Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA (NDR); Department of Pathology, University of Pennsylvania Health System, Philadelphia, PA, USA (PZ)
Post translational modifications:
- Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter.
- Phosphorylation at Ser-180 and Ser-516 by MAPK and RPS6KA1 activate the transcription factor activity and promote ubiquitiniation and subsequent degradation.
- Can be deubiquitinated by USP13, preventing its degradation.
Nicole D Riddle ; Paul Zhang
MITF (microphthalmia-associated transcription factor)
Atlas Genet Cytogenet Oncol Haematol. 2013-04-01
Online version: http://atlasgeneticsoncology.org/gene/44193/mitf-(microphthalmia-associated-transcription-factor)