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BCL2 (B-cell leukemia/lymphoma 2)

Written1998-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesregulatory subunit 50
Alias_symbol (synonym)Bcl-2
PPP1R50
Other alias
HGNC (Hugo) BCL2
LocusID (NCBI) 596
Atlas_Id 49
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 63123346 and ends at 63319380 bp from pter ( according to hg19-Feb_2009)  [Mapping BCL2.png]
Fusion genes
(updated 2016)		AFF3 (2q11.2) / BCL2 (18q21.33)ATRX (Xq21.1) / BCL2 (18q21.33)BCL2 (18q21.33) / BCL2 (18q21.33)
BCL2 (18q21.33) / C18orf8 (18q11.2)BCL2 (18q21.33) / HFE2 (1q21.1)BCL2 (18q21.33) / IGH (14q32.33)
BCL2 (18q21.33) / IGL (22q11.22)BCL2 (18q21.33) / Ig ()BCL2 (18q21.33) / Immunoglobulin ()
BCL2 (18q21.33) / TSPO (22q13.2)BCL2 (18q21.33) / VPS4B (18q21.33)BCL6 (3q27.3) / BCL2 (18q21.33)
DHRS12 (13q14.3) / BCL2 (18q21.33)HFE2 (1q21.1) / BCL2 (18q21.33)IGH (14q32.33) / BCL2 (18q21.33)
IGHG1 (14q32.33) / BCL2 (18q21.33)IGK (14q32.33) / BCL2 (18q21.33)IGL (22q11.22) / BCL2 (18q21.33)
IGLV3-10 () / BCL2 (18q21.33)NEDD4L (18q21.31) / BCL2 (18q21.33)NGB (14q24.3) / BCL2 (18q21.33)
ZNF791 (19p13.2) / BCL2 (18q21.33)

DNA/RNA

 
  BCL2 (18q21) PAC 248E24 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Description telomere to centromere orientation; 3 exons; exon 1 and the 3' part of exon 3 are non coding
Transcription 2 alternative transcripts (a and b); 5. 1 kb mRNA; coding sequence: CDS 1459...2178

Protein

Description 25 kDa; 205 amino acids (BCL2b) or 239 amino acids (BCL2a, which has, in addition, a hydrophobic tail for membrane anchorage; this tail seems necessary for anti apoptotic ability); contain homo/heterodimerization domains (BH) and NH domains.
Expression wide; in B and T cells in particular
Localisation mainly in the mitochondrial membrane; other membranes
Function antiapoptosis, through a possibly complex process; dimerization, especially with BAX; role of the BCL2 anti-apoptosis members in forming complexes with caspase-9 and APAF1 (homolog of the nematode CED-4), which prevent them to initiate the protease cascade (through caspase-3 cytochrome C dependent activation and) leading to apoptosis
Homology with Ced9 (nematode C. elegans); with other member of the BCL2 family: 1- apoptosis inhibitors BCLX, MCL1, and 2- apoptosis inducers BAX, BAD, BIK, ...

Implicated in

Note
  
Entity t(14;18)(q32;q21)/B-cell malignancies --> IgH - BCL2
Disease B- cell NHL mainly; found in 80 to 90 % of follicular lymphomas, 30% of diffuse large cell lymphomas
Prognosis according to the cyto-pathologic subtype (small cleaved cell follicular lymphomas have a good prognosis; large cell lymphomas have a worse prognosis; the t(14;18) may have no prognostic significance)
Cytogenetics complex karyotypes are frequent with +7, del(6q), +12, + X,...
Hybrid/Mutated Gene 5' BCL2 translocated on chromosome 14 near JH (junctions genes of IgH) and C in 3'
Abnormal Protein no fusion protein, but promoter exchange; the immunoglobulin gene enhancer stimulates the expression of BCL2
Oncogenesis as BCL2 is an apoptosis inhibitor, cell death is delayed, and there is cell accumulation (more than real transformation)
  
  
Entity chronic lymphocytic leukaemia
Oncogenesis BCL2 is hypomethylated in the promotor region, and, therefore, overexpressed
  

Breakpoints

 

