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LCK (lymphocyte-specific protein tyrosine kinase)

Written2005-05Deepak Pralhad Patil, Gopal Chandra Kundu
CSIR-JRF,c/o Dr. G. C. Kundu, National Center for Cell Science, NCCS Complex, Ganeshkhind, Pune(Maharastra)-411007, India

(Note : for Links provided by Atlas : click)

Identity

Other namesP56-LCK LSK (T cell-specific protein-tyrosine kinase)
lck tyrosine kinase (AA 1-142)
membrane associated protein tyrosine kinase
proto-oncogene LCK
protein-tyrosine kinase
put. ptk (135aa); tyrosine kinase
HGNC (Hugo) LCK
LocusID (NCBI) 3932
Atlas_Id 14
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 32739712 and ends at 32751768 bp from pter ( according to hg19-Feb_2009)  [Mapping LCK.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2016)
KLC4 (6p21.1) / LCK (1p35.1)LCK (1p35.1) / LCK (1p35.1)LCK (1p35.1) / TRB ()
LCK (1p35.1) / TRBV20OR9-2 ()LCK (1p35.1) / ZNF385D (3p24.3)TRB () / LCK (1p35.1)

DNA/RNA

 
Description DNA sequence is located on chromosome no.1 on the arm 1(p).
Transcription Consists of 13 exons and 12 introns spanning 12.3 kb.
Pseudogene Unknown

Protein

 
Description The kinase p56lck (509 aa) is a T-lymphocyte-specific member of the Src family of non-receptor protein tyrosine kinase. Lck is a 56 kDa phosphoprotein expressed in variety of lymphoid and non-lymphoid cell lineages. Lck contain myristylation sequence, unique amino-terminal regions, followed by Src homology domains SH3 and SH2, a tyrosine kinase catalytic domain, and C-terminal regulatory domain. Lck associates with the inner face of the plasma membrane through its amino-terminus. This interaction is mediated by both myristic acid and palmitic acid that are bound to the amino terminal glycine and Cys-3 and/or Cys-5. The Unique region of Lck represents the domain possessing the greatest sequence diversity within this group of enzymes. This domain is thought to be involved in the interaction of the Lck with specific cellular proteins including Lck substrate. In T-cells it is known, to mediate association with the cytoplasmic tail of T-cell coreceptors CD4 and CD8a. SH3 (Src homology 3) domain is mainly implicated in the regulation of protein-protein interactions, recognizing proline-rich region found in guanine nucleotide exchange factors and GTPase activating proteins. SH2 (Src homology 2) domain of Lck recognizes phosphorylated tyrosine residues on other proteins thereby facilitating the formation of tyrosine phosphorylation-induced multimeric complexes. The tyrosine kinase domain is the catalytic domain of Lck catalyzing the transfer of the gamma-phosphate from ATP to tyrosine residues on proteins. The catalytic domain contains a site of autophosphorylation (Tyr-394), which plays an important role in regulating the protein kinase activity. A C-terminal regulatory domain is also seen containing the major site of tyrosine phosphorylation in vivo (Tyr-505). Phosphorylation of Csk (C-terminal Src kinase) at Tyr-505 leads to inactivation of Lck. Lck is also activated by oxidative stress. Reoxygenation after hypoxia induces Lck kinase activity.
Expression Expressed in variety of lymphoid and non-lymphoid cell lineages (Breast cancer tissues and other cancers too).
Localisation Cell membrane
Function
  • T-cell development,
  • T-cell activation.
  • Homology Shares sequence homology with other Src family kinases (Src, Hck, Fyn, Blk, Lyn, Fgr, Yes, and Yrk).

    Mutations

    Note Not reported yet

    Implicated in

    Note
    Entity Breast cancer, T-cell Leukemia, Colon carcinoma.
    Oncogenesis Upregulation of Lck is seen in many cases of Breast cancer. It is also overexpressed in lymphoma, colon cancer. Rearrangement of LCK gene is also reported in murine lymphoma cell line. Oncogenic activation of Lck due translocation of the LCK gene is reported in the human HSB2 T-cell leukemia with t(1;7)(p34;q34) with LCK/ TCRB involvement. Lck regulates cell motility through NF-KB mediated uPA secretion following hypoxia and reoxygenation in Breast cancer.
      
    Disease Type 1 Diabetes
    Prognosis T-cell mediated Type diabetes (Autoimmune disease) shows defect in TCR/CD3-mediated T-cell activation due to the abnormal expression of LCK.
      

