ABL2 (Abelson homolog 2)
2000-02-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
1q25.2
IMAGE
LEGEND
ABL2 (1q25) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
ABLL,ARG
FUSION GENES
DNA/RNA
Transcription
alternate splicing in 5 prime; 3.8 kb mRNA; ORF: 3548 bp
Proteins
Description
1182 amino acids; 128 kDa; comprises SH3 and SH2 domains, a protein tyrosine kinase domain, a nuclear localization domain
Function
cytoplasmic tyrosine kinase
Homology
SRC homology; closely related to ABL1
Implicated in
Entity name
Disease
acute non lymphocytic leukemia
Fusion protein
the fusion protein is composed of the HLH oligomerization domain of ETV6 and the SH2, SH3, and protein tyrosine kinase domains of ABL2
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10590083 | 1999 | The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. | Cazzaniga G et al |
| 3787260 | 1986 | A novel human gene closely related to the abl proto-oncogene. | Kruh GD et al |
| 2198571 | 1990 | The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. | Kruh GD et al |
| 2567701 | 1989 | Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross. | Seldin MF et al |
Other Information
Locus ID:
NCBI: 27
MIM: 164690
HGNC: 77
Ensembl: ENSG00000143322
Variants:
dbSNP: 27
ClinVar: 27
TCGA: ENSG00000143322
COSMIC: ABL2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37479901 | 2024 | Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation. | 0 |
| 37479901 | 2024 | Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation. | 0 |
| 36689065 | 2023 | Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. | 1 |
| 36689065 | 2023 | Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. | 1 |
| 34787058 | 2022 | CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis. | 7 |
| 34787058 | 2022 | CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis. | 7 |
| 33550941 | 2021 | microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2. | 2 |
| 33722655 | 2021 | Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2. | 7 |
| 33770321 | 2021 | Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation. | 15 |
| 34144039 | 2021 | Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation. | 3 |
| 33550941 | 2021 | microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2. | 2 |
| 33722655 | 2021 | Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2. | 7 |
| 33770321 | 2021 | Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation. | 15 |
| 34144039 | 2021 | Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation. | 3 |
| 32035133 | 2020 | Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells. | 13 |
Citation
Jean-Loup Huret
ABL2 (Abelson homolog 2)
Atlas Genet Cytogenet Oncol Haematol. 2000-02-01
Online version: http://atlasgeneticsoncology.org/gene/226/abl2
