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SOCS2 (suppressor of cytokine signaling 2)

Written2015-08Indranil Paul, Leandro Fernández-Pérez, Amilcar Flores-Morales
Institut for Veteriaer Sygdomsbiologi, Danish Cancer Society Research Center, University of Copenhagen, Denmark (IP, AFM); University of Las Palmas de GC, Faculty of Health Sciences, Molecular and Translational Endocrinology Group, c/ Dr. Pasteur s/n - Campus San Cristobal, 35016 - Las Palmas, Spain, (LFP)
This article is an update of :
2007-10Leandro Fernández-Pérez, Amilcar Flores-Morales
University of Las Palmas de GC, Faculty of Health Sciences, Molecular and Translational Endocrinology Group, c/ Dr. Pasteur s/n - Campus San Cristobal, 35016 - Las Palmas, Spain, (LFP); Department of Molecular Medicine and Surgery, Karolinska Institute, 17176 Stockholm, Sweden (AFM)

Abstract Review on SOCS2, with data on DNA, on the protein encoded, and where the gene is implicated.

Keywords SOCS2; proteasome; immune cell differentiation; neuronal development; inflammation; cancer; diabetes

(Note : for Links provided by Atlas : click)


Alias (NCBI)CIS-2, Cytokine-inducible SH2 protein 2
CIS2, STAT induced STAT inhibitor-2
Cish2, STAT-induced STAT inhibitor 2
SOCS-2, suppressor of cytokine signaling 2
SSI-2, suppressor of cytokine signaling-2
HGNC Alias symbSTATI2
HGNC Alias nameSTAT-induced STAT inhibitor-2
LocusID (NCBI) 8835
Atlas_Id 44123
Location 12q21.3-q23 (Yandava et al., 1999). Plus strand.  [Link to chromosome band 12q21]
Location_base_pair Starts at 93569969 and ends at 93576745 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping SOCS2.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM116 (12q24.13) / SOCS2 (12q22)WTAP (6q25.3) / SOCS2 (12q22)


Description NCBI Reference Sequence: NC_000012.12; Coding positions from 93,966,674 to 93,968,952 (length: 2,279 bp). Mouse SOCS2 gene is composed of 3 exons and 2 introns (Metcalf et al., 2000). Human SOCS-2 comprises 3 exons spanning approximately 6,38 kb of genomic DNA.
Transcription 2888 bp mRNA. There are 6 transcript variants. Transcript variant 5 is the largest and is cited here. The variants differ in their 5' UTR. All variants encode the same protein.


  Diagram representing the structure of SOCS proteins. At least eight proteins belonging to the SOCS family of proteins are shown (upper panel). They are characterized by the presence of an SH2 central domain and the SOCS box domain at the C-terminus. A small domain called kinase inhibitory region (KIR), only found in SOCS1 and SOCS3, is shown as a small box at the N-terminal region. SOCS proteins can interact with phosphotyrosine phosphorylated proteins through their SH2 domain and with Elongin BC through their SOCS box domain. Other proteins containing a SOCS box domain but lacking a SH2 domain are also shown (lower panel). Adapted from Elliot and Johnston (Elliott and Johnston, 2004) with modifications.
Description Reference sequence for SOCS2 protein: NP_001257399.1. SOCS2 contains 198 amino acid residues with a molecular weight of 22172 Da.
SOCS2 belongs to the SOCS box family. SOCS2 contains a C terminal SOCS box (residue 151-197) for ElonginB,C/Cullin5/Rbx2 interaction. The unstructured N-terminal region (residue 1-47) and the SH2 domain (residue 48-156) is implicated in substrate interaction. The SH2 domain is known to interact with conserved phosphotyrosine residues on target proteins imparting substrate specificity to SOCS box proteins.
Expression SOCS mRNA and protein levels are constitutively low in unstimulated cells, but their expression is rapidly induced upon cytokine stimulation, thereby creating a negative feedback loop. Although constitutively expressed SOCS2 mRNA has been detected in several tissues and cell types, its expression is, in general, induced by stimulation with different cytokines and hormones (Rico-Bautista et al., 2006). SOCS2 promoter analysis indicates the presence of AhR and STAT5 binding sites that confer responsiveness to dioxin (Boverhof et al., 2004) and GH (Vidal et al., 2006), respectively.
Localisation Intracellular, cytoplasm. SOCS2 can be located in the nuclear compartment when overexpressed in cell cultures.
Function The function of SOCS proteins rely, on one hand, in their ability to bind tyrosine phosphorylated proteins through their SH2 domains and, on the other hand, to bind Elongins B/C through their SOCS box domains which in turn engages with the Cullin5/Rbx2 complex to assemble an E3 ubiquitin ligase. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction (Rico-Bautista et al., 2006). Being a substrate recognition module for Cullin5/Rbx2 E3 ligase complex, SOCS2 is involved in regulating protein turnover by targeting proteins for proteasome-mediated degradation. SOCS2 binds and promote the ubiquitination of the Growth Hormone receptor (GHR) controlling GHR content in different tissues (Metcalf et al., 2000; Vesterlund et al., 2011). Through the negative regulation of GHR signaling, SOCS2 exerts multiple actions in growth and metabolisms (Greenhalgh et al., 2005; Zadjali et al., 2012). SOCS2 is also a critical regulator of inflammatory responses and immune cell differentiation (Machado et al., 2006; Hu et al., 2009a). Recently, SOCS2 is being implicated in the progression of multiple human cancers (Schultheis et al., 2002; Harris et al., 2006; Newton et al., 2010; Iglesias-Gato et al., 2014).
Homology HomoloGene (NCBI) Genes identified as putative homologs: NP_003868.1 SOCS2, H.sapiens; XP_001139989.1 SOCS2, P.troglodytes; XP_002798772.1 SOCS2, M.mulatta; XP_005629280.1 SOCS2, C.lupus; NP_803489.1 SOCS2, B.taurus; NP_001162126.1 Socs2, M.musculus; NP_478115.1 Socs2, R.norvegicus; NP_989871.1 SOCS2, G.gallus; NP_001120898.1 socs2, X.tropicalis; NP_001108022.1 socs2, D.rerio


