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DAPK1 (death-associated protein kinase 1)

Written2009-02Regine Schneider-Stock, Albert Roessner, Khouloud Bajbouj
Department of Pathology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany

(Note : for Links provided by Atlas : click)

Identity

Alias_namesdeath-associated protein kinase 1
Alias_symbol (synonym)DAPK
HGNC (Hugo) DAPK1
LocusID (NCBI) 1612
Atlas_Id 417
Location 9q21.33  [Link to chromosome band 9q21]
Location_base_pair Starts at 90113450 and ends at 90323549 bp from pter ( according to hg19-Feb_2009)  [Mapping DAPK1.png]
Fusion genes
(updated 2016)
DAPK1 (9q21.33) / AGTPBP1 (9q21.33)DAPK1 (9q21.33) / DAPK1 (9q21.33)DAPK1 (9q21.33) / GRIA3 (Xq25)
DAPK1 (9q21.33) / MAMDC2 (9q21.12)DAPK1 (9q21.33) / NRBP1 (2p23.3)DAPK1 (9q21.33) / RBM5 (3p21.31)
TGDS (13q32.1) / DAPK1 (9q21.33)

DNA/RNA

Description 160kDa, 1430 amino acids.
DAPKβ has an additional unique carboxyl-terminal 12- amino acid extension.
Transcription 2 alternative transcripts.

Protein

 
  Schematic diagram of DAP-kinase protein structure. The 160 kDa actin microfilament-associated Ca2+/calmodulin (CaM)-regulated Serine/Threonine kinase bears a multiple domain structure. The catalytic and the calmodulin regulatory domains determine substrate specificity and regulation of kinase catalytic activity, respectively. The non-catalytic association domains, involved in subcellular localization or interactions with other proteins, include the 8 ankyrin repeats, two nucleotide-binding P-loops, a cytoskeleton-binding region, and a death domain. Phosphorylation by RSK at Ser289 triggers a suppression of DAPK proapoptotic function (Anjum et al., 2005). The autophosphorylation site was mapped to Ser308 within the CaM-regulatory domain (Shohat et al., 2002). ERK phosphorylates DAPK at Ser735, which stimulates DAPK-mediated apoptosis (Chen et al., 2005).
Description LAR and Src have been identified as a DAPK regulator through their reciprocal modification of DAPK Y491/492 residues.
Function Apoptosis
DAPK-mediated cell death is characterized by two main characteristics: formation of autophagic vesicles and membrane blebbing (Shohat et al., 2002).

Migration
DAPK is involved in stabilization of stress fibers through phosphorylation of MLC which occurs prior the onset of apoptosis (Kuo et al., 2003).

Signal transduction
DAP kinase is up-regulated by hyperproliferative signals, and operates upstream of p19-ARF and p53 to induce apoptosis. Whereas the inactivation or loss of DAP kinase significantly reduces the p53 responses to c-Myc or E2F-1, it does not completely eliminate them, indicating that DAP kinase is not an exclusive player upstream of p19ARF/p53 (Raveh et al., 2001). Recent studies showed several mechanisms influencing DAPK activity. These include RSK dependent inactivation of DAPK1 (Anjum et al., 2005) and ERK-dependent activation of the proapoptotic function of DAPK (Chen et al., 2005). Death-promoting effects of DAPK are counteracted by Bcl2 (Cohen et al., 1997).
It was shown that the apoptosis regulatory activities mediated by DAPK are controlled both by phosphorylation status and protein stability.

Phosphorylation sites
There are three well characterized phosphorylation sites on DAPK protein;
1) the phosphorylation by RSK at Ser289, which triggers a suppression of DAPK pro-apoptotic function (Anjum et al., 2005),
2) the autophosphorylation site, which was mapped to Ser308 within the CaM-regulatory domain (Shohat et al., 2002), and
3) ERK-phosphorylation of DAPK at Ser735, which stimulates DAPK-mediated apoptosis by switching off the ERK-C/EBP-beta pathway (Chen et al., 2005). Src phosphorylates DAPK at Y491/492, which induces DAPK intra-/intermolecular interaction and inactivation (Wang et al., 2007).

