Multiple trichoepitheliomas - a novel mutation in the CYLD gene. |
Amaro C, Freitas I, Lamarao P, Afonso A, Skrzypczak M, Heinritz W. |
J Eur Acad Dermatol Venereol. 2009 Nov 19. [Epub ahead of print] |
PMID 19929939 |
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Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation. |
An J, Mo D, Liu H, Veena MS, Srivatsan ES, Massoumi R, Rettig MB. |
Cancer Cell. 2008 Nov 4;14(5):394-407. |
PMID 18977328 |
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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. |
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, Dave S, Hurt EM, Tan B, Zhao H, Stephens O, Santra M, Williams DR, Dang L, Barlogie B, Shaughnessy JD Jr, Kuehl WM, Staudt LM. |
Cancer Cell. 2007 Aug;12(2):115-30. |
PMID 17692804 |
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Identification of the familial cylindromatosis tumour-suppressor gene. |
Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, Beemer FA, van Den Ouweland A, Halley D, Delpech B, Cleveland MG, Leigh I, Leisti J, Rasmussen S. |
Nat Genet. 2000 Jun;25(2):160-5. |
PMID 10835629 |
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Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. |
Blake PW, Toro JR. |
Hum Mutat. 2009 Jul;30(7):1025-36. (REVIEW) |
PMID 19462465 |
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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. |
Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. |
Nature. 2003 Aug 14;424(6950):797-801. |
PMID 12917690 |
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Tumor suppressor CYLD: negative regulation of NF-kappaB signaling and more. |
Courtois G. |
Cell Mol Life Sci. 2008 Apr;65(7-8):1123-32. (REVIEW) |
PMID 18193168 |
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The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. |
Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cardenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT. |
EMBO Rep. 2008 Sep;9(9):930-6. Epub 2008 Jul 18. |
PMID 18636086 |
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The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration. |
Gao J, Huo L, Sun X, Liu M, Li D, Dong JT, Zhou J. |
J Biol Chem. 2008 Apr 4;283(14):8802-9. Epub 2008 Jan 24. |
PMID 18222923 |
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Reduced expression of CYLD in human colon and hepatocellular carcinomas. |
Hellerbrand C, Bumes E, Bataille F, Dietmaier W, Massoumi R, Bosserhoff AK. |
Carcinogenesis. 2007 Jan;28(1):21-7. Epub 2006 Jun 13. |
PMID 16774947 |
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Conventional and array-based comparative genomic hybridization analyses of novel cell lines harboring HPV18 from glassy cell carcinoma of the uterine cervix. |
Hirai Y, Kawamata Y, Takeshima N, Furuta R, Kitagawa T, Kawaguchi T, Hasumi K, Sugai S, Noda T. |
Int J Oncol. 2004 Apr;24(4):977-86. |
PMID 15010838 |
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Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. |
Hovelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Worns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Bruning JC, Galle PR, Wallach D, Fassler R, Waisman A. |
J Exp Med. 2007 Oct 29;204(11):2615-27. Epub 2007 Oct 8. |
PMID 17923499 |
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Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma. |
Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, Gonzalez D, Chiecchio L, Dachs Cabanas E, Dagrada GP, Nightingale M, Protheroe RK, Stockley D, Else M, Dickens NJ, Cross NC, Davies FE, Morgan GJ. |
Blood. 2007 Nov 1;110(9):3291-300. Epub 2007 Jul 3. |
PMID 17609426 |
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Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. |
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC. |
J Clin Invest. 2008 May;118(5):1858-66. |
PMID 18382763 |
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Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. |
Jin W, Reiley WR, Lee AJ, Wright A, Wu X, Zhang M, Sun SC. |
J Biol Chem. 2007 May 25;282(21):15884-93. Epub 2007 Mar 27. |
PMID 17392286 |
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Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors. |
Kazakov DV, Schaller J, Vanecek T, Kacerovska D, Michal M. |
J Cutan Pathol. 2010 Feb 4. [Epub ahead of print] |
PMID 20132422 |
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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. |
Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, Van Wier S, Tiedemann R, Shi CX, Sebag M, Braggio E, Henry T, Zhu YX, Fogle H, Price-Troska T, Ahmann G, Mancini C, Brents LA, Kumar S, Greipp P, Dispenzieri A, Bryant B, Mulligan G, Bruhn L, Barrett M, Valdez R, Trent J, Stewart AK, Carpten J, Bergsagel PL. |
Cancer Cell. 2007 Aug;12(2):131-44. |
PMID 17692805 |
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Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. |
Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, Majid S, Igawa M, Dahiya R. |
