Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. leticiafa@fmrp.usp.br
UHMK1 (also known as KIS) is a serine\/threonine kinase initially identified as a Stathmin interacting protein. UHMK1 is characterized by an N-terminal kinase domain and a C-terminal UHM motif. Through the UHM motif, the protein is capable of interacting with splicing factors, such as SF1 and SF3B1, involved in early steps of spliceosome assembly. UHMK1 is ubiquitously but preferentially expressed in the developing nervous system, where it plays a role in mRNA processing, translational enhancing, neurite outgrowth and postsynaptic plasticity. Protein interactions between UHMK1 and a range of proteins pointed to its function in different cellular processes, such as RNA metabolism, cell cycle progression, cell migration and membrane trafficking. More recently, a role of UHMK1 in cell differentiation has also been proposed.
NCBI: 127933 MIM: 608849 HGNC: 19683 Ensembl: ENSG00000152332
dbSNP: 127933 ClinVar: 127933 TCGA: ENSG00000152332 COSMIC: UHMK1
Vanessa Cristina Arfelli ; Leticia Fröhlich Archangelo
UHMK1 (U2AF homology motif kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-11-01
Online version: http://atlasgeneticsoncology.org/gene/41071/teaching-explorer/js/lib/js/template.js