Abstract
Review on der(8;17)(q10;q10), with data on clinics.
Clinics and Pathology
Disease
Lymphoid and myeloid malignancies. All lymphoid cases were B Lineage. There were 5 cases of chronic lymphocytic leukemia (CLL) (Döhner et al., 1995; Geisler et al., 1997; Adeyinka et al., 2007; Tang et al., 2013), 1 case of B-prolymphocytic leukemia (Schlette et al., 2001), and 1 case of Waldenstrom macroglobulinemia (Wong 2003). There were also 2 myeloid cases; one acute myeloblastic leukemia without maturation (M1-AML) and one acute myeloblastic leukemia with maturation (M2-AML) (respectively Kim et al., 2001 and Mrózek et al., 2002).
Note
der(8;17)(q10;q10) is also a recurrent abnormality in adenocarcinoma of the large intestine.
Epidemiology
The 5 chronic lymphocytic leukemia cases were male patients, aged 50, 84, 92, ?, ?. The B-prolymphocytic leukemia case was a male patient, the Waldenstrom case a female patient aged 80 years, the AMLs cases a male and a female patient aged 68 years.
Prognosis
In only one chronic lymphocytic leukemia case was the survival noted: 52 months of treatment-free survival (Tang et al., 2013).
Cytogenetics
Note
A der(8;17)(q10;q10) is an unbalanced translocation, with 8p and 17 deletions.
Cytogenetics morphological
The der(8;17)(q10;q10) was the sole abnormality in 2 CLL cases, and the sole abnormality within a sideline in the Waldenstrom case (an i(17q) was found in another subclone). A t(14;18)(q32;q21) was present in 2 CLL cases; +12, del(13q), and a complex karyotype were found in 1 CLL case each. The B-prolymphocytic leukemia also had del(7q), del(11q). The 2 AMLs had a del(5q), and a complex karyotype, the M1-AML also presented with del(3p), and the M2-AML with t(10;16)(q22;p13) KAT6B/CREBBP, +19.
Genes Involved and Proteins
Result of the Chromosomal Anomaly
Oncogenesis
Genes implicated in oncogenesis in these cases are unknown. Nevertheless it should be noted that the chromosome abnormality results in TP53 deletion.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 17321329 | 2007 | Loss of 17p is a major consequence of whole-arm chromosome translocations in hematologic malignancies. | Adeyinka A et al |
| 7888675 | 1995 | p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. | Döhner H et al |
| 9444933 | 1997 | In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients. | Geisler CH et al |
| 11343775 | 2001 | The application of comparative genomic hybridization as an additional tool in the chromosome analysis of acute myeloid leukemia and myelodysplastic syndromes. | Kim MH et al |
| 11979548 | 2002 | Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q. | Mrózek K et al |
| 11293906 | 2001 | Mature B-cell leukemias with more than 55% prolymphocytes. A heterogeneous group that includes an unusual variant of mantle cell lymphoma. | Schlette E et al |
| 23084581 | 2013 | Chronic lymphocytic leukemia with t(14;18)(q32;q21). | Tang G et al |
| 12581904 | 2003 | Waldenström macroglobulinemia with a novel der(8;17)(q10;q10). | Wong KF et al |
Citation
Jean-Loup Huret
der(8;17)(q10;q10)
Atlas Genet Cytogenet Oncol Haematol. 2018-08-01
Online version: http://atlasgeneticsoncology.org/haematological/1801/gene-explorer/new-content/cancer-prone-explorer/submit-meetings/
