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LRP1B (low density lipoprotein receptor-related protein 1B)

Written2013-07Hugo Prazeres, Catarina Salgado, Cecília Duarte, Paula Soares
Institute of Molecular Pathology, Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal

(Note : for Links provided by Atlas : click)

Identity

Alias_nameslow density lipoprotein receptor-related protein 1B
Alias_symbol (synonym)LRP-DIT
LRPDIT
Other alias
HGNC (Hugo) LRP1B
LocusID (NCBI) 53353
Atlas_Id 41200
Location 2q22.1  [Link to chromosome band 2q22]
Location_base_pair Starts at 140231427 and ends at 142131701 bp from pter ( according to hg19-Feb_2009)  [Mapping LRP1B.png]
Local_order Centromere ... - HNMT - SPOPL - NXPH2 - LRP1B - KYNU - ARHGAP15 - GTDC1 - ZEB - ... qter
 
  Mapping diagram.
Fusion genes
(updated 2016)		LRP1B (2q22.1) / ATP1A3 (19q13.2)LRP1B (2q22.1) / DMD (Xp21.2)LRP1B (2q22.1) / GULP1 (2q32.1)
LRP1B (2q22.1) / HECW2 (2q32.3)LRP1B (2q22.1) / KCNH8 (3p24.3)LRP1B (2q22.1) / NAV3 (12q21.2)
MALAT1 (11q13.1) / LRP1B (2q22.1)TXNL1 (18q21.31) / LRP1B (2q22.1)
Note LRP1B is encoded in the long arm of chromosome 2, from the minus strand.

DNA/RNA

 
  DNA diagram. Overview of sequence-related elements in the LRP1B gene. The gene comprises 91 exons, an upstream CpG-enriched region, an element for the P300 transcription factor (within intron 1) and a downstream 3' UTR sequence which encodes a mRNA binding site for miR-548a-5p.
Description LRP1B genomic sequence spans 1.9 Mbs, with a genetic structure composed of 91 exons that comprise 16.5 Kbs of coding sequence (Liu et al., 2000b). Intron 1 is very large and contains a functionally validated binding site for the P300 Histone Acetyltransferase transcription factor (Prazeres et al., 2011). A CpG enriched region spans the 5' UTR, exon 1 and upstream sequence of intron 1 (Sonoda et al., 2004; Prazeres et al., 2011). The 3' UTR encodes sequences that are several predicted microRNA binding sites. Functional studies validated binding of miR-548a-5p (Prazeres et al., 2011).
Transcription Expression is epigenetically regulated, both by DNA methylation and presumably by histone modification. This comes from finding of promoter hypermethylation in several types of cancer (Sonoda et al., 2004; Nakagawa et al., 2006; Rahmatpanah et al., 2006; Taylor et al., 2007a; Taylor et al., 2007b; Lu et al., 2010) with demethylation agents such as 5-azacytidine or siRNA for DNMT1 results in LRP1B re-expression (Sonoda et al., 2004; Prazeres et al., 2011). Also, treatment with Histone Deacetylase Inhibitors, such as Tricostatin A, induces expression of LRP1B (Sonoda et al., 2004; Prazeres et al., 2011).
Transcripts with alternative C-terminal result from alternative splicing of exon 90, which impact differential binding of partners interacting with the cytoplasmic domain of LRP1B (Shiroshima et al., 2009).
Pseudogene No LRP1B pseudogene is annotated.

