Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. email@example.com
PIMREG (FAM64) was initially identified as CATS, the CALM (PICALM) interacting protein expressed in thymus and spleen. Mounting evidence suggests the involvement of FAM64A in tumorigenesis. Through interaction with PICALM, FAM64 was able to influence the subcellular localization of the leukemic fusion protein PICALM\/MTT10 (CALM\/AF10). FAM64A is highly expressed in leukemia, lymphoma and tumor cell lines and its levels are strongly correlated with cellular proliferation in both malignant and normal cells. FAM64A is a mitotic regulator that controls chromosome segregation during cell division, and its transcripts covariate with that of cell cycle regulation genes in tumorigenesis. Nevertheless, a precise role of FAM64A in tumorigenesis is yet to be defined.
Leticia Fröhlich Archangelo
PIMREG (PICALM interacting mitotic regulator)
Atlas Genet Cytogenet Oncol Haematol. 2017-01-01
Online version: http://atlasgeneticsoncology.org/gene/54310/pimreg-(picalm-interacting-mitotic-regulator)