Bibliography

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.
Bakhshi A, Jensen JP, Goldman P, Wright JJ, McBride OW, Epstein AL, Korsmeyer SJ
Cell. 1985 ; 41 (3) : 899-906.
PMID 3924412
 
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.
Cleary ML, Sklar J
Proceedings of the National Academy of Sciences of the United States of America. 1985 ; 82 (21) : 7439-7443.
PMID 2865728
 
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Hu Y, Benedict MA, Wu D, Inohara N, Nez G
Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (8) : 4386-4391.
PMID 9539746
 
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Oltvai ZN, Milliman CL, Korsmeyer SJ
Cell. 1993 ; 74 (4) : 609-619.
PMID 8358790
 
Structure, function, and regulation of human cAMP-dependent protein kinases.
Taskén K, Skålhegg BS, Taskén KA, Solberg R, Knutsen HK, Levy FO, Sandberg M, Orstavik S, Larsen T, Johansen AK, Vang T, Schrader HP, Reinton NT, Torgersen KM, Hansson V, Jahnsen T
Advances in second messenger and phosphoprotein research. 1997 ; 31 : 191-204.
PMID 9344252
 

Citation

This paper should be referenced as such :
Huret, JL
BCL2 (B-cell leukemia/lymphoma 2)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(4):113-114.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/BCL2ID49.html

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 22 ]
  3q27 rearrangements (BCL6) in non Hodgkin lymphoma::t(3;Var)(q27;Var) in non Hodgkin lymphoma
Classification of B-cell non-Hodgkin lymphomas (NHL)
Burkitt's lymphoma (BL)
del(13q) in chronic lymphocytic leukemia
Double Hit Lymphoma (DHL)::Triple Hit Lymphoma (THL)
Follicular lymphoma (FL)
i(18)(q10)
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
HIV-associated lymphomas
Pediatric-type Follicular Lymphoma
t(1;1)(p36;q21) in Non Hodgkin Lymphoma
t(1;14)(q21;q32) FCGR2B/IGH
t(2;18)(q11;q21) AFF3/BCL2
t(4;11)(q21;q23) KMT2A/AFF1
t(7;19)(q34;p13) TRB/LYL1
t(8;14)(q24;q32) IGH/MYC::t(2;8)(p12;q24) IGK/MYC::t(8;22)(q24;q11) IGL/MYC
t(14;15)(q32;q11) IGH/NBEAP1
t(14;18)(q32;q21) IGH/BCL2::t(2;18)(p11;q21) IGK/BCL2::t(18;22)(q21;q11) IGL/BCL2
t(20;21)(q13.2;q22.12) ZFP64/RUNX1
T-cell/histiocyte rich large B-cell lymphoma
+18 or trisomy 18 in lymphoproliferative disorders
Histiocyte-rich B-cell lymphoma

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 9 ]
  Thyroid: Anaplastic (undifferentiated) carcinoma
Neuro-Endocrine/Endocrine System: Carcinoid tumors
Soft Tissues: Desmoid-type fibromatosis
Liver tumors: an overview
Bone: Osteochondroma
Ovary: Choriocarcinoma
Ovary: Epithelial tumors
Penile tumors: an overview
Eye: Posterior uveal melanoma