Protein

 
  Protein diagram. LRP1B is composed of modular domains, namely extracellular cysteine ligand-binding repeats (CRs) and epidermal growth factor precursor-like domains with β-propeller structure, single pass transmembrane region and cytoplasmatic domains with endocytosis NPXY motifs that are nonetheless homologous to other LDL Receptor Family members, for which the prototypic member is the LDL Receptor. The specificity in LRP1B structure comes from the number and organization of these modules.
Description Like other members of the LDL receptor family, the modular structures within LRP1B include an extracellular region with interspersed cysteine-rich complement-type repeats (CRs) and EGF repeats with β-propeller structure, a transmembrane domain and a cytoplasmic domain with endocytosis NPXY motifs. In what concerns the specific structure of LRP1B, it has four putative ligand-binding clusters (I, II, III, and IV, from the amino terminus) that consist of 2, 8, 10, and 12 CRs, respectively. These domain clusters are separated from one another by three clusters of EGF precursor repeats and (F/Y) WXD spacer repeats. LRP1B contains a putative furin endopeptidase processing site (REKR) at positions 3954-3957 (Willnow et al., 1999). This post-translational processing event results in the formation of mature LRP as a noncovalently associated heterodimer, consisting of an extracellular 515-kDa subunit and a transmembrane 85-kDa subunit. The transmembrane domain of LRP1B is separated from domain IV and by a cassette of six epidermal growth factor-like precursor repeats. The cytoplasmic tail of LRP1B contains two NPXY motifs. Between these two, there is a unique insertion of 33 amino acid residues contributed by exon 90 (Willnow et al., 1999).
Expression LRP1B is expressed at higher levels in the central nervous system, thyroid, skeletal muscle and testis. In other organs lower expression levels are detected (Haas et al., 2011).
Localisation LRP1B expression localizes to the cell membrane as well as to several categories of membrane vesicles involved in intracellular traffic. Proteomic analysis has also detected LRP1B in extracellular vesicles, namely as a component of exosomes (Looze et al., 2009). Soluble LRP1B ectodomains may be released to the extracellular milieu through the action of shedases and exert anchorage independent functions (Dietrich et al., 2010).
Function The modular protein domains of Lipoprotein Receptors (LRs) account for three important properties. First, individual LRs have been shown to recognize multiple (more then 30) structurally unrelated extracellular ligands, that include lipoprotein complexes but also many other categories of molecules. Second, LRs are capable of engaging endocytosis, resulting in clearance of their ligands from the extracellular milieu. Third, LRs can associate with other membrane bound receptors, such as integrins and receptor tyrosine kinases, and with intracellular signaling molecules. The classical roles of LRPs are to act as scavenger receptors in the clearance of a myriad of extracellular ligands from the pericellular environment (Herz and Strickland, 2001; May et al., 2007). The best studied ligands of LRs include lipoprotein complexes and proteinase/proteinase inhibitor complexes, such as α2 macroglobulin and members of the urokinase Plasminogen Activating (uPA) system (uPA, uPAR and PAI-1) (Herz et al., 1992; Nykjaer et al., 1992).

LRP1B functions at the extracellular and cell membrane levels:
In order to characterize LRP1B ligands, immobilized recombinant extracellular sub-domains of LRP1B have been used as decoys to perform affinity chromatography using brain lysates (Liu et al., 2001) or in serum (Haas et al., 2011) as a source of potential physiological ligands. Using this strategy, LRP1B has been previously found to bind lipoproteins and ligands of the uPA system (Liu et al., 2001; Li et al., 2002; Knisely et al., 2007). Also several serum proteins, including fibrinogen and apoE-carrying lipoproteins showed affinity to LRP1B extracellular regions (Haas et al., 2011). It should nevertheless be noted that these approaches inherently under-estimate the full impact of LRP1B activity since, in the former study (Liu et al., 2001), the proteome which has been interrogated was derived from brain-lysate fractions, rather than the extracellular proteome which shares the physiological milieu with LRP1B. In the latter study (Haas et al., 2011), the use of serum restricts candidate ligands to systemic circulating factors and neglects local factors that may play a role in the tissue microenvironment. Evidence that LRP1B activity may, directly or indirectly, modulate the abundance of multiple extracellular factors comes from the analysis of conditioned media from LRP1B overexpressing cells, relative to their parental counterparts. Conditioned media from cells overexpressing LRP1B shows a reduction in the amounts of MMP2 as well as other metalloproteinases, growth factors, cytokines and angiogenic factors, indicating that LRP1B impacts the overall extracellular proteome (Prazeres et al., 2011). It is thus expected that LRP1B, in analogy with other LRs, can displays a myriad of additional extracellular ligands that impact the physiology in the extracellular microenvironment.
LRP1B ligands also include the cellular prion protein (Taylor and Hooper, 2007; Lu et al., 2010).
At the membrane level, LRP1B has been shown to modulate the localization of Urokinase and PDGF receptors (Tanaga et al., 2004) and to retain beta-amyloid precursor protein at the cell surface and reducing amyloid-beta peptide production (Cam et al., 2004).

Intracellular LRP1B partners:
Six interacting partners of the LRP1B cytoplasmic region have been identified by yeast two-hybrid screen and immunoprecipitation. One of the partners, PICK1 recognizes the C-terminus of LRP1B and inhibits phosphorylation of LRP1B by PKC alpha (Shiroshima et al., 2009). The output of these interactions in terms of signaling pathways activated in consequence of LRP1B activity remains unexplored.

Proteolytic release of LRP1B domains:
LRP1B ectodomains resulting from proteolytic shedding of the extracellular region can be found in the soluble form (Dietrich et al., 2010).
LRP1B has also been shown to undergo regulated intra-membrane proteolysis in a gamma-secretase-dependent manner, releasing an intracellular domain (ICD) that then translocates to the nucleus (Liu et al., 2007). The functions of the ICD in the nucleus are unknown.

