t(3;13)(q27;q14) LCP1/BCL6
1998-01-01 Jean-Loup Huret , Jean-Luc Lai Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
NHL
Phenotype stem cell origin
found in various types of NHL (e.g. Burkitts lymphoma andfollicular lymphoma); the translocation is therefore likely to be a secondary event in the course of the disease.
Epidemiology
only 3 cases available to date; all three are adult female patients
Cytogenetics
Cytogenetics morphological
found twice (out of three occurrence) as asecondary anomaly: following the well known t(8;14)(q24;q32) and t(14;18)(q32;q21)
Additional anomalies
del(6q) found in 2 of 3 cases; the karyotype may be complex
Genes Involved and Proteins
Gene name
BCL6 (B-Cell Lymphoma 6)
Location
3q27.3
Gene name
LCP1 (lymphocyte cytosolic protein1)
Location
13q14.13
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9614913 | 1998 | Translocation (3;13)(q27;q14): a nonrandom and probably secondary structural change in non-Hodgkin lymphomas. | Laï JL et al |
Summary
Fusion gene
LCP1/BCL6
t(3,13)(q27; q14-21), t(14;18;(q32;q21) G - banding - Courtesy Jean-Luc Lai
Citation
Jean-Loup Huret ; Jean-Luc Lai
t(3;13)(q27;q14) LCP1/BCL6
Atlas Genet Cytogenet Oncol Haematol. 1998-01-01
Online version: http://atlasgeneticsoncology.org/haematological/2053/t
