The gene is on the plus strand and encompasses 35 kb of DNA. The exon number of gene is 3 and parts of the second and third exons encode the protein (ENSP00000302543).

1447 bp long mRNA; 969 bp long open reading frame.

No reported pseudogenes.

CXXC5 encodes a 322 amino-acid protein with a molecular mass of 33 kDa. Amino-acid sequence suggests that CXXC5 contains a number of phosphorylation and acetylation sites. By homology, CXXC5 is considered to be a member of CXXC-type zinc finger protein family, which binds to non-methylated CpG dinuclotide containing DNA.

CXXC5 is expressed in various tissues.

CXXC5 protein is mainly in the nucleus. CXXC5 protein may also be localized in the cytoplasm coupled with Dishevelled (Dvl) protein (Andersson et al., 2009).

CXXC5 can be induced by retinoid signaling and is required for myelopoiesis (Pendino et al., 2009). CXXC5 protein is involved in the DNA-damage induced p53 activation as well as in the regulation of cell cycle and apoptosis (Zhang et al., 2009). CXXC5 protein participates in the TNF-a-induced apoptosis through association with SMAD (Wang et al., 2013). CXXC5 protein is a critical modulator of BMP4-regulated Wnt-signaling in neural stem cells (Andersson et al., 2009). CXXC5 protein is shown to repress TET2 gene expression (Ko et al., 2013).

CXXC domain is a highly conserved domain of a class of proteins that interact with non-methylated CpG dinucleotides (CpGs). The CXXC domain of CXXC5 displays a significant homology to CXXC domains of CXXC4 and TET3 proteins (Ko et al., 2013).

Not defined yet.