Functions associated with heterologous ligands:
LRP1B may also act as a receptor for heterologous biomolecules such as the Pseudomonas exotoxin (Pastrana et al., 2005) and, most interestingly, for certain drugs, putting emphasis on the role of endocytosis in cellular drug uptake (Chung and Wasan, 2004). In accordance with this, reduced uptake of liposomes by LRP1B may underlie the mechanism of acquired resistance to liposomal doxorubicin chemotherapy in high-grade serous ovarian cancers that display LRP1B deletion (Cowin et al., 2012).

Homology LRP1B is a member of the LDL receptor family which is composed of seven receptors structurally homologous to the LDL receptor, the prototypic gene of familial hypercholesterolemia (Hobbs et al., 1992). These receptors, commonly known as lipoprotein receptors (LRs), include the LDL receptor, very low density lipoprotein (VLDL) receptor, apoE receptor 2, multiple epidermal growth factor-like domains 7 (MEGF7), glycoprotein 330 (gp330/megalin/LRP2), LRP1 and LRP1B. In addition, the family includes members that are more distantly related, such as LRP5, LRP6 and SorLa/LRP11. The close similarity in protein domain structure between LRPs strongly suggests that Lipoprotein Receptors may share a comparable spectrum of ligands. Nevertheless, this deduction may not be straightforward. For instance, LRP1B ligands of the uPA system were found to overlap those of LRP1, its closest related member (Liu et al., 2001). However, distinct properties are displayed by LRP1B since, in contrast to LRP1, cells expressing LRP1B display a substantially slower rate of uPA/PAI-1 complex internalization (Knisely et al., 2007), which impairs the regeneration of free uPAR on the cell surface and correlates with a diminished rate of cell migration (Liu et al., 2001; Li et al., 2002). This emphasizes that the functions of LRs may be overlapping and yet distinct as a result of their ligand spectrum and kinetics of endocytosis (Liu et al., 2001).

Mutations

Germinal No germline LRP1B mutations have been characterized.
Somatic The LRP1B gene was originally isolated by positional cloning on the basis of homozygous deletions (HD) detected in human lung cancer cell lines (Kohno et al., 2010; Liu et al., 2000a; Liu et al., 2000b). In a genomic-wide screen, LRP1B was reported amongst the top 10 most significantly deleted genes across 3312 human cancer specimens (Beroukhim et al., 2010). Mapping of focal deletions found in these cancer specimens are published at http://www.broadinstitute.org/tumorscape/pages/portalHome.jsf. In individual studies of specific tumor types, LRP1B deletions have been reproducibly been observed in lung (Nagayama et al., 2007; Kohno et al., 2010), esophagus (Sonoda et al., 2004), oral (Cengiz et al., 2007), breast (Kadota et al., 2010), renal (Langbein et al., 2002; Ni et al., 2013), neural (Roversi et al., 2006; Yin et al., 2009), thyroid (Prazeres et al., 2011) and ovarian cancer (Chung and Wasan, 2004).
Aside from deletions, LRP1B point mutations have been reported in a significant percentages of lung cancer (Ding et al., 2008) as well as in the sequencing of genomes derived from melanoma (Nikolaev et al., 2011) and triple negative breast cancer (Craig et al., 2013).

Implicated in

Note
  
Entity Cancer, across types
Note The diversity of biological ligands underlies the role of LRs in multiple pathologic processes, that include atherosclerosis (Tanaga et al., 2004; Seki et al., 2005) Alzheimer's disease (Jaeger and Pietrzik, 2008; Lillis et al., 2008; Wagner and Pietrzik, 2012) and cancer, the focus of this description below.
LRP1B, a member of the low-density lipoprotein (LDL) receptor family, was identified as a putative tumor suppressor. The down-expression of LRP1B was observed in multiple primary cancers.
Oncogenesis The "signature" of LRP1B inactivation is archetypal of a tumor suppressor gene and reflects selection towards bi-allelic inactivation and complete abrogation of the gene function. In tumors, one can observe that multiple inactivation hits, of structural and regulatory nature, have taken place, on both alleles through diverse combinations of events such as genetic deletions (observable by homozygous deletion), accompanied by epigenetic silencing (DNA methylation), or sometimes by microRNA overexpression (Prazeres et al., 2011).
The role of LRP1B as a tumor suppressor may result from modulation of cell migration and invasive capacity, through regulation of the urokinase plasminogen system (Liu et al., 2001). Cells expressing LRP1B display a substantially slower rate of uPA/PAI-1 complex internalization (Knisely et al., 2007) which impairs the regeneration of unoccupied uPAR on the cell surface and correlates with a diminished rate of cell migration (Li et al., 2002; Tanaga et al., 2004). Aside from members of the plasminogen system, LRP1B expression has been shown to deplete the extracellular medium of MMP2 and other factors (Prazeres et al., 2011). These results support the hypothesis that LRP1B endocytosis may (directly or indirectly) constrain the abundance of critical factors in the tumor microenvironment.
  