Note There are 8 SNPs in coding regions of human SOCS2 which result in missense protein residues (NCBI dbSNP). Homozygous null mice display gigantism (Metcalf et al., 2000), impaired innate immune cell differentiation and hypersensitivity to infections (Baetz et al., 2004; Yoshimura et al., 2005; Yoshimura et al., 2007). Homozygous null mice also display altered metabolic and inflammatory response to high fat feeding (Zadjali et al., 2012;). SNP: increasing the risk of type 2 diabetes (Kato et al., 2006)

Implicated in

Entity Neural development
Note SOCS2 plays a critical role in neuronal development, growth, and stem cell differentiation (Turnley et al., 2002).
Entity Inflammation
Note SOCS2 deficient dendritic cells and macrophages are hyper-responsive to microbial stimulation. SOCS2 deficient animals have uncontrolled production of inflammatory cytokines (IL-12, IFNγand TNFα ) and succumb to endotoxic shock, polymicrobial sepsis and other microbial infections (Esper et al., 2012). SOCS2 plays a central role in differentiation and maturation of innate immune cells. Specifically, SOCS2 promotes generation of regulatory dendritic cells and macrophages (Novak et al., 1999; Jackson et al., 2004; Hu et al., 2012) and Treg population (Knosp et al., 2013). Conversely, SOCS2 inhibits Th2 differentiation (Knosp et al., 2011). Upon induced inflammatory challenge, absence of SOCS2 has been shown to render multiple immune cell types incapable of mounting anti-inflammatory responses. Under resting conditions, SOCS2 null animals also display a population-bias towards a pro-inflammatory phenotype (Machado et al., 2006; Lee et al., 2010; Knosp et al., 2011; Posselt et al., 2011; Hu et al., 2012).
SOCS2 is known to inhibit TGFβ, IL-4, IL-5, IL-10, IL-13 and IFNγ signaling (Knosp et al., 2011, Knosp et al., 2013). In general, SOCS2 inhibits expression/secretion of pro-inflammatory cytokines and promotes generation of regulatory phenotype (anti-inflammatory) of immune cells. SOCS2 is thought to function in both MyD88 dependent and independent TLR4 signaling pathways because its downregulation negatively affects SAPK/JNK, p38 MAPK, ERK and NFkB signaling (Hu et al., 2009b). Being an E3 ligase, SOCS2 regulates a number of proteins highly implicated in regulation of immune responses such as FoxP3 (Knosp et al., 2013) and TRAF6 (McBerry et al., 2012). SOCS2 also accelerates degradation of other members of the SOCS family such as SOCS1 and SOCS3 thus further impinging on downstream STAT signaling (Piessevaux et al., 2006; Tannahill et al., 2005). In turn, SOCS2 gene itself is under regulation of various inflammatory signals (e.g., LPS, dioxins, LipoxinA4) (Machado et al., 2006; Hu et al., 2009b, 2012) and cytokines (e.g.,IL-4, IL-10, IFNβ, IFNγ) (Knosp et al., 2011; Posselt et al., 2011).
Entity Breast cancer
Note SOCS2 expression inversely correlates with histological grades and is a positive prognostic factor (Farabegoli et al., 2005; Haffner et al., 2007). SOCS2 expression is induced by estrogen receptor (ER) activity. Estrogen treatment activates ER which in turn upregulates miR-191 which through downregulation of SATB1, a global chromatic remodeller, enhances SOCS2 transcription (Nagpal et al., 2013). Upregulation of SOCS2 upon estrogen administration antagonizes growth hormone action mediated through JAK2/STAT3 and STAT5 (Leung et al., 2003).
Entity Colon cancer
Note Both heterozygous and homozygous deletions of SOCS2 promoted spontaneous tumorigenesis in ApcMin/+ mice model of colorectal cancer. This is accompanied with a dramatic increase in AP-1 DNA binding (Newton et al., 2010). Acromegalic patients are prone to colonic polyp formation. These patients with hyperplastic polyps have increased SOCS2 transcripts (Bogazzi et al., 2009).