    Bibliography

    Alterations in the expression of pp60c-src and p56lck associated with butyrate-induced differentiation of human colon carcinoma cells.
    Foss FM, Veillette A, Sartor O, Rosen N, Bolen JB
    Oncogene research. 1989 ; 5 (1) : 13-23.
    PMID 2476706
     
    lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter.
    Ohta M, Morita T, Shimotohno K
    Japanese journal of cancer research : Gann. 1990 ; 81 (5) : 440-444.
    PMID 2116390
     
    Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.
    Hardwick JS, Sefton BM
    Proceedings of the National Academy of Sciences of the United States of America. 1995 ; 92 (10) : 4527-4531.
    PMID 7538674
     
    Specific deficiency of p56lck expression in T lymphocytes from type 1 diabetic patients.
    Nervi S, Atlan-Gepner C, Kahn-Perles B, Lecine P, Vialettes B, Imbert J, Naquet P
    Journal of immunology (Baltimore, Md. : 1950). 2000 ; 165 (10) : 5874-5883.
    PMID 11067948
     
    Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation.
    Mahabeleshwar GH, Kundu GC
    The Journal of biological chemistry. 2003 ; 278 (52) : 52598-52612.
    PMID 14534291
     
    Tyrosine kinase, p56lck-induced cell motility, and urokinase-type plasminogen activator secretion involve activation of epidermal growth factor receptor/extracellular signal regulated kinase pathways.
    Mahabeleshwar GH, Das R, Kundu GC
    The Journal of biological chemistry. 2004 ; 279 (11) : 9733-9742.
    PMID 14699120
     
    Structure and regulation of Src family kinases.
    Boggon TJ, Eck MJ
    Oncogene. 2004 ; 23 (48) : 7918-7927.
    PMID 15489910
     
    Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
    Palacios EH, Weiss A
    Oncogene. 2004 ; 23 (48) : 7990-8000.
    PMID 15489916
     

    Citation

    This paper should be referenced as such :
    Patil, DP ; Kundu, GC
    LCK (lymphocyte-specific protein tyrosine kinase)
    Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):229-230.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/LCKID14ch1p34.html


    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
      t(1;7)(p34;q34) TRB/LCK
    t(2;5)(p23;q35) SQSTM1/ALK
    T-lineage acute lymphoblastic leukemia (T-ALL)