  
Entity Lung cancer
Note Nagayama, Kohno et al. (2007) have described that homozygous deletions (HD) was searched for in 43 lung cancer cell lines. The gene LRP1B was also included among the genes. Fifty-one homozygous deletions regions containing 113 genes were identified. The LRP1B was the third most frequent targets of HD. All eight HD segments at the LRP1B gene locus detected in that study included its coding exons, consistent with previous reports (Liu et al., 2000a; Sonoda et al., 2004). At present, the pathogenic significance of LRP1B deletions is unclear; however, frequent HD in these loci indicates that the inactivation of this gene has major roles in the development of lung cancer. LRP1B was mapped at the fragile sites, FRA2F, FRA3B, and FRA16D, and had been found homozygously deleted in a subset of lung cancers (Liu et al., 2000a; Zöchbauer-Müller et al., 2000; Paige et al., 2001; Fabbri et al., 2005; Smith et al., 2006).
Kohno, Otsuka et al. (2010) have verified homozygous deletions in 176 genes. They consisted of 171 protein-encoding genes and five miRNA genes. These 176 genes were located in 45 regions on 17 chromosomes. They included known tumor suppressor genes, as well as candidate tumor suppressor genes shown to be hemizygously or homozygously deleted in several types of human cancers, such as LRP1B (Sonoda et al., 2004).
  
  
Entity Esophageal carcinoma
Note The expression of LRP1B mRNA is frequently lost in esophageal squamous cell carcinoma (ESCs) as a consequence of either homozygous deletions or DNA methylation and the re-expression of this gene inhibits growth of ESC cells. These two types of events affecting the LRP1B gene may be useful as novel diagnostic markers for ESC because of their high frequencies, although it remains unclear whether precancerous lesions of this tumor contain either of those alterations. The apparent multiplicity of tumor-suppressing activities of LRP1B, however, suggests that this molecule might be a useful starting point for development of novel therapeutic strategies (Sonoda et al., 2004).
  
  
Entity Oral carcinoma
Note Genome-wide LOH analysis demonstrated high LOH ratio of 2q21-23 region by using the markers D2S1334 and D2S1399 in head and neck cancer (Beder et al., 2003). So far no other study showed frequent LOH of this region in oral cancer, but it has been suggested that at least one tumor suppressor gene exists at 2q21-24 and involves in the carcinogenesis of various cancers including oral carcinoma. One candidate gene could be LRP1B, which has already been proposed to function as a tumor suppressor (Cengiz et al., 2007).
  
  
Entity Breast cancer
Note Kadota, Yang et al. (2010) have observed intragenic deletions within several genes which potentially function as breast cancer tumor suppressor loci. These included deletions which disrupted LRP1B in MCF10CA1h and MCF10CA1a cell lines.
  
  
Entity Renal cancer
Prognosis In urothelial cancer, only 8% of cases with Grade 1 and none with Grade 2 tumors showed loss of heterozygosity at the LRP1B gene, whereas 49% of the Grade 3 cases had allelic loss at the LRP1B genomic region, which can be taken to indicate that alteration of the LRP1B gene region is associated with high grade of urothelial cancer (Langbein et al., 2002).
Oncogenesis Ni, Hu et al. (2013) have investigated the expression of LRP1B in Renal cell cancer (RCC) and its function on cell migration. They found that LRP1B mRNA was widely expressed in the normal renal tubular epithelial cells, but it was frequently down-expressed in RCC tissues and cell lines. The depletion of LRP1B increased the anchorage-independent growth, cell migration and invasion in vitro. Moreover, the expression and activation of Rho family members, actin cytoskeletons and focal adhesions complex (FAC) were also affected, indicating that down-expression of LRP1B led to the increase of cell migration and invasion, which is possibly mediated by actin cytoskeleton remodeling, and expressional alteration of FAC components. At the same time, they also found that silencing of LRP1B obviously occurred in T1 of TNM. The result suggests that silencing of LRP1B is an early event in RCC. Their observation provided an insight into the potential contribution of LRP1B to tumorigenesis, and that LRP1B may be explored as a molecular target in RCC therapy by regulated epigenetic activation means.
These functional specificities in cell spreading, migration and invasion strongly validated that LRP1B may function as a tumor suppressor, and exert opposite effects to LRP1 on cell transformation and malignant progression.
  
