1.Dip. Scienze e Tecnologie Biomediche, Sezione di Biologia e Genetica, Università di Cagliari, Cittadella Universitaria, 09142 Monserrato (CA), Italy
Three different diagnostic systems are used: - CIN (Cervical Intraepithelial Neoplasia, CIN I, CIN II, CIN III),- SIL (Low grade SIL -LSIL - High grade SIL - HSIL), Epithelial neoplasia:
, Mixed epithelial and mesenchymal neoplasia: ,
, Secondary tumours are uterine corpus tumours originating outside the uterus.
UTERINE CERVIX. A pronounced chromosomal instability in advanced cervical carcinomas has been observed by comparative genomic hybridization (CGH.). CGH profiles show 2q33-q37 deletions and 3q gains as characteristic changes. FISH analysis on squamous cell carcinoma showed an increased DNA copy number in chromosomes 3 and X in the development and progression from HSIL to cervical carcinoma.UTERINE CORPUS. CGH data on endometrial cancer confirm G-banding results, pinpointing a central role of 8q gains in the pathogenesis of carcinosarcomas and endometrial adenocarcinomas. CGH observation shows that atypical endometrial hyperplasia shares genomic abnormalities with endometrioid carcinoma, whereas simple endometrial hyperplasia shows no genomic imbalances.
Roberta Vanni ; Giuseppina Parodo
Uterus Tumours: an Overview
Atlas Genet Cytogenet Oncol Haematol. 2004-11-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/5157/uterus-tumours-an-overview