t(1;3)(p32;p21) TCTA/TAL1
1998-03-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
T-cell ALL
Genes Involved and Proteins
Gene name
TAL1 (T-cell acute leukemia 1)
Location
1p33
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain;cforms heterodimers; transcription factor; role in haematopoietic celldifferentiation
Gene name
TCTA (T-cell leukemia translocation-associated gene)
Location
3p21.31
Protein description
contains a hydrophobic domain; may be a membrane
Protein description
associated protein
Result of the Chromosomal Anomaly
Description
TCTA and TAL1 are in opposite directionit may be that the promoting regions from TCTA disregulate TAL1expression
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7728759 | 1995 | Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. | Aplan PD et al |
| 1402676 | 1992 | Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. | Aplan PD et al |
Summary
Fusion gene
TCTA/TAL1 TCTA (3p21.31) TAL1 (1p33) M t(1;3)(p33;p21)
Citation
Jean-Loup Huret
t(1;3)(p32;p21) TCTA/TAL1
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/haematological/1108/gene-explorer/new-content/tumors-explorer/
