t(1;14)(q21;q32) BCL9/IGH
t(1;22)(q21;q11) IGL/BCL9

2004-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL)

Epidemiology

a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient

Prognosis

prognosis was poor in 2 cases

Genes Involved and Proteins

Gene name
BCL9 (B-cell CLL/lymphoma 9)
Location
1q21.2
Protein description
involved in Wnt signal transduction
Gene name
IGL (Immunoglobulin Lambda)
Location
22q11.22
Note
Immunoglobulin genesImmunoglobulin genes

Bibliography

Pubmed IDLast YearTitleAuthors
94906691998Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.Willis TG et al

Summary

Fusion gene

IGL/BCL9 IGL (22q11.22) BCL9 (1q21.2) M t(1;22)(q21;q11)

Note

the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other
This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement.

Citation

Jean-Loup Huret

t(1;14)(q21;q32) BCL9/IGH
t(1;22)(q21;q11) IGL/BCL9

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1319/t(1;14)(q21;q32)

External Links