    External links

    Nomenclature
    HGNC (Hugo)LCK   6524
    Cards
    AtlasLCKID14ch1p34
    Entrez_Gene (NCBI)LCK  3932  LCK proto-oncogene, Src family tyrosine kinase
    AliasesIMD22; LSK; YT16; p56lck; 
    pp58lck
    GeneCards (Weizmann)LCK
    Ensembl hg19 (Hinxton)ENSG00000182866 [Gene_View]  chr1:32739712-32751768 [Contig_View]  LCK [Vega]
    Ensembl hg38 (Hinxton)ENSG00000182866 [Gene_View]  chr1:32739712-32751768 [Contig_View]  LCK [Vega]
    ICGC DataPortalENSG00000182866
    TCGA cBioPortalLCK
    AceView (NCBI)LCK
    Genatlas (Paris)LCK
    WikiGenes3932
    SOURCE (Princeton)LCK
    Genomic and cartography
    GoldenPath hg19 (UCSC)LCK  -     chr1:32739712-32751768 +  1p34.3   [Description]    (hg19-Feb_2009)
    GoldenPath hg38 (UCSC)LCK  -     1p34.3   [Description]    (hg38-Dec_2013)
    EnsemblLCK - 1p34.3 [CytoView hg19]  LCK - 1p34.3 [CytoView hg38]
    Mapping of homologs : NCBILCK [Mapview hg19]  LCK [Mapview hg38]
    OMIM153390   615758   
    Gene and transcription
    Genbank (Entrez)AA747421 AF228313 AJ865079 AK098027 AK303073
    RefSeq transcript (Entrez)NM_001042771 NM_005356
    RefSeq genomic (Entrez)NC_000001 NC_018912 NG_023387 NT_032977 NW_004929290
    Consensus coding sequences : CCDS (NCBI)LCK
    Cluster EST : UnigeneHs.470627 [ NCBI ]
    CGAP (NCI)Hs.470627
    Alternative Splicing GalleryENSG00000182866
    Gene ExpressionLCK [ NCBI-GEO ]   LCK [ EBI - ARRAY_EXPRESS ]   LCK [ SEEK ]   LCK [ MEM ]
    Gene Expression Viewer (FireBrowse)LCK [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)3932
    GTEX Portal (Tissue expression)LCK
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP06239 (Uniprot)
    NextProtP06239  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProP06239
    Splice isoforms : SwissVarP06239 (Swissvar)
    Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
    PhosPhoSitePlusP06239
    Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
    Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
    Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
    Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
    Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
    DMDM Disease mutations3932
    Blocks (Seattle)LCK
    PDB (SRS)1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    PDB (PDBSum)1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    PDB (IMB)1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    PDB (RSDB)1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    Structural Biology KnowledgeBase1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    SCOP (Structural Classification of Proteins)1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    CATH (Classification of proteins structures)1BHF    1BHH    1CWD    1CWE    1FBZ    1H92    1IJR    1KIK    1LCJ    1LCK    1LKK    1LKL    1Q68    1Q69    1QPC    1QPD    1QPE    1QPJ    1X27    2IIM    2OF2    2OF4    2OFU    2OFV    2OG8    2PL0    2ZM1    2ZM4    2ZYB    3AC1    3AC2    3AC3    3AC4    3AC5    3AC8    3ACJ    3ACK    3AD4    3AD5    3AD6    3B2W    3BRH    3BYM    3BYO    3BYS    3BYU    3KMM    3KXZ    3LCK    3MPM    4C3F    4D8K   
    SuperfamilyP06239
    Human Protein AtlasENSG00000182866
    Peptide AtlasP06239
    HPRD01080
    IPIIPI00940423   IPI00411413   IPI00515097   IPI01014319   IPI00394952   IPI00985304   IPI00981557   IPI00984672   IPI01008943   IPI00980875   
    Protein Interaction databases
    DIP (DOE-UCLA)P06239
    IntAct (EBI)P06239
    FunCoupENSG00000182866
    BioGRIDLCK
    STRING (EMBL)LCK
    ZODIACLCK
    Ontologies - Pathways
    QuickGOP06239
    Ontology : AmiGOpericentriolar material  pericentriolar material  immunological synapse  glycoprotein binding  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  ATP binding  cytosol  plasma membrane  plasma membrane  protein phosphorylation  protein dephosphorylation  protein dephosphorylation  cellular zinc ion homeostasis  cellular zinc ion homeostasis  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  transmembrane receptor protein tyrosine kinase signaling pathway  protein C-terminus binding  regulation of phosphatidylinositol 3-kinase signaling  viral process  kinase activity  protein kinase binding  protein phosphatase binding  hemopoiesis  platelet activation  T cell differentiation  T cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  SH2 domain binding  SH2 domain binding  response to drug  response to drug  CD4 receptor binding  CD8 receptor binding  identical protein binding  phosphatidylinositol 3-kinase binding  innate immune response  membrane raft  membrane raft  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  regulation of defense response to virus by virus  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of T cell activation  leukocyte migration  ATPase binding  release of sequestered calcium ion into cytosol  regulation of lymphocyte activation  extracellular exosome  positive regulation of intrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  
