t(3;3)(q27;q28) EIF4A2/BCL6

2009-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Non Hodgkin lymphoma.

Epidemiology

One case of follicular lymphoma transformed to diffuse aggressive lymphoma, from a study with no individual data (Akasaka et al., 2003).

Genes Involved and Proteins

Gene name
EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)
Location
3q27.3
Protein description
RNA helicase ATP-dependent; subunit of the eIF4F complex involved in translation control.
Gene name
BCL6 (B-Cell Lymphoma 6)
Location
3q27.3
Protein description
706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT ) to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003).

Bibliography

Pubmed IDLast YearTitleAuthors
127386802003BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.Akasaka T et al
125550642003Ambivalent role of BCL6 in cell survival and transformation.Albagli-Curiel O et al

Summary

Fusion gene

EIF4A2/BCL6 EIF4A2 (3q27.3) BCL6 (3q27.3) M inv(3)(q27q27) t(3;3)(q27;q27)

Citation

Jean-Loup Huret

t(3;3)(q27;q28) EIF4A2/BCL6

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/haematological/2090/t(3;3)(q27;q28)

External Links