TAL1 (T-cell acute leukemia 1)
1998-03-01 Marie-Claude Labastie , Jean-Loup Huret AffiliationInstitut dEmbryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France
Identity
HGNC
LOCATION
1p33
LOCUSID
ALIAS
SCL,TCL5,bHLHa17,tal-1
FUSION GENES
DNA/RNA
DNA diagram
Description
8 exons; 16 kb; SIL (a different gene) sits 90 kb further in 5
Transcription
(complex) alternate splicing of: 1A with 2A, or 3 vs 1B, 2B,3 ...or directly 4, 5, 6
Proteins
Description
331 amino acids for the major form of 48 KDa; a truncated form of 26 KDa only in some T-ALL; domains: prolin rich in N-trem; poly Gly; basic Helix-Loop-Helix from the exon 6.
Expression
in hematopoietic stem cells, erythroid and megakaryocytic lineages of the adult and in the embryonic brain; indispensable for the genesis of the hematopoietic system.
Function
Implicated in
Entity name
Disease
T-cell ALL
Prognosis
is not too poor, compared to other T-ALL
Entity name
Disease
found in 10 to 30 % of T-ALL with a normal karyotype
Hybrid gene
deletions which place SIL (SCL interrupting sequence) in close 5 of TAL1; hybrid gene with exon 1 from SIL.
Fusion protein
TAL1 is under the promoter sequences controle of SIL, a gene active during T cell development.
Disease
T-cell ALL
Breakpoints
Note
mainly in 5 in a 1 kb region; but also dispersed in rare cases
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8471769 | 1993 | Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. | Bash RO et al |
| 8760303 | 1996 | The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation. | Hofmann TJ et al |
| 9020185 | 1997 | Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. | Ono Y et al |
| 7568177 | 1995 | Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. | Osada H et al |
| 8689686 | 1996 | The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. | Porcher C et al |
| 7957052 | 1994 | Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. | Wadman I et al |
Other Information
Locus ID:
NCBI: 6886
MIM: 187040
HGNC: 11556
Ensembl: ENSG00000162367
Variants:
dbSNP: 6886
ClinVar: 6886
TCGA: ENSG00000162367
COSMIC: TAL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162367 | ENST00000294339 | P17542 |
| ENSG00000162367 | ENST00000371884 | P17542 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38102337 | 2024 | Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. | 1 |
| 38102337 | 2024 | Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. | 1 |
| 36632736 | 2023 | TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer. | 2 |
| 36632736 | 2023 | TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer. | 2 |
| 33664368 | 2021 | Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL). | 9 |
| 34075404 | 2021 | Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. | 17 |
| 33664368 | 2021 | Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL). | 9 |
| 34075404 | 2021 | Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. | 17 |
| 32086528 | 2020 | Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. | 12 |
| 32593672 | 2020 | The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2. | 3 |
| 32633635 | 2020 | MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia. | 7 |
| 32835548 | 2020 | SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome. | 4 |
| 33177556 | 2020 | Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1. | 7 |
| 33293632 | 2020 | The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis. | 5 |
| 32086528 | 2020 | Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. | 12 |
Citation
Marie-Claude Labastie ; Jean-Loup Huret
TAL1 (T-cell acute leukemia 1)
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/gene/15
Historical Card
1997-08-01 TAL1 (T-cell acute leukemia 1) by Jean-Loup Huret,Marie-Claude Labastie Affiliation
Institut dEmbryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France