    Ontology : EGO-EBIpericentriolar material  pericentriolar material  immunological synapse  glycoprotein binding  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  ATP binding  cytosol  plasma membrane  plasma membrane  protein phosphorylation  protein dephosphorylation  protein dephosphorylation  cellular zinc ion homeostasis  cellular zinc ion homeostasis  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  transmembrane receptor protein tyrosine kinase signaling pathway  protein C-terminus binding  regulation of phosphatidylinositol 3-kinase signaling  viral process  kinase activity  protein kinase binding  protein phosphatase binding  hemopoiesis  platelet activation  T cell differentiation  T cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  SH2 domain binding  SH2 domain binding  response to drug  response to drug  CD4 receptor binding  CD8 receptor binding  identical protein binding  phosphatidylinositol 3-kinase binding  innate immune response  membrane raft  membrane raft  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  regulation of defense response to virus by virus  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of T cell activation  leukocyte migration  ATPase binding  release of sequestered calcium ion into cytosol  regulation of lymphocyte activation  extracellular exosome  positive regulation of intrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  
    Pathways : BIOCARTAThe Co-Stimulatory Signal During T-cell Activation [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    IL 2 signaling pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]    IL-7 Signal Transduction [Genes]    Lck and Fyn tyrosine kinases in initiation of TCR Activation [Genes]   
    Pathways : KEGGNF-kappa B signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    HTLV-I infection    Primary immunodeficiency   
    REACTOMEP06239 [protein]
    REACTOME PathwaysR-HSA-202424 Downstream TCR signaling [pathway]
    REACTOME PathwaysR-HSA-202433 Generation of second messenger molecules [pathway]
    REACTOME PathwaysR-HSA-202430 Translocation of ZAP-70 to Immunological synapse [pathway]
    REACTOME PathwaysR-HSA-1257604 PIP3 activates AKT signaling [pathway]
    REACTOME PathwaysR-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [pathway]
    REACTOME PathwaysR-HSA-389356 CD28 co-stimulation [pathway]
    REACTOME PathwaysR-HSA-389513 CTLA4 inhibitory signaling [pathway]
    REACTOME PathwaysR-HSA-389357 CD28 dependent PI3K/Akt signaling [pathway]
    REACTOME PathwaysR-HSA-389359 CD28 dependent Vav1 pathway [pathway]
    REACTOME PathwaysR-HSA-164944 Nef and signal transduction [pathway]
    REACTOME PathwaysR-HSA-210990 PECAM1 interactions [pathway]
    REACTOME PathwaysR-HSA-1433557 Signaling by SCF-KIT [pathway]
    REACTOME PathwaysR-HSA-2424491 DAP12 signaling [pathway]
    REACTOME PathwaysR-HSA-1433559 Regulation of KIT signaling [pathway]
    REACTOME PathwaysR-HSA-114604 GPVI-mediated activation cascade [pathway]
    REACTOME PathwaysR-HSA-389948 PD-1 signaling [pathway]
    REACTOME PathwaysR-HSA-451927 Interleukin-2 signaling [pathway]
    REACTOME PathwaysR-HSA-202427 Phosphorylation of CD3 and TCR zeta chains [pathway]
    REACTOME PathwaysR-HSA-167590 Nef Mediated CD4 Down-regulation [pathway]
    NDEx Network
    Atlas of Cancer Signalling NetworkLCK
    Wikipedia pathwaysLCK
    Orthology - Evolution
    OrthoDB3932
    GeneTree (enSembl)ENSG00000182866
    Phylogenetic Trees/Animal Genes : TreeFamLCK
    Homologs : HomoloGeneLCK
    Homology/Alignments : Family Browser (UCSC)LCK
    Gene fusions - Rearrangements
    Fusion : MitelmanTRB/LCK [-/1p35.1]  [t(1;7)(p35;q34)]  
    Fusion : TICdbLCK [1p35.1]  -  TCR []
    Polymorphisms : SNP, variants
    NCBI Variation ViewerLCK [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)LCK
    dbVarLCK
    ClinVarLCK
    1000_GenomesLCK 
    Exome Variant ServerLCK
    ExAC (Exome Aggregation Consortium)LCK (select the gene name)
    Genetic variants : HAPMAP3932
    Genomic Variants (DGV)LCK [DGVbeta]
    Mutations
    ICGC Data PortalLCK 
    TCGA Data PortalLCK 
    Broad Tumor PortalLCK
    OASIS PortalLCK [ Somatic mutations - Copy number]
    Cancer Gene: CensusLCK 
    Somatic Mutations in Cancer : COSMICLCK 
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
    BioMutasearch LCK
    DgiDB (Drug Gene Interaction Database)LCK
    DoCM (Curated mutations)LCK (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)LCK (select a term)
    intoGenLCK
    Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
    Diseases
    DECIPHER (Syndromes)1:32739712-32751768  ENSG00000182866
    CONAN: Copy Number AnalysisLCK 
    Mutations and Diseases : HGMDLCK
    OMIM153390    615758   
    MedgenLCK
    Genetic Testing Registry LCK
    NextProtP06239 [Medical]
    TSGene3932
    GENETestsLCK
    Huge Navigator LCK [HugePedia]
    snp3D : Map Gene to Disease3932
    BioCentury BCIQLCK
    ClinGenLCK
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD3932
    Chemical/Pharm GKB GenePA30307
    Clinical trialLCK
    Miscellaneous
    canSAR (ICR)LCK (select the gene name)
    Probes
    Litterature
    PubMed463 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineLCK
    EVEXLCK
    GoPubMedLCK
    iHOPLCK
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    indexed on : Sat Jun 11 13:02:02 CEST 2016

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