1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
Pericytes are contractile cells that surround small blood vessel, that can differentiate along smooth muscle lineage (“myopericytes”) or exhibit a “glomoid” phenotypes .1 Glomus tumor (GT), together with myofibroma (MF), myopericytoma (MP), and angioleiomyoma (AL) are members of the pericytic family. However, emerging genetic data across these neoplasms is dissimilar, arguing against a pathogenetically unified family: PDGFRB-mutant MF and MP and NOTCH–fusion-positive GT.2 Recently, group of neoplasms with GLI1 rearrangements/amplification has been reported which show some resemblance to pericytic tumors, without specific immunophenotype. However, classification of this group of neoplasms remains challenging. 3-7
Paola Dal Cin
Pericytic (perivascular) tumors
Atlas Genet Cytogenet Oncol Haematol. 2022-02-18
Online version: http://atlasgeneticsoncology.org/solid-tumor/208938/gene-explorer/js/lib/favicon/favicon-32x32.png