  
Entity Glioma
Note Data analysis of full-coverage chromosome 19 highlighted two main regions of copynumber gain, never described before in gliomas, at 19p13.11 and 19q13.13-13.2. Genomic hotspot detection facilitated the identification of small intervals resulting in positional candidate genes such as LRP1B (2q22.3) for losses, and other for gains. These data increase the current knowledge about cryptic genetic changes in gliomas and may facilitate the further identification of novel genetic elements, which may provide us with molecular tools for the improved diagnostics and therapeutic decision-making in these tumors (Roversi et al., 2006).
LRP1B has been found frequently mutated in glioblastoma (GBM) (Roversi et al., 2006). A novel internal deletion of LRP1B was discovered in the U118 GBM cell line and four GBM samples. Nucleotide sequencing of the LRP1B gene from U118 cells showed loss of exons 3 to 18 and an early stop codon, suggesting that the protein was no longer functional. This data suggest that LRP1B acts as a tumor suppressor gene in glioma cells and is aberrant in GBM (Yin et al., 2009).
  
  
Entity Thyroid cancer
Note In non-medullary thyroid cancer, LRP1B under-expression is significantly lower in highly aggressive undifferentiated thyroid tumors (Prazeres et al., 2011). LRP1B expression levels are significantly associated with vascular invasion in follicular thyroid cancer (Prazeres et al., 2011).
Oncogenesis Prazeres, Torres et al. (2011) have shown that LRP1B inactivation (by chromosomal, epigenetic and microRNA (miR)-mediated mechanisms) resulted in changes to the tumor environment that confer cancer cells an increased growth and invasive capacity. Restoration of LRP1B impaired in vitro and in vivo tumor growth, inhibited cell invasion and led to a reduction of matrix metalloproteinase 2 in the extracellular medium. This emphasized the role of an endocytic receptor acting as a tumor suppressor by modulating the extracellular environment composition in a way that constrains the invasive behavior of the cancer cells.
  
  
Entity Ovarian cancer
Prognosis LRP1B binds to fibrinogen and apoE-containing ligands (Haas et al., 2011) and importantly, several studies have suggested that LDL receptor family members are involved in uptake of anionic liposomes and drugs (Chung and Wasan, 2004; Lakkaraju et al., 2002).
Due to high degree of intratumoral heterogeneity and the large number of chemotherapeutic agents commonly used in the relapse setting in high-grade serous cancer (HGSC) patients, the most common subtype of ovarian cancer, it is likely that there will be multiple mechanisms of acquired resistance. It was described that the deletion or downregulation of the lipid transporter LRP1B emerged as a significant correlate of acquired resistance. Functional studies showed that reducing LRP1B expression was sufficient to reduce the sensitivity of HGSC cell lines to liposomal doxorubicin, but not to doxorubicin, whereas LRP1B overexpression was sufficient to increase sensitivity to liposomal doxorubicin. These data indicates that LRP1B loss contributes to the emergence of resistance to chemotherapy, specifically to liposomal doxorubicin (Cowin et al., 2012).
In conclusion, in high-grade serous ovarian cancers, LRP1B deletion is associated with worse prognosis as a result of acquired chemotherapy resistance to liposomal doxorubicin (Cowin et al., 2012).
  
  
Entity Alzheimer's disease
Note Initially, LDL receptor gene family was of high interest due to its key function in cholesterol/apolipoprotein E (ApoE) uptake, with the e4 allele of ApoE as the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
In a review, Jaeger and Pietrzik (2008) have highlighted the involvement of different lipoprotein receptors in AD. Their functional implications reach from mediating amyloid precursor protein (APP) internalization, as LRP1B, intracellular trafficking, Aβ clearance out of the brain (LRP1) to an involvement in ApoE/cholesterol metabolism. These findings implicate an important role for lipoprotein receptors in the underlying mechanisms leading to the development of AD. These mechanisms will give way to new therapeutic strategies for the treatment of neurodegenerative diseases via interference with the role of lipoprotein receptors.
  
  
Entity Atherosclerosis
Note Seki, Bujo et al. (2005) have characterized the functions of three groups of cultured smooth muscle cells (SMCs) with different origins in atherosclerotic arteries, in order to know a functional significance of LRP1B in the increased migration of SMCs. The results strongly suggest that LRP1B plays a role in the regulation of migration activity of SMCs through the modification of PDGF signals in the process of atherosclerosis.
Tanaga, Bujo et al. (2004) have described that LRP1B modulates the catabolism of uPAR and PDGFR, affecting the migration of smooth muscle cells (SMCs). This functional characterization of LRP1B opens novel avenues for elucidating the (patho)physiological significance of SMC migration in atheromatous plaques.
  

