1.Kuwait Cancer Control Center, Kuwait email@example.com.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. To date, numerous PDGFRB fusion partners have been identified, with the vast majority being reported only in sporadic cases. Although PDGFRB fusions are rare, their identification is important in order to identify patients in whom targeted therapy with tyrosine kinase inhibitors is likely to be successful.
t(1;5)(q21;q32) PDE4DIP/PDGFRBt(1;5)(q21-23;q32) TPM3/PDGFRBt(1;5)(q21-23;q31-33)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/haematological/1115/t(1;5)(q21-23;q31-33)
2006-04-01 t(1;5)(q21;q32) PDE4DIP/PDGFRBt(1;5)(q21-23;q32) TPM3/PDGFRBt(1;5)(q21-23;q31-33) by Jean-Loup Huret