External links

Nomenclature
HGNC (Hugo)BCL2   990
Cards
AtlasBCL2ID49
Entrez_Gene (NCBI)BCL2  596  BCL2, apoptosis regulator
AliasesBcl-2; PPP1R50
GeneCards (Weizmann)BCL2
Ensembl hg19 (Hinxton)ENSG00000171791 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171791 [Gene_View]  chr18:63123346-63319380 [Contig_View]  BCL2 [Vega]
ICGC DataPortalENSG00000171791
TCGA cBioPortalBCL2
AceView (NCBI)BCL2
Genatlas (Paris)BCL2
WikiGenes596
SOURCE (Princeton)BCL2
Genetics Home Reference (NIH)BCL2
Genomic and cartography
GoldenPath hg38 (UCSC)BCL2  -     chr18:63123346-63319380 -  18q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCL2  -     18q21.33   [Description]    (hg19-Feb_2009)
EnsemblBCL2 - 18q21.33 [CytoView hg19]  BCL2 - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBIBCL2 [Mapview hg19]  BCL2 [Mapview hg38]
OMIM151430   
Gene and transcription
Genbank (Entrez)AF401211 AI401297 BC027258 DQ891470 DQ894654
RefSeq transcript (Entrez)NM_000633 NM_000657
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BCL2
Cluster EST : UnigeneHs.150749 [ NCBI ]
CGAP (NCI)Hs.150749
Alternative Splicing GalleryENSG00000171791
Gene ExpressionBCL2 [ NCBI-GEO ]   BCL2 [ EBI - ARRAY_EXPRESS ]   BCL2 [ SEEK ]   BCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)BCL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)596
GTEX Portal (Tissue expression)BCL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10415   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10415  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10415
Splice isoforms : SwissVarP10415
PhosPhoSitePlusP10415
Domaine pattern : Prosite (Expaxy)BCL2_FAMILY (PS50062)    BH1 (PS01080)    BH2 (PS01258)    BH3 (PS01259)    BH4_1 (PS01260)    BH4_2 (PS50063)   
Domains : Interpro (EBI)Apop_reg_Bcl2    Bcl2-like    Bcl2/BclX    Bcl2_BH1_motif_CS    Bcl2_BH2_motif_CS    Bcl2_BH3_motif_CS    Bcl2_BH4    Bcl2_BH4_motif_CS    Blc2_fam   
Domain families : Pfam (Sanger)Bcl-2 (PF00452)    BH4 (PF02180)   
Domain families : Pfam (NCBI)pfam00452    pfam02180   
Domain families : Smart (EMBL)BH4 (SM00265)  
Conserved Domain (NCBI)BCL2
DMDM Disease mutations596
Blocks (Seattle)BCL2
PDB (SRS)1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
PDB (PDBSum)1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
PDB (IMB)1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
PDB (RSDB)1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
Structural Biology KnowledgeBase1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
SCOP (Structural Classification of Proteins)1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
CATH (Classification of proteins structures)1G5M    1GJH    1YSW    2O21    2O22    2O2F    2W3L    2XA0    4AQ3    4IEH    4LVT    4LXD    4MAN    5AGW    5AGX    5FCG    5JSN   
SuperfamilyP10415
Human Protein AtlasENSG00000171791
Peptide AtlasP10415
HPRD01045
IPIIPI00020961   IPI00217817   
Protein Interaction databases
DIP (DOE-UCLA)P10415
IntAct (EBI)P10415
FunCoupENSG00000171791
BioGRIDBCL2
STRING (EMBL)BCL2
ZODIACBCL2
Ontologies - Pathways
QuickGOP10415
Ontology : AmiGOprotein polyubiquitination  ossification  ovarian follicle development  metanephros development  branching involved in ureteric bud morphogenesis  behavioral fear response  B cell homeostasis  release of cytochrome c from mitochondria  release of cytochrome c from mitochondria  regulation of cell-matrix adhesion  protease binding  lymphoid progenitor cell differentiation  B cell lineage commitment  response to ischemia  renal system process  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  protein dephosphorylation  melanin metabolic process  regulation of nitrogen utilization  apoptotic process  humoral immune response  cellular response to DNA damage stimulus  actin filament organization  axonogenesis  female pregnancy  cell aging  transcription factor binding  male gonad development  extrinsic apoptotic signaling pathway via death domain receptors  intrinsic apoptotic signaling pathway in response to oxidative stress  response to radiation  response to toxic substance  post-embryonic development  response to iron ion  response to UV-B  response to gamma radiation  regulation of gene expression  negative regulation of autophagy  negative regulation of calcium ion transport into cytosol  regulation of glycoprotein biosynthetic process  mesenchymal cell development  positive regulation of neuron maturation  positive regulation of smooth muscle cell migration  channel activity  membrane  cell growth  channel inhibitor activity  single organismal cell-cell adhesion  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  cochlear nucleus development  gland morphogenesis  