Clinics and Pathology
Disease
Alveolar rhabdomyosarcoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37345159 | 2023 | Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma. | 214 |
| 23432728 | 2013 | A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma. | 196 |
| 30373318 | 2018 | Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma. | 175 |
| 26209235 | 2016 | Uncovering metabolism in rhabdomyosarcoma. | 145 |
| 35857643 | 2022 | Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. | 110 |
| 37968277 | 2023 | PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors. | 104 |
| 39107280 | 2024 | HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks. | 98 |
| 33182556 | 2020 | FAK Signaling in Rhabdomyosarcoma. | 97 |
| 34836971 | 2021 | BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. | 93 |
| 35879366 | 2022 | Therapeutic targeting of ATR in alveolar rhabdomyosarcoma. | 86 |
| 34639012 | 2021 | MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells. | 85 |
| 28615069 | 2017 | Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements. | 85 |
| 37639593 | 2023 | Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma. | 83 |
| 38992040 | 2024 | The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis. | 82 |
| 33490904 | 2021 | 17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma. | 81 |
| 33627785 | 2021 | FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. | 80 |
| 34720529 | 2021 | Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. | 80 |
| 29367756 | 2018 | PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. | 78 |
| 24334454 | 2014 | Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. | 73 |
| 27760049 | 2016 | Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma. | 73 |
| 33117671 | 2020 | Effects of the Oncoprotein PAX3-FOXO1 on Modulation of Exosomes Function and Protein Content: Implications on Oxidative Stress Protection and Enhanced Plasticity. | 70 |
| 38474036 | 2024 | Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response. | 68 |
| 34573355 | 2021 | High Frequency of Tumor Propagating Cells in Fusion-Positive Rhabdomyosarcoma. | 61 |
| 38402212 | 2024 | KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma. | 60 |
| 28446439 | 2017 | PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability. | 60 |
| 25030697 | 2014 | Lineage of origin in rhabdomyosarcoma informs pharmacological response. | 60 |
| 36395771 | 2022 | PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets. | 59 |
| 18457914 | 2008 | PAX3-FOXO1 fusion gene in rhabdomyosarcoma. | 59 |
| 39812007 | 2025 | DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered mouse models. | 58 |
| 26071485 | 2015 | Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. | 57 |
| 29869612 | 2018 | PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis. | 56 |
| 31824851 | 2019 | A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas. | 55 |
| 17986608 | 2007 | PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1. | 54 |
| 31578374 | 2019 | The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486. | 54 |
| 27454080 | 2016 | Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion. | 54 |
| 33182548 | 2020 | Synthetic MIR143-3p Suppresses Cell Growth in Rhabdomyosarcoma Cells by Interrupting RAS Pathways Including PAX3-FOXO1. | 54 |
| 25806826 | 2015 | The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-β pathway. | 53 |
| 32697014 | 2020 | KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma. | 53 |
| 38102136 | 2023 | PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. | 52 |
| 37732905 | 2023 | Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity. | 52 |
| 34187933 | 2021 | Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma. | 51 |
| 28058850 | 2017 | Molecular diagnostics in the management of rhabdomyosarcoma. | 51 |
| 33338875 | 2021 | Mutant myogenin promoter-controlled oncolytic adenovirus selectively kills PAX3-FOXO1-positive rhabdomyosarcoma cells. | 51 |
| 33589519 | 2021 | A Fusion Transcription Factor-Driven Cancer Progresses to a Fusion-Independent Relapse via Constitutive Activation of a Downstream Transcriptional Target. | 51 |
| 25659124 | 2015 | Modeling of the human alveolar rhabdomyosarcoma Pax3-Foxo1 chromosome translocation in mouse myoblasts using CRISPR-Cas9 nuclease. | 50 |
| 36097178 | 2022 | Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma. | 50 |
| 19904978 | 2009 | Phosphorylation of serine 205 by the protein kinase CK2 persists on Pax3-FOXO1, but not Pax3, throughout early myogenic differentiation. | 50 |
| 35604932 | 2022 | Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs. | 49 |
| 30190424 | 2018 | Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma. | 48 |
| 25821947 | 2015 | Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options. | 47 |
| 33509264 | 2021 | ACTA1 is inhibited by PAX3-FOXO1 through RhoA-MKL1-SRF signaling pathway and impairs cell proliferation, migration and tumor growth in Alveolar Rhabdomyosarcoma. | 44 |
| 39448867 | 2025 | Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma. | 44 |
