HOXA9 (homeobox A9)
1998-01-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
7p15.2
LOCUSID
ALIAS
ABD-B,HOX1,HOX1.7,HOX1G
FUSION GENES
Proteins
Description
129 amino acids; DNA binding domain (homeobox) in C-term
Localisation
nuclear
Function
sequence specific transcription factor; role during embryonic
development (patterning); HOX genes are also expressed in adult tissues,
including blood cells; probable role in blood cell differenciation
Homology
with class 1 homeodomain proteins
Implicated in
Entity name
Disease
M2-M4 AML mostly; occasionally: CML-like cases
Prognosis
mean survival: 15 mths
Cytogenetics
sole anomaly most often
Hybrid gene
5 NUP98 - 3 HOXA9
Fusion protein
fuses the GLFG repeat domains of NUP98 to the HOXA9 homeobox
Breakpoints
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8563754 | 1996 | The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. | Borrow J et al |
| 9058712 | 1997 | Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. | Lawrence HJ et al |
| 8563753 | 1996 | Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. | Nakamura T et al |
Other Information
Locus ID:
NCBI: 3205
MIM: 142956
HGNC: 5109
Ensembl: ENSG00000078399
Variants:
dbSNP: 3205
ClinVar: 3205
TCGA: ENSG00000078399
COSMIC: HOXA9
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000078399 | ENST00000343483 | P31269 |
| ENSG00000078399 | ENST00000396345 | A8MVF3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transcriptional misregulation in cancer | KEGG | ko05202 |
| Transcriptional misregulation in cancer | KEGG | hsa05202 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38216972 | 2024 | RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9. | 0 |
| 38904676 | 2024 | Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis. | 0 |
| 38216972 | 2024 | RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9. | 0 |
| 38904676 | 2024 | Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis. | 0 |
| 34743404 | 2023 | Molecular regulators of HOXA9 in acute myeloid leukemia. | 14 |
| 36577137 | 2023 | HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. | 5 |
| 34743404 | 2023 | Molecular regulators of HOXA9 in acute myeloid leukemia. | 14 |
| 36577137 | 2023 | HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. | 5 |
| 34850551 | 2022 | ALKBH5-mediated m6A modification of lncRNA KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9. | 19 |
| 34913472 | 2022 | Circular RNA circFADS2 inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-766-3p/HOXA9 axis. | 3 |
| 35372588 | 2022 | Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer. | 7 |
| 35743243 | 2022 | HOXA9 Overexpression Contributes to Stem Cell Overpopulation That Drives Development and Growth of Colorectal Cancer. | 5 |
| 35830966 | 2022 | Downregulation of hsa-miR-548d-3p and overexpression of HOXA9 in diffuse large B-cell lymphoma patients and the risk of R-CHOP chemotherapy resistance and disease progression. | 0 |
| 36065412 | 2022 | circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis. | 2 |
| 36192425 | 2022 | HOXA9 has the hallmarks of a biological switch with implications in blood cancers. | 6 |
Citation
Jean-Loup Huret
HOXA9 (homeobox A9)
Atlas Genet Cytogenet Oncol Haematol. 1998-01-01
Online version: http://atlasgeneticsoncology.org/gene/61/gene-explorer/cancer-prone-explorer/cookies-notice
