t(3;14)(q27;q32) HSP90AA1/BCL6

2013-01-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Non Hodgkin lymphoma


Four cases available to date: a case of primary gastric lymphoma (Xu et al., 2000); a gastric diffuse large B-cell lymphoma with residual MALT lymphoma (DLCLML) case (Chen et al., 2006), a case of primary central nervous system lymphoma (PCNSL, a diffuse large B cell lymphoma confined to the brain) (Montesinos-Rongen et al., 2003), and another lymphoma case (Akasaka et al., 2000).

Genes Involved and Proteins

Gene name
BCL6 (B-Cell Lymphoma 6)
Protein description
706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003). Role in germinal centers of lymphoid follicles. BCL6 prevents ATM and TP53 to induce apoptosis in response to DNA rearrangements such as somatic hypermutation and class switch recombination. Therefore essential for normal B cell development.
Gene name
HSP90AA1 (heat shock protein 90 alpha family class A member 1)
Protein description
HSP90AA1 is also known as HSP90. Molecular chaperone. Possesses an ATP binding site with intrinsic ATPase activity that regulates its conformation. Promotes the maturation, structural maintenance and regulation of specific target proteins called client proteins. Maintains protein homeostasis. HSP90AA1/HSP90 interacts with regions of client proteins where protein folding clefts merge. Folding clefts are a general topological feature of proteins in native conformation, and many of these hydrophobic clefts, must open to permit access of ligands. HSP90AA1/HSP90 stabilizes the open cleft, impeding further unfolding and Hsp70-dependent ubiquitination (Pratt et al., 2010). HSP90AA1/HSP90 and its associated co-chaperones facilitate a precise and efficient working environment beneficial for telomere function (DeZwaan and Freeman, 2010). HSP90AA1/HSP90 is exploited by cancer cells to support the activated and/or metastable forms of oncoproteins, and to buffer cellular stresses induced by the malignancy. Hsp90 is often overexpressed in cancer cells (Neckers and Workman, 2012).

Result of the Chromosomal Anomaly


The break occurs in HSP90AA1 intron 1, resulting in the exchange of the first non-coding exons of HSP90AA1 and BCL6.


Pubmed IDLast YearTitleAuthors
108111032000Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays.Akasaka H et al
125550642003Ambivalent role of BCL6 in cell survival and transformation.Albagli-Curiel O et al
167726022006High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma.Chen YW et al
202368252010HSP90 manages the ends.DeZwaan DC et al
146557582003Molecular characterization of BCL6 breakpoints in primary diffuse large B-cell lymphomas of the central nervous system identifies GAPD as novel translocation partner.Montesinos-Rongen M et al
222159072012Hsp90 molecular chaperone inhibitors: are we there yet?Neckers L et al
204040452010Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.Pratt WB et al
105645882000Identification and characterization of BCL6 translocation partner genes in primary gastric high-grade B-cell lymphoma: heat shock protein 89 alpha is a novel fusion partner gene of BCL6.Xu WS et al



Most of the t(3;14)(q27;q32) where molecular genetics studies were performed showed the involvement of IGH@ and BCL6. It is unknown if the prognoses are different.


Jean-Loup Huret

t(3;14)(q27;q32) HSP90AA1/BCL6

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1356/t(3;14)(q27;q32)