Interaction partners
Cathepsin B can directly interact with DAPK, forming a stable immune complex (Lin et al., 2007). It has been found that inhibition of HSP90 results in degradation of active dephosphorylated DAPK via the ubiquitin proteasome pathway. DAPK can also form heterocomplexes composed of HSP90 and CHIP or DIP1/Mib1, indicating that the heightened surveillance and modulation of DAPK activities is critical to accurate regulation of apoptosis and cellular homeostasis (Zhang et al., 2007). An interaction between UNC5C (UNC5H3) and DAPK1 was demonstrated (Llambi et al., 2005), whereby this interaction was shown to be dependent on both UNC5H2 lipid raft localization and palmitoylation (Maisse et al., 2008). An interaction between DAPK1 promoter and transcription factors ATF2 and c-jun was demonstrated in cisplatin-treated human breast cancer cells (Hayakawa et al., 2004). Amino acid starvation of cells induced a stable immune complex between microtubule-associated protein MAP1B and DAPK-1 (Harrison et al., 2008) highlighting a new mechanism for authophagy and membrane blebbing. There was found an interaction between DAPK and TSC2 proteins in response to growth factor stimulation that links the DAPK and mTORC1 signaling pathways affecting cell survival, autophagy, and apoptosis (Stevens et al., 2009).

Known substrates
DAPK phosphorylates the myosin II regulatory light chain (Jin et al., 2001) and tropomyosin in response to ERK activation by hydrogen peroxide leading to stress fiber formation (Houle et al., 2007). Furthermore, Syntaxin is a DAP kinase substrate and provides a novel signal transduction pathway by which syntaxin function could be regulated in response to intracellular [Ca2+] and synaptic activity (Tian et al., 2003). Also one of the common DAPK substrate is p19ARF (Raveh et al., 2001). Shani el al. (2004) and Mukhopadhyay et al. (2008) showed that ZIPK serves as a substrate for DAPK. It has been reported that the mammalian 40S ribosomal protein S6 is a DAPK substrate (Schumacher et al., 2006).

Homology Member of the Death-associated protein kinase family (Shohat et al., 2002):
  • DRP-1/DAPK2 (Death-Related Protein 1)
  • DAPK3/ZIPK/DLK (Zipper Interacting Protein Kinase/DAP Like Kinase)
  • DRAK1/DRAK2 (DAPk-Related Apoptosis inducing protein Kinases 1 and 2)

  • Mutations

    Germinal A novel mutation (N1347S) in the death domain of DAPK-1 alters the oligomeric structure of the death domain, de-stabilizes DAPK-1 binding to ERK, and prevents ERK:DAPK-1-dependent apoptosis (Stevens et al., 2007).

    Implicated in

    Note
    Entity Cancers in general:
    Note DAPK is a tumor suppressor gene. Promoter hypermethylation and homozygous deletion of DAPK1 are the major alternative mechanisms of DAPK protein loss in cancers (Kawaguchi et al., 2004).
      
    Entity Lung cancer
    Note DAPK hypermethylation was not detectable in normal lung specimens but in 39% of invasive adenocarcinoma (Licchesi et al., 2008).
      
    Entity Non small cell lung cancer
    Note DAPK hypermethylation was evident in 50% of resected primary nonsmall cell lung cancers (Wang et al., 2008).
      
    Entity Gastric cancer
    Note DAPK methylation might predict the prognosis and response to chemotherapy in gastric cancer (Kato et al., 2008).
      
    Entity Barrett's adenocarcinoma
    Note DAPK inactivation by promoter hypermethylation as an early event in Barrett's carcinogenesis (Kuester et al., 2007).
      
    Entity Colon cancer
    Note DAPK inactivation by promoter hypermethylation as an early event in colorectal carcinogenesis (Mittag et al., 2006).
      
    Entity Cervical cancer
    Note DAPK hypermethylation was found more frequently in cervical squamous cell carcinoma than in cervical adenocarcinoma (Kang et al., 2006).
      