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Alteration of the LRP1B gene region is associated with high grade of urothelial cancer.
Langbein S, Szakacs O, Wilhelm M, Sukosd F, Weber S, Jauch A, Lopez Beltran A, Alken P, Kalble T, Kovacs G.
Lab Invest. 2002 May;82(5):639-43.
PMID 12004004
 
Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.
Li Y, Knisely JM, Lu W, McCormick LM, Wang J, Henkin J, Schwartz AL, Bu G.
J Biol Chem. 2002 Nov 1;277(44):42366-71. Epub 2002 Aug 22.
PMID 12194987
 
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK.
Physiol Rev. 2008 Jul;88(3):887-918. doi: 10.1152/physrev.00033.2007. (REVIEW)
PMID 18626063
 
The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.
Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G.
J Biol Chem. 2001 Aug 3;276(31):28889-96. Epub 2001 May 30.
PMID 11384978
 
Genomic organization of a new candidate tumor suppressor gene, LRP1B.
Liu CX, Musco S, Lisitsina NM, Yaklichkin SY, Lisitsyn NA.
Genomics. 2000b Oct 15;69(2):271-4.
PMID 11031110
 
gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells.
Liu CX, Ranganathan S, Robinson S, Strickland DK.
J Biol Chem. 2007 Mar 9;282(10):7504-11. Epub 2007 Jan 16.
PMID 17227771
 
Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ.
Biochem Biophys Res Commun. 2009 Jan 16;378(3):433-8. doi: 10.1016/j.bbrc.2008.11.050. Epub 2008 Nov 24.
PMID 19028452
 
Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer.
Lu YJ, Wu CS, Li HP, Liu HP, Lu CY, Leu YW, Wang CS, Chen LC, Lin KH, Chang YS.
Genes Chromosomes Cancer. 2010 May;49(5):412-24. doi: 10.1002/gcc.20752.
PMID 20095042
 
The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions.
May P, Woldt E, Matz RL, Boucher P.
Ann Med. 2007;39(3):219-28. (REVIEW)
PMID 17457719
 
Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution.
Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J.
Genes Chromosomes Cancer. 2007 Nov;46(11):1000-10.
PMID 17674361
 
Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma.
Nakagawa T, Pimkhaokham A, Suzuki E, Omura K, Inazawa J, Imoto I.
Cancer Sci. 2006 Oct;97(10):1070-4.
PMID 16918994
 
Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer.
Ni S, Hu J, Duan Y, Shi S, Li R, Wu H, Qu Y, Li Y.
Cancer Sci. 2013 Jul;104(7):817-25. doi: 10.1111/cas.12157. Epub 2013 May 16.
PMID 23521319
 
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.
Nikolaev SI, Rimoldi D, Iseli C, Valsesia A, Robyr D, Gehrig C, Harshman K, Guipponi M, Bukach O, Zoete V, Michielin O, Muehlethaler K, Speiser D, Beckmann JS, Xenarios I, Halazonetis TD, Jongeneel CV, Stevenson BJ, Antonarakis SE.
Nat Genet. 2011 Dec 25;44(2):133-9. doi: 10.1038/ng.1026.
PMID 22197931
 
Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
Nykjaer A, Petersen CM, Moller B, Jensen PH, Moestrup SK, Holtet TL, Etzerodt M, Thogersen HC, Munch M, Andreasen PA, et al.
J Biol Chem. 1992 Jul 25;267(21):14543-6.
PMID 1378833
 
LRP 1 B functions as a receptor for Pseudomonas exotoxin.
Pastrana DV, Hanson AJ, Knisely J, Bu G, Fitzgerald DJ.
Biochim Biophys Acta. 2005 Sep 25;1741(3):234-9.
PMID 16095885
 
Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells.
Prazeres H, Torres J, Rodrigues F, Pinto M, Pastoriza MC, Gomes D, Cameselle-Teijeiro J, Vidal A, Martins TC, Sobrinho-Simoes M, Soares P.
Oncogene. 2011 Mar 17;30(11):1302-17. doi: 10.1038/onc.2010.512. Epub 2010 Nov 8.
PMID 21057533
 
Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior.
Rahmatpanah FB, Carstens S, Guo J, Sjahputera O, Taylor KH, Duff D, Shi H, Davis JW, Hooshmand SI, Chitma-Matsiga R, Caldwell CW.
Leukemia. 2006 Oct;20(10):1855-62. Epub 2006 Aug 10.
PMID 16900213
 
Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines.
Roversi G, Pfundt R, Moroni RF, Magnani I, van Reijmersdal S, Pollo B, Straatman H, Larizza L, Schoenmakers EF.
Oncogene. 2006 Mar 9;25(10):1571-83.
PMID 16247447
 
