t(11;19)(q13;p13) FSTL3/CCND1
2015-02-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Abstract
Review on t(11;19)(q13;p13) FSTL3/CCND1, with data on clinics, and the genes involved.
Clinics and Pathology
Disease
B-cell chronic lymphocytic leukemia (B-CLL)
Epidemiology
Only one case to date, a 67 year-old female patient (Rimokh et al., 1993; Hayette et al., 1998).
Prognosis
No data
Genes Involved and Proteins
Gene name
CCND1 (B-cell leukemia/lymphoma 1)
Location
11q13.3
Protein description
Binds and activates the G1 cyclin dependent kinases; Phosphorylates SMAD3 and inhibits its transcriptional activity and antiproliferative function.
Gene name
FSTL3 (follistatin-like 3 (secreted glycoprotein))
Location
19p13.3
Result of the Chromosomal Anomaly
Description
The breaks occurred at nucleotide 2276 in the 3 untranslated region of the last CCND1 exon, and about 7 kbp upstream of FSTL3.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9671416 | 1998 | FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. | Hayette S et al |
| 8499640 | 1993 | Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias. | Rimokh R et al |
Summary
Fusion gene
FSTL3/CCND1 FSTL3 (19p13.3) CCND1 (11q13.3) M|FSTL3/CCND1 FSTL3 (19p13.3) CCND1 (11q13.3) M t(11;19)(q13;p13)
Citation
Jean-Loup Huret
t(11;19)(q13;p13) FSTL3/CCND1
Atlas Genet Cytogenet Oncol Haematol. 2015-02-01
Online version: http://atlasgeneticsoncology.org/haematological/1527/t(11