regulation of transmembrane transporter activity  negative regulation of ossification  positive regulation of cell growth  negative regulation of cell growth  melanocyte differentiation  negative regulation of cell migration  positive regulation of B cell proliferation  hair follicle morphogenesis  axon regeneration  ubiquitin protein ligase binding  regulation of protein stability  nuclear membrane  endoplasmic reticulum calcium ion homeostasis  glomerulus development  negative regulation of cellular pH reduction  negative regulation of myeloid cell apoptotic process  T cell differentiation in thymus  positive regulation of peptidyl-serine phosphorylation  negative regulation of osteoblast proliferation  response to cytokine  response to nicotine  organ growth  positive regulation of multicellular organism growth  B cell proliferation  cellular response to glucose starvation  response to drug  response to drug  response to hydrogen peroxide  identical protein binding  protein homodimerization activity  T cell homeostasis  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of catalytic activity  myelin sheath  protein complex  CD8-positive, alpha-beta T cell lineage commitment  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  negative regulation of neuron apoptotic process  sequence-specific DNA binding  ear development  regulation of viral genome replication  positive regulation of melanocyte differentiation  negative regulation of retinal cell programmed cell death  regulation of mitochondrial membrane permeability  pore complex  protein heterodimerization activity  focal adhesion assembly  spleen development  thymus development  digestive tract morphogenesis  oocyte development  positive regulation of skeletal muscle fiber development  pigment granule organization  homeostasis of number of cells within a tissue  B cell receptor signaling pathway  response to glucocorticoid  neuron apoptotic process  BH3 domain binding  defense response to virus  protein phosphatase 2A binding  regulation of mitochondrial membrane potential  negative regulation of mitochondrial depolarization  regulation of calcium ion transport  transmembrane transport  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to organic substance  cellular response to hypoxia  reactive oxygen species metabolic process  extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  negative regulation of reactive oxygen species metabolic process  negative regulation of anoikis  negative regulation of apoptotic signaling pathway  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of intrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein polyubiquitination  ossification  ovarian follicle development  metanephros development  branching involved in ureteric bud morphogenesis  behavioral fear response  B cell homeostasis  release of cytochrome c from mitochondria  release of cytochrome c from mitochondria  regulation of cell-matrix adhesion  protease binding  lymphoid progenitor cell differentiation  B cell lineage commitment  response to ischemia  renal system process  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  protein dephosphorylation  melanin metabolic process  regulation of nitrogen utilization  apoptotic process  humoral immune response  cellular response to DNA damage stimulus  actin filament organization  axonogenesis  female pregnancy  cell aging  transcription factor binding  male gonad development  extrinsic apoptotic signaling pathway via death domain receptors  intrinsic apoptotic signaling pathway in response to oxidative stress  response to radiation  response to toxic substance  post-embryonic development  response to iron ion  response to UV-B  response to gamma radiation  regulation of gene expression  negative regulation of autophagy  negative regulation of calcium ion transport into cytosol  regulation of glycoprotein biosynthetic process  mesenchymal cell development  positive regulation of neuron maturation  positive regulation of smooth muscle cell migration  channel activity  membrane  cell growth  channel inhibitor activity  single organismal cell-cell adhesion  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  cochlear nucleus development  gland morphogenesis  regulation of transmembrane transporter activity  negative regulation of ossification  positive regulation of cell growth  negative regulation of cell growth  melanocyte differentiation  negative regulation of cell migration  positive regulation of B cell proliferation  hair follicle morphogenesis  axon regeneration  ubiquitin protein ligase binding  regulation of protein stability  nuclear membrane  endoplasmic reticulum calcium ion