    Entity Brain disorders:
      
    Entity Ischemia
    Note DAPK1 regulates exocytosis of neurotransmitter release by phosphorylation of syntaxin-1 (Tian et al., 2003) and protecting neurons during development or recovery from hypoxic-ischemic injury (Schumacher et al., 2002).
    DAPK is inactive in normal brain tissues, where it is found in its phosphorylated state and becomes rapidly and persistently dephosphorylated and activated in response to ischemia in vivo (Shamloo et al., 2005).
      
    Entity Alzheimer's disease
    Note Two SNPs in the DAPK1 gene are associated with late-onset Alzheimer's disease (Li et al., 2006).
      

    Bibliography

    The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.
    Anjum R, Roux PP, Ballif BA, Gygi SP, Blenis J.
    Curr Biol. 2005 Oct 11;15(19):1762-7.
    PMID 16213824
     
    Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
    Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF, Chen RH.
    EMBO J. 2005 Jan 26;24(2):294-304. Epub 2004 Dec 16.
    PMID 15616583
     
    DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity.
    Cohen O, Feinstein E, Kimchi A.
    EMBO J. 1997 Mar 3;16(5):998-1008.
    PMID 9118961
     
    DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.
    Harrison B, Kraus M, Burch L, Stevens C, Craig A, Gordon-Weeks P, Hupp TR.
    J Biol Chem. 2008 Apr 11;283(15):9999-10014. Epub 2008 Jan 14.
    PMID 18195017
     
    Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress.
    Hayakawa J, Mittal S, Wang Y, Korkmaz KS, Adamson E, English C, Ohmichi M, McClelland M, Mercola D.
    Mol Cell. 2004 Nov 19;16(4):521-35.
    PMID 15546613
     
    DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress.
    Houle F, Poirier A, Dumaresq J, Huot J.
    J Cell Sci. 2007 Oct 15;120(Pt 20):3666-77. Epub 2007 Sep 25.
    PMID 17895359
     
    Identification of a new form of death-associated protein kinase that promotes cell survival.
    Jin Y, Blue EK, Dixon S, Hou L, Wysolmerski RB, Gallagher PJ.
    J Biol Chem. 2001 Oct 26;276(43):39667-78. Epub 2001 Aug 2.
    PMID 11485996
     
    Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma.
    Kang S, Kim JW, Kang GH, Lee S, Park NH, Song YS, Park SY, Kang SB, Lee HP.
    Int J Cancer. 2006 May 1;118(9):2168-71.
    PMID 16331610
     
    Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer.
    Kato K, Iida S, Uetake H, Takagi Y, Yamashita T, Inokuchi M, Yamada H, Kojima K, Sugihara K.
    Int J Cancer. 2008 Feb 1;122(3):603-8.
    PMID 17943730
     
    Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression.
    Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Tamiya S, Iwamoto Y, Tsuneyoshi M.
    Hum Pathol. 2004 Oct;35(10):1266-71.
    PMID 15492995
     
    Early involvement of death-associated protein kinase promoter hypermethylation in the carcinogenesis of Barrett's esophageal adenocarcinoma and its association with clinical progression.
    Kuester D, Dar AA, Moskaluk CC, Krueger S, Meyer F, Hartig R, Stolte M, Malfertheiner P, Lippert H, Roessner A, El-Rifai W, Schneider-Stock R.
    Neoplasia. 2007 Mar;9(3):236-45.
    PMID 17401463
     
    Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase.
    Kuo JC, Lin JR, Staddon JM, Hosoya H, Chen RH.
    J Cell Sci. 2003 Dec 1;116(Pt 23):4777-90.
    PMID 14600263
     
    DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.
    Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JS, Smemo S, Hinrichs A, Tacey K, Toombs TA, Kwok S, Catanese J, White TJ, Maxwell TJ, Hollingworth P, Abraham R, Rubinsztein DC, Brayne C, Wavrant-De Vrieze F, Hardy J, O'Donovan M, Lovestone S, Morris JC, Thal LJ, Owen M, Williams J, Goate A.
    Hum Mol Genet. 2006 Sep 1;15(17):2560-8. Epub 2006 Jul 17.
    PMID 16847012
     
    Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung.
    Licchesi JD, Westra WH, Hooker CM, Herman JG.
    Clin Cancer Res. 2008 May 1;14(9):2570-8.
    PMID 18451218
     
    Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.
    Lin Y, Stevens C, Hupp T.
    J Biol Chem. 2007 Jun 8;282(23):16792-802. Epub 2007 Feb 26.
    PMID 17324927
     
    The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.
    Llambi F, Lourenco FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P.
    EMBO J. 2005 Mar 23;24(6):1192-201. Epub 2005 Feb 24.
    PMID 15729359
     
    Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H.
    Maisse C, Rossin A, Cahuzac N, Paradisi A, Klein C, Haillot ML, Herincs Z, Mehlen P, Hueber AO.
    Exp Cell Res. 2008 Aug 15;314(14):2544-52. Epub 2008 Jun 7.
    PMID 18582460
     
    DAPK promotor methylation is an early event in colorectal carcinogenesis.
    Mittag F, Kuester D, Vieth M, Peters B, Stolte B, Roessner A, Schneider-Stock R.
    Cancer Lett. 2006 Aug 18;240(1):69-75. Epub 2005 Oct 24.
    PMID 16246486
     
    DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.
    Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL.
    Mol Cell. 2008 Nov 7;32(3):371-82.
    PMID 18995835
     
    DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
    Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A.
    Nat Cell Biol. 2001 Jan;3(1):1-7.
    PMID 11146619
     
    Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis.
    Schumacher AM, Velentza AV, Watterson DM, Dresios J.
    Biochemistry. 2006 Nov 14;45(45):13614-21.
    PMID 17087515
     
    Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia.
    Shamloo M, Soriano L, Wieloch T, Nikolich K, Urfer R, Oksenberg D.
    J Biol Chem. 2005 Dec 23;280(51):42290-9. Epub 2005 Oct 3.
    PMID 16204252
     
    Death-Associated Protein Kinase Phosphorylates ZIP Kinase, Forming a Unique Kinase Hierarchy To Activate Its Cell Death Functions.
    Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, Kimchi A.
    Mol Cell Biol. 2004 Oct;24(19):8611-26.
    PMID 15367680
     
    Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.
    Stevens C, Lin Y, Harrison B, Burch L, Ridgway RA, Sansom O, Hupp T.
    J Biol Chem. 2009 Jan 2;284(1):334-44. Epub 2008 Oct 30.
    PMID 18974095
     
    Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.
    Tian JH, Das S, Sheng ZH.
    J Biol Chem. 2003 Jul 11;278(28):26265-74. Epub 2003 May 2.
    PMID 12730201
     
    The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.
    Wang WJ, Kuo JC, Ku W, Lee YR, Lin FC, Chang YL, Lin YM, Chen CH, Huang YP, Chiang MJ, Yeh SW, Wu PR, Shen CH, Wu CT, Chen RH.
    Mol Cell. 2007 Sep 7;27(5):701-16.
    PMID 17803936
     
    Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray.
    Wang Y, Zhang D, Zheng W, Luo J, Bai Y, Lu Z.
    Cancer. 2008 Mar 15;112(6):1325-36.
    PMID 18286531
     

    Citation

    This paper should be referenced as such :
    Schneider-Stock, R ; Roessner, A ; Bajbouj, K
    DAPK1 (death-associated protein kinase 1)
    Atlas Genet Cytogenet Oncol Haematol. 2010;14(1):7-10.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/DAPK1ID417ch9q21.html


    Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
      Head and Neck: Epidermoid carcinoma


