t(1;7)(p32;q34) TRB/TAL1
t(1;14)(p32;q11) TRA/TAL11
p32 rearrangements

1998-01-01   Jean-Loup Huret  , Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

T- cell ALL

Epidemiology

rare findings; t(1;14) is found in approximately 3% of T-ALL;t(1;7) is rarer (status 3: < 5 cases); however, TAL1 rearrangements, alltogether (being mostly submicroscopic deletions without visible 1p32involvement), occurs in 15-25% of T-ALL; male predominance (as is classicalin T-cell ALL)

Clinics

organomegaly; high WBC (median 200X 109/l)

Genes Involved and Proteins

Gene name
TAL1 (T-cell acute leukemia 1)
Location
1p33
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain;forms heterodimers; transcription factor; role in haematopoietic celldifferentiation
Gene name
TRA (T cell Receptor Alpha)
Location
14q11.2
Gene name
TRB (T cell Receptor Beta)
Location
7q34

Result of the Chromosomal Anomaly

Atlas Image

Description

in most cases (breakpoints between exons 2B and 3 of TAL1), 3TAL1 joins variable and diversity segments of TCR on der(14); in the fewcases where the breakpoint is within exon 6 of TAL1 or 3 from it,constant segments of TCR join TAL1 on der(1)

Bibliography

No bibliography items were found for this article.

Summary

Note

the two chromosome anomalies are variants of each other, and theyshare identical features
Atlas Image
t(1;14)(p32;q11) G-banding (top two) and fluorescence in situ hybridization with LSI TRA/TRD break-apart probe (Vysis, Abott Molecular, US) revealing juxtaposition of telomeric gene sequences (green) from chromosome 14 to der(1) chromosome as a result of the translocation - Courtesy Adriana Zamecnikova; t(1;14)(p32;q11) G-banding (middle) - Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services; and t(1;14)(p32;q11) R-banding (bottom) - Courtesy Isabelle Radford-Weiss.

Citation

Jean-Loup Huret ; Jean-Loup Huret

t(1;7)(p32;q34) TRB/TAL1
t(1;14)(p32;q11) TRA/TAL11
p32 rearrangements

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1047/1p32-rearrangements