LRP1B is a negative modulator of increased migration activity of intimal smooth muscle cells from rabbit aortic plaques.
Seki N, Bujo H, Jiang M, Tanaga K, Takahashi K, Yagui K, Hashimoto N, Schneider WJ, Saito Y.
Biochem Biophys Res Commun. 2005 Jun 17;331(4):964-70.
PMID 15882972
 
Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1.
Shiroshima T, Oka C, Kawaichi M.
FEBS Lett. 2009 Jan 5;583(1):43-8. doi: 10.1016/j.febslet.2008.11.045. Epub 2008 Dec 9.
PMID 19071120
 
Common fragile sites, extremely large genes, neural development and cancer.
Smith DI, Zhu Y, McAvoy S, Kuhn R.
Cancer Lett. 2006 Jan 28;232(1):48-57. Epub 2005 Oct 10. (REVIEW)
PMID 16221525
 
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Gray JW, Hirohashi S, Inazawa J.
Cancer Res. 2004 Jun 1;64(11):3741-7.
PMID 15172977
 
LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors.
Tanaga K, Bujo H, Zhu Y, Kanaki T, Hirayama S, Takahashi K, Inoue M, Mikami K, Schneider WJ, Saito Y.
Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1422-8. Epub 2004 May 27.
PMID 15166012
 
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein.
Taylor DR, Hooper NM.
Biochem J. 2007 Feb 15;402(1):17-23.
PMID 17155929
 
Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.
Taylor KH, Kramer RS, Davis JW, Guo J, Duff DJ, Xu D, Caldwell CW, Shi H.
Cancer Res. 2007a Sep 15;67(18):8511-8.
PMID 17875690
 
Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia.
Taylor KH, Pena-Hernandez KE, Davis JW, Arthur GL, Duff DJ, Shi H, Rahmatpanah FB, Sjahputera O, Caldwell CW.
Cancer Res. 2007b Mar 15;67(6):2617-25.
PMID 17363581
 
The role of lipoprotein receptors on the physiological function of APP.
Wagner T, Pietrzik CU.
Exp Brain Res. 2012 Apr;217(3-4):377-87. doi: 10.1007/s00221-011-2876-8. Epub 2011 Sep 23. (REVIEW)
PMID 21947084
 
Lipoprotein receptors: new roles for ancient proteins.
Willnow TE, Nykjaer A, Herz J.
Nat Cell Biol. 1999 Oct;1(6):E157-62. (REVIEW)
PMID 10559979
 
High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray.
Yin D, Ogawa S, Kawamata N, Tunici P, Finocchiaro G, Eoli M, Ruckert C, Huynh T, Liu G, Kato M, Sanada M, Jauch A, Dugas M, Black KL, Koeffler HP.
Mol Cancer Res. 2009 May;7(5):665-77. doi: 10.1158/1541-7786.MCR-08-0270. Epub 2009 May 12.
PMID 19435819
 
Fragile histidine triad (FHIT) gene abnormalities in lung cancer.
Zochbauer-Muller S, Wistuba II, Minna JD, Gazdar AF.
Clin Lung Cancer. 2000 Nov;2(2):141-5.
PMID 14731325
 

Citation

This paper should be referenced as such :
Prazeres, H ; Salgado, C ; Duarte, C ; Soares, P
LRP1B (low density lipoprotein receptor-related protein 1B)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(2):93-101.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/LRP1BID41200ch2q22.html

