MAD1L1 is coiled-coil protein that binds to improperly attached kinetochrore, what results in recruitment and interaction with MAD2L1, activation of the mitotic checkpoint complex, inhibition of the anaphase-promoting complex\/cyclosome and cell cycle arrest. During interphase, MAD1L1 regulates mitosis entrance at nuclear pore complexes (MAD2L1-dependent mechanism) and Golgi apparatus-related functions (MAD2L1-independent mechanism). Alterations in MAD1L1 are associated with chromosomal instability, aneuploidy, and cancer susceptibility. The present review contains data on MAD1L1 DNA, RNA, protein encoded and function.
vs. P. troglodytes
vs. M. mulatta
vs. C. lupus
vs. B. taurus
vs. M. musculus
vs. R. norvegicus
vs. G. gallus
vs. X. tropicalis
vs. D. rerio
vs. D. melanogaster
vs. A. gambiae
NCBI: 8379 MIM: 602686 HGNC: 6762 Ensembl: ENSG00000002822
dbSNP: 8379 ClinVar: 8379 TCGA: ENSG00000002822 COSMIC: MAD1L1
Keli Lima ; Joao Agostinho Machado-Neto
MAD1L1 (mitotic arrest deficient 1 like 1)
Atlas Genet Cytogenet Oncol Haematol. 2018-02-01
Online version: http://atlasgeneticsoncology.org/gene/41226/tumors-explorer/favicon/css/template-card.css