Int J Cancer. 2008 Aug 1;123(3):552-60. |
PMID 18431742 |
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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. |
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G. |
Nature. 2003 Aug 14;424(6950):801-5. |
PMID 12917691 |
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CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. |
Lim JH, Ha UH, Woo CH, Xu H, Li JD. |
Cell Microbiol. 2008 Nov;10(11):2247-56. Epub 2008 Jul 16. |
PMID 18643924 |
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Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. |
Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD. |
PLoS One. 2007 Oct 10;2(10):e1032. |
PMID 17925880 |
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Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. |
Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, Spruss T, Pfeifer A, Fassler R, Bosserhoff AK. |
J Exp Med. 2009 Jan 16;206(1):221-32. Epub 2009 Jan 5. |
PMID 19124656 |
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Five novel germline function-impairing mutations of CYLD in Italian patients with multiple cylindromas. |
Nasti S, Pastorino L, Bruno W, Gargiulo S, Battistuzzi L, Zavattaro E, Leigheb G, De Francesco V, Tulli A, Mari F, Scarra GB, Ghiorzo P. |
Clin Genet. 2009 Nov;76(5):481-5. Epub 2009 Oct 6. |
PMID 19807742 |
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Negative regulation of JNK signaling by the tumor suppressor CYLD. |
Reiley W, Zhang M, Sun SC. |
J Biol Chem. 2004 Dec 31;279(53):55161-7. Epub 2004 Oct 20. |
PMID 15496400 |
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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. |
Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC. |
J Exp Med. 2007 Jun 11;204(6):1475-85. Epub 2007 Jun 4. |
PMID 17548520 |
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Regulation of T cell development by the deubiquitinating enzyme CYLD. |
Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, Sun SC. |
Nat Immunol. 2006 Apr;7(4):411-7. Epub 2006 Feb 26. |
PMID 16501569 |
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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. |
Reyes-Turcu FE, Ventii KH, Wilkinson KD. |
Annu Rev Biochem. 2009;78:363-97. (REVIEW) |
PMID 19489724 |
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The tumor suppressor CYLD regulates entry into mitosis. |
Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJ. |
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8869-74. Epub 2007 May 10. |
PMID 17495026 |
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Capturing protein tails by CAP-Gly domains. |
Steinmetz MO, Akhmanova A. |
Trends Biochem Sci. 2008 Nov;33(11):535-45. Epub 2008 Oct 4. (REVIEW) |
PMID 18835717 |
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TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. |
Stokes A, Wakano C, Koblan-Huberson M, Adra CN, Fleig A, Turner H. |
Cell Signal. 2006 Oct;18(10):1584-94. Epub 2006 Feb 23. |
PMID 16500080 |
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Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm. |
Strobel P, Zettl A, Ren Z, Starostik P, Riedmiller H, Storkel S, Muller-Hermelink HK, Marx A. |
Am J Surg Pathol. 2002 Jan;26(1):119-24. |
PMID 11756779 |
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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. |
Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G. |
Nature. 2003 Aug 14;424(6950):793-6. |
PMID 12917689 |
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A novel missense mutation of CYLD gene in a Chinese family with multiple familial trichoepithelioma. |
Wang FX, Yang LJ, Li M, Zhang SL, Zhu XH. |
Arch Dermatol Res. 2010 Jan;302(1):67-70. Epub 2009 Nov 13. |
PMID 19911186 |
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CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. |
Wickstrom SA, Masoumi KC, Khochbin S, Fassler R, Massoumi R. |
EMBO J. 2010 Jan 6;29(1):131-44. Epub 2009 Nov 5. |
PMID 19893491 |
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Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. |
Wooten MW, Geetha T, Babu JR, Seibenhener ML, Peng J, Cox N, Diaz-Meco MT, Moscat J. |
J Biol Chem. 2008 Mar 14;283(11):6783-9. Epub 2008 Jan 3. |
PMID 18174161 |
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Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. |
Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC. |
Dev Cell. 2007 Nov;13(5):705-16. |
PMID 17981138 |
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Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. |
Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC. |
J Biol Chem. 2008 Jul 4;283(27):18621-6. Epub 2008 May 8. |
PMID 18467330 |
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Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. |
Zhong S, Fields CR, Su N, Pan YX, Robertson KD. |
Oncogene. 2007 Apr 19;26(18):2621-34. Epub 2006 Oct 9. |
PMID 17043644 |
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