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LCP1 (lymphocyte cytosolic protein1)

Written1998-03Sylvie Galiègue-Zouitina
U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France

(Note : for Links provided by Atlas : click)

Identity

Other aliasL-Plastine
LocusID (NCBI) 3936
Atlas_Id 95
Location 13q14.13  [Link to chromosome band 13q14]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP3D1 (19p13.3) / LCP1 (13q14.13)BCL6 (3q27.3) / LCP1 (13q14.13)GNB1 (1p36.33) / LCP1 (13q14.13)
LCP1 (13q14.13) / BCL6 (3q27.3)LCP1 (13q14.13) / LCP1 (13q14.13)LCP1 (13q14.13) / SLC43A1 (11q12.1)
LCP1 (13q14.13) / SLC4A10 (2q24.2)SH3KBP1 (Xp22.12) / LCP1 (13q14.13)

DNA/RNA

Description spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb)
Transcription 3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp

Protein

Description 570 amino acids
Expression restricted to the hematopoietic cells (leukocytes); expression induced in all tumor cells of all tissues
Localisation membrane
Homology belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin)

Implicated in

Note
  
Entity t(3;13)(q27;q14)/ NHL --> LCP1 - BCL6
Disease non Hodgkin follicular as well as Burkitt lymphomas
Cytogenetics t(3;13) is observed as a secondary anomaly
Hybrid/Mutated Gene both 5' L-Plastin- 3' BCL6 and 5' BCL6 - 3' L-Plastin, leading to two fusion transcripts
Abnormal Protein no fusion protein, but promoter exchange between both partner genes
  

Bibliography

Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant.
Laï JL, Michaux L, Dastugue N, Vasseur F, Daudignon A, Facon T, Bauters F, Zandecki M
Cancer genetics and cytogenetics. 1998 ; 104 (2) : 133-138.
PMID 9666807
 
Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.
Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J
Molecular and cellular biology. 1988 ; 8 (11) : 4659-4668.
PMID 3211125
 
Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.
Lin CS, Park T, Chen ZP, Leavitt J
The Journal of biological chemistry. 1993 ; 268 (4) : 2781-2792.
PMID 8428952
 
Activation of the leukocyte plastin gene occurs in most human cancer cells.
Park T, Chen ZP, Leavitt J
Cancer research. 1994 ; 54 (7) : 1775-1781.
PMID 8137292
 
Interaction of a Dictyostelium member of the plastin/fimbrin family with actin filaments and actin-myosin complexes.
Prassler J, Stocker S, Marriott G, Heidecker M, Kellermann J, Gerisch G
Molecular biology of the cell. 1997 ; 8 (1) : 83-95.
PMID 9017597
 

Citation

This paper should be referenced as such :
Galiögue-Zouitina, S
LCP1 (lymphocyte cytosolic protein1)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(2):36-36.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/LCP1ID95.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(3;13)(q27;q14) LCP1/BCL6
t(3;13)(q27;q14) BCL6/LCP1
3q27 rearrangements (BCL6) in non Hodgkin lymphoma::t(3;Var)(q27;Var) in non Hodgkin lymphoma
t(3;13)(q27;q14) LCP1/BCL6
t(3;14)(q27;q32) IGH/BCL6::t(2;3)(p12;q27) IGK/BCL6::t(3;22)(q27;q11) IGL/BCL6
t(3;13)(q27;q14) BCL6/LCP1


External links

Nomenclature
Cards
AtlasLCP1ID95.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3936
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:41:17 CEST 2018

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