ABL2 (Abelson homolog 2)

2000-02-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
1q25.2
IMAGE
Atlas Image
LEGEND
ABL2 (1q25) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
ABLL,ARG
FUSION GENES

DNA/RNA

Transcription

alternate splicing in 5 prime; 3.8 kb mRNA; ORF: 3548 bp

Proteins

Description

1182 amino acids; 128 kDa; comprises SH3 and SH2 domains, a protein tyrosine kinase domain, a nuclear localization domain

Function

cytoplasmic tyrosine kinase

Homology

SRC homology; closely related to ABL1

Implicated in

Entity name
Disease
acute non lymphocytic leukemia
Fusion protein
the fusion protein is composed of the HLH oligomerization domain of ETV6 and the SH2, SH3, and protein tyrosine kinase domains of ABL2

Bibliography

Pubmed IDLast YearTitleAuthors
105900831999The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts.Cazzaniga G et al
37872601986A novel human gene closely related to the abl proto-oncogene.Kruh GD et al
21985711990The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.Kruh GD et al
25677011989Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross.Seldin MF et al

Other Information

Locus ID:

NCBI: 27
MIM: 164690
HGNC: 77
Ensembl: ENSG00000143322

Variants:

dbSNP: 27
ClinVar: 27
TCGA: ENSG00000143322
COSMIC: ABL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143322ENST00000344730P42684
ENSG00000143322ENST00000367623P42684
ENSG00000143322ENST00000392043P42684
ENSG00000143322ENST00000502732P42684
ENSG00000143322ENST00000504405P42684
ENSG00000143322ENST00000507173P42684
ENSG00000143322ENST00000511413P42684
ENSG00000143322ENST00000512653P42684

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
ErbB signaling pathwayKEGGhsa04012
Viral myocarditisKEGGhsa05416
Ras signaling pathwayKEGGhsa04014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212577112011An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.114
123742882002The Abl family kinases: mechanisms of regulation and signaling.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
235526932013β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.62
186605022008ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.54
227773522013Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.45
127774002003Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.41
218922072012c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.40
244646512014miR-20a promotes prostate cancer invasion and migration through targeting ABL2.32
129501612003Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.25

Citation

Jean-Loup Huret

ABL2 (Abelson homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2000-02-01

Online version: http://atlasgeneticsoncology.org/gene/226/abl2