1.Cytogénétique Hématologique, Service d Hématologie Biologique, Hpital Pitié-Salpêtrière, APHP,.Sorbonne Université. Centre de Recherche des Cordeliers, INSERM UMRS_1138, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Paris, France elise.chapiro@aphp.fr; florence.nguyen-khac@psl.aphp.fr2.Cytogénétique Hématologique, Service dHématologie Biologique, Hpital Pitié-Salpêtrière, APHP,.Sorbonne Université. Centre de Recherche des Cordeliers, INSERM UMRS_1138, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Paris, France elise.chapiro@aphp.fr; florence.nguyen-khac@psl.aphp.fr
B-cell prolymphocytic leukemia (B-PLL) is a very rare mature B-cell leukemia occurring in elderly people diagnosed when prolymphocytes comprise more than 55% of the lymphoid cells in peripheral blood. A complex karyotype, MYC gene abnormalities (translocation or more rarely gain/amplification) and 17p deletion including TP53 are frequent. The prognosis is poor.
Florence Nguyen-Khac ; Elise Chapiro
B-cell prolymphocytic leukemia (B-PLL)
Atlas Genet Cytogenet Oncol Haematol. 2021-02-01
Online version: http://atlasgeneticsoncology.org/haematological/2033/js/js/lib/jquery-3.5.1.min.js