| 24107448 | 2013 | Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcoma. | 44 |
| 28883017 | 2017 | NFκB signaling in alveolar rhabdomyosarcoma. | 43 |
| 23733015 | 2013 | Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma. | 40 |
| 23814486 | 2013 | PAX3-FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis. | 39 |
| 25985210 | 2015 | The oncogenic role of the cochaperone Sgt1. | 39 |
| 30593263 | 2019 | PAX3-FOXO1 escapes miR-495 regulation during muscle differentiation. | 38 |
| 34552155 | 2021 | Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma. | 38 |
| 29861864 | 2018 | PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. | 35 |
| 37627061 | 2023 | Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma. | 35 |
| 28138962 | 2017 | PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma. | 33 |
| 30459282 | 2018 | The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma. | 33 |
| 32416589 | 2020 | Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. | 33 |
| 32100935 | 2020 | Pediatric rhabdomyosarcoma with bone marrow metastasis. | 32 |
| 22089931 | 2012 | PAX3/7-FOXO1 fusion status in older rhabdomyosarcoma patient population by fluorescent in situ hybridization. | 28 |
| 21440083 | 2011 | Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation. | 28 |
| 37146302 | 2022 | Rhabdomyosarcomas are oncogene addicted to the activation of AVIL. | 27 |
| 33299109 | 2021 | Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies. | 25 |
| 39147820 | 2024 | Entinostat as a combinatorial therapeutic for rhabdomyosarcoma. | 24 |
| 23469153 | 2013 | Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells. | 23 |
| 25883905 | 2015 | The case for primary salivary rhabdomyosarcoma. | 16 |
| 38581035 | 2024 | TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma. | 12 |
| 26355893 | 2016 | Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma. | 11 |
| 29146205 | 2018 | PAX3-FOXO1: Zooming in on an "undruggable" target. | 0 |
| 26008753 | 2015 | Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis. | 0 |
| 38477090 | 2023 | Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion. | 0 |
| 27453350 | 2016 | P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma. | 0 |
| 38996706 | 2024 | Anlotinib destabilizes PAX3-FOXO1 to induce rhabdomyosarcoma cell death via upregulating NEK2. | 0 |
| 39868247 | 2025 | PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma. | 0 |
| 21882254 | 2012 | PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma. | 0 |
| 35465663 | 2022 | Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid Dentitheca habereri. | 0 |
| 34980443 | 2022 | [Alveolar rhabdomyosarcoma: Two fusion-negative cases lacking PAX3-FOXO1 and PAX7-FOXO1]. | 0 |
| 25398439 | 2015 | PLK1 phosphorylates PAX3-FOXO1, the inhibition of which triggers regression of alveolar Rhabdomyosarcoma. | 0 |
| 38885148 | 2024 | Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future. | 0 |
| 22037868 | 2011 | PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis. | 0 |
| 32800827 | 2021 | Gene Fusions in Ocular Adnexal Tumors. | 0 |
| 31989508 | 2020 | Signaling pathways in Rhabdomyosarcoma invasion and metastasis. | 0 |
| 23645752 | 2013 | Regulation of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma. | 0 |
| 31888889 | 2020 | Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death. | 0 |
| 27261335 | 2016 | RGD liposome-protamine-siRNA (LPR) nanoparticles targeting PAX3-FOXO1 for alveolar rhabdomyosarcoma therapy. | 0 |
| 22454413 | 2012 | PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification. | 0 |
| 39071299 | 2024 | Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo. | 0 |
| 36722003 | 2023 | PAX-FOXO1 fusion status in children and adolescents with alveolar rhabdomyosarcoma: Impact on clinical, pathological, and survival features. | 0 |
| 38526790 | 2024 | CRISPR-Cas9-Mediated Bioluminescent Tagging of Endogenous Proteins by Fluorescent Protein-Assisted Cell Sorting. | 0 |
| 18414034 | 2008 | Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor. | 0 |
| 36044855 | 2022 | The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth. | 0 |
| 39211084 | 2024 | PAX fusion proteins deregulate gene networks controlling mitochondrial translation in pediatric rhabdomyosarcoma. | 0 |
| 29277758 | 2018 | Sphingosine Induces Apoptosis and Down-regulation of MYCN in PAX3-FOXO1-positive Alveolar Rhabdomyosarcoma Cells Irrespective of TP53 Mutation. | 0 |
| 34218227 | 2022 | A Review of Effusion Cytomorphology of Small Round Cell Tumors. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 21254373 | 2011 | Prognostic value of PAX-FKHR fusion status in alveolar rhabdomyosarcoma: a report from the cooperative soft tissue sarcoma study group (CWS). | Stegmaier S et al |
Summary
Fusion gene
PAX3/FOXO1 PAX3 (2q36.1) FOXO1 (13q14.11)
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
Citation
Philippe Dessen ; Jean-Loup Huret
t(2;13)(q36;q14) PAX3/FOXO1
Atlas Genet Cytogenet Oncol Haematol. 2018-01-01
Online version: http://atlasgeneticsoncology.org/haematological/3393
