t(6;22)(p21;q11)

2010-06-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Hematological malignancies.

Note

So far, the t(6;22)(p21;q11) is heterogeneous, and its significance remains problematic.

Phenotype stem cell origin

Four cases availble: one case was a myeloid type blast crisis of chronic myeloid leukemia (CML) in a 36-year-old male patient with a t(9;22)(q34;q11); another case was a CML aberrant translocation t(6;22)(p21;q11) without apparent involvement of chromosome 9 in a 44-year-old male patient; a third case was that of a B-cell precursor (CD10+) L1- acute lymphoblastic leukemia in a 2-year-old girl who was still in complete remission 72 months after diagnosis. A cryptic 5 ETV6 - 3 RUNX1 was found; there were accompanying anomalies, of which a +10 and a +21; the last case was a chronic lymphocytic leukemia (CLL) stage C with also a del(11q), and a del(13q).

Genes Involved and Proteins

Note
Genes involved, if any, are unknown.

Article Bibliography

Pubmed IDLast YearTitleAuthors
89137301996Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia.Fears S et al
38553711985Philadelphia chromosome (Ph) positive chronic myelocytic leukemia (CML): frequency of additional findings.Gödde-Salz E et al
161793742006Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.Mayr C et al
153503032004Effect of interferon-alpha on chromosome abnormalities in treated chronic myelogenous leukemia patients.Tanaka H et al

Summary

Atlas Image
t(6;22)(p21;q11) G-banding and FISH - Courtesy Claudia Haferlach.

Citation

Jean-Loup Huret

t(6;22)(p21;q11)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/haematological/1563/cancer-prone-explorer/css/gene-fusions-explorer/