B-cell lymphomas: The band 10q24 is involved in 7% of low-grade B-cell lymphomas, splenic marginal zone B-cell lymphomas in particular (Solé et al., 2001; Lefebvre et al., 2007, Nadal, unpublished observation) and also, but less frequently, in intermediate and high risk lymphomas (Neri et al., 1991).
Other chronic lympho proliferative diseases: Multiple myeloma (Migliazza et al., 1994; Mohamed et al.), chronic lymphocytic leukemia (CLL) (Migliazza, 1994)

Unknown.

The t(10;14)(q24;q32) is a rare but recurrent abnormality in lymphoid malignancies.

The following known recurrent abnormalities were found in one case each: +3, +7, and +12.

t(10;14)(q24;q32) translocation juxtaposes IGH constant region gene with NFKB2 gene (Neri et al., 1991). The fusion gene NFKB2/IGH results in the constitutional activation of the non-canonical NFKB pathway. The reciprocal fusion gene IGH/NFKB2 is not transcribed.

NFKB2 gene encodes for the protein P52 which contains a DNA binding domain and an Ankyrin domain. The Ankyrin domain is thought to retain p100/P52 in the cytoplasm and thus prevent the DNA binding.
The band in 10q24 can be involved in different types of rearrangement such as cryptic deletion or translocation t(10;14). The common consequence is a truncated protein which retains the DNA binding domain but lack the Ankyrin domain (Migliazza et al., 1994). These rearrangements result in a constitutive activation of P52 which lead to the activation of the non-canonical NFKB pathway and thus promote B-cell malignancies (de silva, 2017; Guo, 2017).

Nucleus.

NFKB2/IGH

The t(10;14)(q24.31;q11) in T-ALL involves the gene TLX1 at the band 10q24.31 and not NFKB2 at band 10q24.32 (Neri et al., 1991).