1.Department of Pathology, The Johns Hopkins Hospital, Baltimore MD (PA) pargani@jhmi.edu
Review on Renal cell carcinomas with MiT family translocations, with data on clinics, and the genes involved.
Neoplasm
Fusion
Age Range (years)
Translocation
ASPS
ASPSCR1/TFE3
1-71
der(17)(X;17)(p11.2q25)
RCC
1-75
t(X;17)(p11.2;q25)
PRCC/TFE3
2-69
t(X;1)(p11.2;q21)
SFPQ/TFE3
3-68
t(X;1)(p11.2;p34)
NONO/TFE3
29-51
inv(X)(p11.2q12)
CLTC/TFE3
14
t(X;17)(p11.2;q23)
PARP14/TFE3
32
t(X;3)(p11.2;q23)
DVL2/TFE3
73
t(X;17)(p11;p13)
LUC7L3/TFE3
t(X;17)(p11;q21)
RBM10/TFE3
inv(X)(p11.2p11.23)
KHSRP/TFE3
t(X;19)(p11.2;p13)
Xp11 PEComa
SFPQ/TFE3, NONO/TFE3 and others
9-55
t(X;1)(p11.2;p34), inv(X)(p11.2q12) and others
Melanotic Xp11 Translocation Cancer
SFPQ/TFE3 and likely others
11-55
t(X;1)(p11.2;q34) and likely others
Subset of Epithelioid Hemangioendothelioma
YAP1/TFE3
14-50
t(X;11)(p11.2;q13)
MALAT1(Alpha)-TFEB
t(6;11)(p21;q12)
CLTC/TFEB
t(6;17)(p21;q23)
KHDRBS2/TFEB
inv(6)(p21q11)
COL21/TFEB
inv(6)(p21p12)
TFEB/CADM2
t(3;6)(p12;p21)
Pedram Argani
Kidney: Renal cell carcinomas with MiT family translocation
Atlas Genet Cytogenet Oncol Haematol. 2016-08-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/5118/kidney-renal-cell-carcinomas-with-mit-family-translocation