PDGFRB (platelet-derived growth factor receptor, beta polypeptide)

5q32

Comprises an extracellular part with 5 Ig-like C2 type domains, a transmembrane domain, and an intracellular part with a tyrosine kinase domain (made of two tyrosine kinase subdomains) for transduction of the signal. Receptor tyrosine kinase; receptor for PDGFB and PDGFD (Bergsten et al., 2001); forms homodimers, or heterodimer with PDGFRA; upon dimerization, subsequent activation by autophosphorylation of the tyrosine kinase intracellular domains occurs.

CAPRIN1 (cell cycle associated protein 1)

11p13

709 amino acids. Comprises two coiled coil regions (amino acids 60-94 and 125-153) and a G3BP1-binding region (360-381), with, from 372 to 380 (FIQDSMLD), the conserved motif: F(M/I/L)Q(D/E)Sx(I/L)D (Solomon et al., 2007). Cytoplasmic phosphoprotein essential for normal cellular proliferation; CAPRIN1 occurs in messenger ribonucleoprotein particles that also contain RNA binding proteins; CAPRIN1/ G3BP1 complexes occur in RNA granules called cytoplasmic stress granules, which form in stressed cells. CAPRIN1 induces phosphorylation of eIF-2alpha. CAPRIN1 selectively binds mRNA for c-MYC and CCND2 (cyclin D2) (Solomon et al., 2007).