homeostasis  glomerulus development  negative regulation of cellular pH reduction  negative regulation of myeloid cell apoptotic process  T cell differentiation in thymus  positive regulation of peptidyl-serine phosphorylation  negative regulation of osteoblast proliferation  response to cytokine  response to nicotine  organ growth  positive regulation of multicellular organism growth  B cell proliferation  cellular response to glucose starvation  response to drug  response to drug  response to hydrogen peroxide  identical protein binding  protein homodimerization activity  T cell homeostasis  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of catalytic activity  myelin sheath  protein complex  CD8-positive, alpha-beta T cell lineage commitment  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  negative regulation of neuron apoptotic process  sequence-specific DNA binding  ear development  regulation of viral genome replication  positive regulation of melanocyte differentiation  negative regulation of retinal cell programmed cell death  regulation of mitochondrial membrane permeability  pore complex  protein heterodimerization activity  focal adhesion assembly  spleen development  thymus development  digestive tract morphogenesis  oocyte development  positive regulation of skeletal muscle fiber development  pigment granule organization  homeostasis of number of cells within a tissue  B cell receptor signaling pathway  response to glucocorticoid  neuron apoptotic process  BH3 domain binding  defense response to virus  protein phosphatase 2A binding  regulation of mitochondrial membrane potential  negative regulation of mitochondrial depolarization  regulation of calcium ion transport  transmembrane transport  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to organic substance  cellular response to hypoxia  reactive oxygen species metabolic process  extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  negative regulation of reactive oxygen species metabolic process  negative regulation of anoikis  negative regulation of apoptotic signaling pathway  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of intrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
REACTOMEP10415 [protein]
REACTOME PathwaysR-HSA-844455 [pathway]   
NDEx NetworkBCL2
Atlas of Cancer Signalling NetworkBCL2
Wikipedia pathwaysBCL2
Orthology - Evolution
OrthoDB596
GeneTree (enSembl)ENSG00000171791
Phylogenetic Trees/Animal Genes : TreeFamBCL2
HOVERGENP10415
HOGENOMP10415
Homologs : HomoloGeneBCL2
Homology/Alignments : Family Browser (UCSC)BCL2
Gene fusions - Rearrangements
Fusion : MitelmanAFF3/BCL2 [2q11.2/18q21.33]  [t(2;18)(q11;q21)]  
Fusion : MitelmanATRX/BCL2 [Xq21.1/18q21.33]  [t(X;18)(q21;q21)]  
Fusion : MitelmanIGH/BCL2 [14q32.33/18q21.33]  [t(14;18)(q32;q21)]  [t(3;14;18)(q27;q32;q21)]  
[t(8;14;18)(q24;q32;q21)]  
Fusion : MitelmanIGK/BCL2 [2p11.2/18q21.33]  [t(2;18)(p11;q21)]  
Fusion : MitelmanIGL/BCL2 [22q11.22/18q21.33]  [t(18;22)(q21;q11)]  
Fusion : MitelmanNEDD4L/BCL2 [18q21.31/18q21.33]  [t(18;18)(q21;q21)]  
Fusion: TCGAATRX Xq21.1 BCL2 18q21.33 LGG
Fusion: TCGANEDD4L 18q21.31 BCL2 18q21.33 BRCA
Fusion : TICdbAFF3 [2q11.2]  -  BCL2 [18q21.33]
Fusion : TICdbBCL2 [18q21.33]  -  Ig []
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BCL2
dbVarBCL2
ClinVarBCL2
1000_GenomesBCL2 
Exome Variant ServerBCL2
ExAC (Exome Aggregation Consortium)BCL2 (select the gene name)
Genetic variants : HAPMAP596
Genomic Variants (DGV)BCL2 [DGVbeta]
DECIPHERBCL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBCL2 
Mutations
ICGC Data PortalBCL2 
TCGA Data PortalBCL2 
Broad Tumor PortalBCL2
OASIS PortalBCL2 [ Somatic mutations - Copy number]
Cancer Gene: CensusBCL2 
Somatic Mutations in Cancer : COSMICBCL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBCL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch BCL2
DgiDB (Drug Gene Interaction Database)BCL2
DoCM (Curated mutations)BCL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BCL2 (select a term)
intoGenBCL2
NCG5 (London)BCL2
Cancer3DBCL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151430   
Orphanet8750    13856   
MedgenBCL2
Genetic Testing Registry BCL2
NextProtP10415 [Medical]
TSGene596
GENETestsBCL2
Target ValidationBCL2
Huge Navigator BCL2 [HugePedia]
snp3D : Map Gene to Disease596
BioCentury BCIQBCL2
ClinGenBCL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD596
Chemical/Pharm GKB GenePA25302
Clinical trialBCL2
Miscellaneous
canSAR (ICR)BCL2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBCL2
EVEXBCL2
GoPubMedBCL2
iHOPBCL2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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