External links

Nomenclature
HGNC (Hugo)LRP1B   6693
Cards
AtlasLRP1BID41200ch2q22
Entrez_Gene (NCBI)LRP1B  53353  LDL receptor related protein 1B
AliasesLRP-1B; LRP-DIT; LRPDIT
GeneCards (Weizmann)LRP1B
Ensembl hg19 (Hinxton)ENSG00000168702 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168702 [Gene_View]  chr2:140231427-142131701 [Contig_View]  LRP1B [Vega]
ICGC DataPortalENSG00000168702
TCGA cBioPortalLRP1B
AceView (NCBI)LRP1B
Genatlas (Paris)LRP1B
WikiGenes53353
SOURCE (Princeton)LRP1B
Genetics Home Reference (NIH)LRP1B
Genomic and cartography
GoldenPath hg38 (UCSC)LRP1B  -     chr2:140231427-142131701 -  2q22.1-q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRP1B  -     2q22.1-q22.2   [Description]    (hg19-Feb_2009)
EnsemblLRP1B - 2q22.1-q22.2 [CytoView hg19]  LRP1B - 2q22.1-q22.2 [CytoView hg38]
Mapping of homologs : NCBILRP1B [Mapview hg19]  LRP1B [Mapview hg38]
OMIM608766   
Gene and transcription
Genbank (Entrez)AB209707 AF176832 AK054663
RefSeq transcript (Entrez)NM_018557
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRP1B
Cluster EST : UnigeneHs.656461 [ NCBI ]
CGAP (NCI)Hs.656461
Alternative Splicing GalleryENSG00000168702
Gene ExpressionLRP1B [ NCBI-GEO ]   LRP1B [ EBI - ARRAY_EXPRESS ]   LRP1B [ SEEK ]   LRP1B [ MEM ]
Gene Expression Viewer (FireBrowse)LRP1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53353
GTEX Portal (Tissue expression)LRP1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZR2
Splice isoforms : SwissVarQ9NZR2
PhosPhoSitePlusQ9NZR2
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LDLRB (PS51120)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    cEGF    DUF5050    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    LDLR_class-A_CS    LDLR_classB_rpt    LDrepeatLR_classA_rpt   
Domain families : Pfam (Sanger)cEGF (PF12662)    DUF5050 (PF16472)    EGF (PF00008)    EGF_CA (PF07645)    Ldl_recept_a (PF00057)    Ldl_recept_b (PF00058)   
Domain families : Pfam (NCBI)pfam12662    pfam16472    pfam00008    pfam07645    pfam00057    pfam00058   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LDLa (SM00192)  LY (SM00135)  
Conserved Domain (NCBI)LRP1B
DMDM Disease mutations53353
Blocks (Seattle)LRP1B
SuperfamilyQ9NZR2
Human Protein AtlasENSG00000168702
Peptide AtlasQ9NZR2
HPRD16383
IPIIPI00917576   IPI00917696   IPI00032063   IPI00916848   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZR2
IntAct (EBI)Q9NZR2
FunCoupENSG00000168702
BioGRIDLRP1B
STRING (EMBL)LRP1B
ZODIACLRP1B
Ontologies - Pathways
QuickGOQ9NZR2
Ontology : AmiGOcalcium ion binding  receptor-mediated endocytosis  protein transport  integral component of membrane  receptor complex  
Ontology : EGO-EBIcalcium ion binding  receptor-mediated endocytosis  protein transport  integral component of membrane  receptor complex  
NDEx NetworkLRP1B
Atlas of Cancer Signalling NetworkLRP1B
Wikipedia pathwaysLRP1B
Orthology - Evolution
OrthoDB53353
GeneTree (enSembl)ENSG00000168702
Phylogenetic Trees/Animal Genes : TreeFamLRP1B
HOVERGENQ9NZR2
HOGENOMQ9NZR2
Homologs : HomoloGeneLRP1B
Homology/Alignments : Family Browser (UCSC)LRP1B
Gene fusions - Rearrangements
Fusion : MitelmanLRP1B/GULP1 [2q22.1/2q32.1]  
Fusion : MitelmanLRP1B/HECW2 [2q22.1/2q32.3]  [t(2;2)(q22;q33)]  
Fusion : MitelmanTXNL1/LRP1B [18q21.31/2q22.1]  [t(2;18)(q22;q21)]  
Fusion: TCGALRP1B 2q22.1 HECW2 2q32.3 LUSC
Fusion: TCGATXNL1 18q21.31 LRP1B 2q22.1 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRP1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRP1B
dbVarLRP1B
ClinVarLRP1B
1000_GenomesLRP1B 
Exome Variant ServerLRP1B
ExAC (Exome Aggregation Consortium)LRP1B (select the gene name)
Genetic variants : HAPMAP53353
Genomic Variants (DGV)LRP1B [DGVbeta]
DECIPHERLRP1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRP1B 
Mutations
ICGC Data PortalLRP1B 
TCGA Data PortalLRP1B 
Broad Tumor PortalLRP1B
OASIS PortalLRP1B [ Somatic mutations - Copy number]
Cancer Gene: CensusLRP1B 
Somatic Mutations in Cancer : COSMICLRP1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRP1B
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LRP1B
DgiDB (Drug Gene Interaction Database)LRP1B
DoCM (Curated mutations)LRP1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRP1B (select a term)
intoGenLRP1B
NCG5 (London)LRP1B
Cancer3DLRP1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608766   
Orphanet
MedgenLRP1B
Genetic Testing Registry LRP1B
NextProtQ9NZR2 [Medical]
TSGene53353
GENETestsLRP1B
Target ValidationLRP1B
Huge Navigator LRP1B [HugePedia]
snp3D : Map Gene to Disease53353
BioCentury BCIQLRP1B
ClinGenLRP1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53353
Chemical/Pharm GKB GenePA30451
Clinical trialLRP1B
Miscellaneous
canSAR (ICR)LRP1B (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRP1B
EVEXLRP1B
GoPubMedLRP1B
iHOPLRP1B
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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