728759 | 1995 | Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. | Aplan PD et al |
Other Information
Locus ID:
NCBI: 6988
MIM: 600690
HGNC: 11692
Ensembl: ENSG00000145022
Variants:
dbSNP: 6988
ClinVar: 6988
TCGA: ENSG00000145022
COSMIC: TCTA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000145022 | ENST00000273590 | P57738 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 19692168 | 2010 | Genetic susceptibility to distinct bladder cancer subphenotypes. | 30 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19692168 | 2010 | Genetic susceptibility to distinct bladder cancer subphenotypes. | 30 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19560569 | 2009 | T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. | 8 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 20046013 | 2009 | [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]. | 1 |
| 19560569 | 2009 | T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. | 8 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 20046013 | 2009 | [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]. | 1 |
| 22174563 | 2004 | Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. | 0 |
| 22174563 | 2004 | Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. | 0 |
Citation
Jean-Loup Huret
TCTA (T-cell leukemia translocation-associated gene)
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/gene/58/gene-explorer/tumors-explorer/gene-fusions-explorer/
Historical Card
1998-01-01 TCTA (T-cell leukemia translocation-associated gene) by Jean-Loup Huret Affiliation
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