    External links

    Nomenclature
    HGNC (Hugo)DAPK1   2674
    Cards
    AtlasDAPK1ID417ch9q21
    Entrez_Gene (NCBI)DAPK1  1612  death associated protein kinase 1
    AliasesDAPK
    GeneCards (Weizmann)DAPK1
    Ensembl hg19 (Hinxton)ENSG00000196730 [Gene_View]  chr9:90113450-90323549 [Contig_View]  DAPK1 [Vega]
    Ensembl hg38 (Hinxton)ENSG00000196730 [Gene_View]  chr9:90113450-90323549 [Contig_View]  DAPK1 [Vega]
    ICGC DataPortalENSG00000196730
    TCGA cBioPortalDAPK1
    AceView (NCBI)DAPK1
    Genatlas (Paris)DAPK1
    WikiGenes1612
    SOURCE (Princeton)DAPK1
    Genetics Home Reference (NIH)DAPK1
    Genomic and cartography
    GoldenPath hg19 (UCSC)DAPK1  -     chr9:90113450-90323549 +  9q34.1   [Description]    (hg19-Feb_2009)
    GoldenPath hg38 (UCSC)DAPK1  -     9q34.1   [Description]    (hg38-Dec_2013)
    EnsemblDAPK1 - 9q34.1 [CytoView hg19]  DAPK1 - 9q34.1 [CytoView hg38]
    Mapping of homologs : NCBIDAPK1 [Mapview hg19]  DAPK1 [Mapview hg38]
    OMIM600831   
    Gene and transcription
    Genbank (Entrez)AA846231 AA854055 AB208871 AK127855 AK295119
    RefSeq transcript (Entrez)NM_001288729 NM_001288730 NM_001288731 NM_004938
    RefSeq genomic (Entrez)NC_000009 NC_018920 NG_029883 NT_008470 NW_004929366
    Consensus coding sequences : CCDS (NCBI)DAPK1
    Cluster EST : UnigeneHs.693441 [ NCBI ]
    CGAP (NCI)Hs.693441
    Alternative Splicing GalleryENSG00000196730
    Gene ExpressionDAPK1 [ NCBI-GEO ]   DAPK1 [ EBI - ARRAY_EXPRESS ]   DAPK1 [ SEEK ]   DAPK1 [ MEM ]
    Gene Expression Viewer (FireBrowse)DAPK1 [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)1612
    GTEX Portal (Tissue expression)DAPK1
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP53355   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtP53355  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProP53355
    Splice isoforms : SwissVarP53355
    PhosPhoSitePlusP53355
    Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    DEATH_DOMAIN (PS50017)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ROC (PS51424)   
    Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    COR    DAPK1    DEATH-like_dom    Death_domain    Kinase-like_dom    P-loop_NTPase    Prot_kinase_dom    Protein_kinase_ATP_BS    ROC_dom    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
    Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    COR (PF16095)    Death (PF00531)    Pkinase (PF00069)   
    Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam16095    pfam00531    pfam00069   
    Domain families : Smart (EMBL)ANK (SM00248)  DEATH (SM00005)  S_TKc (SM00220)  
    Conserved Domain (NCBI)DAPK1
    DMDM Disease mutations1612
    Blocks (Seattle)DAPK1
    PDB (SRS)1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    PDB (PDBSum)1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    PDB (IMB)1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    PDB (RSDB)1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    Structural Biology KnowledgeBase1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    SCOP (Structural Classification of Proteins)1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    CATH (Classification of proteins structures)1IG1    1JKK    1JKL    1JKS    1JKT    1P4F    1WVW    1WVX    1WVY    1YR5    2W4J    2W4K    2X0G    2XUU    2XZS    2Y0A    2Y4P    2Y4V    2YAK    3DFC    3DGK    3EH9    3EHA    3F5G    3F5U    3GU4    3GU5    3GU6    3GU7    3GU8    3GUB    3ZXT    4B4L    4PF4    4TL0    4TXC    4UV0    4YO4    4YPD    5AUT    5AUU    5AUV    5AUW    5AUX    5AUY    5AUZ    5AV0    5AV1    5AV2    5AV3    5AV4   
    SuperfamilyP53355
    Human Protein AtlasENSG00000196730
    Peptide AtlasP53355
    HPRD02902
    IPIIPI01010067   IPI00021250   IPI00745936   IPI00947196   IPI00909908   
    Protein Interaction databases
    DIP (DOE-UCLA)P53355
    IntAct (EBI)P53355
    FunCoupENSG00000196730
    BioGRIDDAPK1
    STRING (EMBL)DAPK1
    ZODIACDAPK1
    Ontologies - Pathways
    QuickGOP53355
    Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  GTP binding  cytoplasm  plasma membrane  protein phosphorylation  protein phosphorylation  apoptotic process  apoptotic process  extrinsic apoptotic signaling pathway via death domain receptors  regulation of autophagy  actin cytoskeleton  syntaxin-1 binding  negative regulation of translation  intracellular signal transduction  identical protein binding  regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  protein autophosphorylation  protein autophosphorylation  cellular response to interferon-gamma  apoptotic signaling pathway  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  regulation of N-methyl-D-aspartate selective glutamate receptor activity  
    Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  GTP binding  cytoplasm  plasma membrane  protein phosphorylation  protein phosphorylation  apoptotic process  apoptotic process  extrinsic apoptotic signaling pathway via death domain receptors  regulation of autophagy  actin cytoskeleton  syntaxin-1 binding  negative regulation of translation  intracellular signal transduction  identical protein binding  regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  protein autophosphorylation  protein autophosphorylation  cellular response to interferon-gamma  apoptotic signaling pathway  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  regulation of N-methyl-D-aspartate selective glutamate receptor activity  
    Pathways : KEGGPathways in cancer    Bladder cancer   
    REACTOMEP53355 [protein]
    REACTOME PathwaysR-HSA-418889 Ligand-independent caspase activation via DCC [pathway]
    NDEx NetworkDAPK1
    Atlas of Cancer Signalling NetworkDAPK1
    Wikipedia pathwaysDAPK1
    Orthology - Evolution
    OrthoDB1612
    GeneTree (enSembl)ENSG00000196730
    Phylogenetic Trees/Animal Genes : TreeFamDAPK1
    HOVERGENP53355
    HOGENOMP53355
    Homologs : HomoloGeneDAPK1
    Homology/Alignments : Family Browser (UCSC)DAPK1
    Gene fusions - Rearrangements
    Fusion : MitelmanDAPK1/AGTPBP1 [9q21.33/9q21.33]  
    Fusion : MitelmanTGDS/DAPK1 [13q32.1/9q21.33]  [t(9;13)(q21;q32)]  
    Fusion: TCGADAPK1 9q21.33 AGTPBP1 9q21.33 LUAD
    Fusion: TCGATGDS 13q32.1 DAPK1 9q21.33 BRCA
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerDAPK1 [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)DAPK1
    dbVarDAPK1
    ClinVarDAPK1
    1000_GenomesDAPK1 
    Exome Variant ServerDAPK1
    ExAC (Exome Aggregation Consortium)DAPK1 (select the gene name)
    Genetic variants : HAPMAP1612
    Genomic Variants (DGV)DAPK1 [DGVbeta]
    DECIPHER (Syndromes)9:90113450-90323549  ENSG00000196730
    CONAN: Copy Number AnalysisDAPK1 
    Mutations
    ICGC Data PortalDAPK1 
    TCGA Data PortalDAPK1 
    Broad Tumor PortalDAPK1
    OASIS PortalDAPK1 [ Somatic mutations - Copy number]
    Somatic Mutations in Cancer : COSMICDAPK1  [overview]  [genome browser]  [tissue]  [distribution]  
    Mutations and Diseases : HGMDDAPK1
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    BioMutasearch DAPK1
    DgiDB (Drug Gene Interaction Database)DAPK1
    DoCM (Curated mutations)DAPK1 (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)DAPK1 (select a term)
    intoGenDAPK1
    NCG5 (London)DAPK1
    Cancer3DDAPK1(select the gene name)
    Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Diseases
    OMIM600831   
    Orphanet
    MedgenDAPK1
    Genetic Testing Registry DAPK1
    NextProtP53355 [Medical]
    TSGene1612
    GENETestsDAPK1
    Huge Navigator DAPK1 [HugePedia]
    snp3D : Map Gene to Disease1612
    BioCentury BCIQDAPK1
    ClinGenDAPK1
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD1612
    Chemical/Pharm GKB GenePA27142
    Clinical trialDAPK1
    Miscellaneous
    canSAR (ICR)DAPK1 (select the gene name)
    Probes
    Litterature
    PubMed190 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineDAPK1
    EVEXDAPK1
    GoPubMedDAPK1
    iHOPDAPK1
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    indexed on : Thu Jan 12 11:23:15 CET 2017

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