As translocation breakpoints near terminal regions of chromosomes are difficult to ascertain, included are cases with 7q35 breakpoints, probably involving TRB.

T-cell acute lymphoblastic leukemia (T-ALL) and angioimmunoblastic T-cell lymphoma (AITL).

T-cell malignancies: 4 patients with T-cell acute lymphoblastic leukemia (Kaneko et al., 1988; Secker-Walker et al., 1992; Cauwelier et al., 2006) and 3 with angioimmunoblastic T-cell lymphoma (AITL) (Cosimi et al., 1990) (Table 1.).
Table 1. Clinical and genetic testing findings in reported patients with t(7;14)(q34-36;q11).

	Sex/Age	Diagnosis	Karyotype/td>
1	M/14	T-ALL	46,XY,t(7;14)(q35;q11)
2	F/18	T-ALL	46,XX,t(7;14)(q34;q11)
3	30/M	T-ALL	46-47,XY,+der(14)t(7;14)(q34;q11),+mar1   TRA-TRD/TRB
4	F/5	T-ALL	45,X,?der(X),t(7;14)(q34;q11),-9,-9,del(11)(p11),del(12)(p?13),+mar   TRA-TRD/TRB
5	F	AITL	46,XX,dup(7)(q11q35),t(7;14)(q35;q11),t(7;7)(p13;q35)   LN
6	F	AITL	46,XX,dup(7)(q11q35),t(7;14)(q35;q11),t(7;14)(p13;q11),add(14)(q11)   LN
7	F	AITL	48,XX,+3,+7,t(7;14)(q35;q11),t(7;14)(p13;q11),t(14;14)(q11;q32)   LN

1. Kaneko et al., 1988; 2. Secker-Walker et al., 1992; 3-4. Cauwelier et al., 2006; 5-7. Cosimi et al., 1990.
Abbreviations: M, male; F, female; AITL, Angioimmunoblastic T-cell lymphoma; LN, lymph node; T-ALL, T-cell Acute lymphoblastic leukemia.

2 female and 1 male patients aged 5, 18 and 30 years old (Secker-Walker et al., 1992; Cauwelier et al., 2006). In addition 1 male (Kaneko et al., 1988) and 3 female patients (Cosimi et al., 1990) with 7q35 breakpoints were reported.

Unknown due to the rarity of reported patients.

Translocations between T-cell receptor genes and various oncogenes are a genetic hallmarks of T-cell malignancies. Chromosomal aberrations affecting TCR gene loci mainly involve TRA/TRD at 14q11.2 and TRB at 7q34 and affect various known oncogenes that most often code for transcription factors or proteins involved in transcriptional complexes, the deregulated expression of which is putatively implicated in T-cell oncogenesis.

TRA/TRB