Entity Myeloproliferative disorder
Note SOCS2 gene is also hypermethylated in myeloproliferative disorders (Zhou et al., 2009; Zhang et al., 2013). SOCS2 is an important negative regulator of a constitutive active mutant of JAK2 (JAK2 V617F) (Etienne et al., 2007).
Entity Prostate cancer
Note SOCS2 is upregulated at both mRNA and protein levels in primary prostate cancer tissues relative to normal prostate. This upregulation is correlated to lower Gleason score, absence of metastasis and low PSA failure (Zhu et al., 2013). In contrast, SOCS2 expression is downregulated in castration resistant prostate cancer. This is partly explained by the fact that SOCS2 is transcriptionally upregulated by androgen receptor and inhibits GH signaling in prostate (Iglesias-Gato et al., 2014).
Entity Other cancers
Note SOCS2 gene is hypermethylated in melanoma and ovarian carcinoma (Marini et al., 2006; Liu et al., 2008). Lower SOCS2 expressions are also correlated to higher grades of hepatocellular carcinoma (Qiu et al., 2013).
Entity Gigantism
Note SOCS2 null mice are giants but not obese (Metcalf et al., 2000). SOCS2 deficient mice have growth and metabolic characteristics that can be related to the enhanced GH actions (Rico-Bautista et al., 2005). On the other hand, the gigantic phenotype displayed by SOCS2 null mice is mechanistically different from that of human acromegalic patients as they do not exhibit increased circulating IGF-1 levels and seems to express reduced levels of GH (Greenhalgh 2005 and Zadjali 2012).
Disease Gigantism is a condition characterized by excessive growth, significantly above average. This is caused due to an overactivation of growth hormone signaling.
Entity Diabetes
Note Genomic linkage analysis identified SOCS2 as a susceptibility gene for type 2 diabetes in a cohort of Japanese individuals. In the same study, adenovirus-mediated expression of the SOCS2 gene in MIN6 cells or isolated rat islets significantly suppressed glucose-stimulated insulin secretion (Kato et al., 2006). Constitutive SOCS2 expression in mice pancreatic beta cells interferes with proinsulin processing and leads to decreased insulin secretion (Lebrun et al., 2010). In contrast, SOCS2 null mice does not exhibit obvious defects in pancreatic beta cell function. When challenged with high fat diet SOCS2 null mice are protected from hepatic steatosis but exhibit an exacerbated inflammatory response and a worsening of insulin sensitivity as compared to wild-type mice on a similar diet.
Disease Diabetes is a condition characterized by high blood sugar levels. This is caused due to inadequate insulin production or insulin resistance.
Entity Osteoarthritis
Note Analysis of SOCS2 null mice has revealed that the absence of SOCS2 induces a reduction in the trabecular and cortical volumetric bone mineral density (Lorentzon et al., 2005). SOCS2 induces the differentiation of C2C12 mesenchymal cells into myoblasts or osteoblasts (Ouyang et al., 2006).
Disease Osteoarthritis is a condition characterized by mechanical degeneration of joints resulting in pain and restricted movement. This is caused due to hereditary and metabolic reasons.


Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells
Baetz A, Frey M, Heeg K, Dalpke AH
J Biol Chem 2004 Dec 24;279(52):54708-15
PMID 15491991
Changes in the expression of suppressor of cytokine signalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps
Bogazzi F, Ultimieri F, Raggi F, Russo D, Costa A, Marciano E, Bartalena L, Martino E
Clin Endocrinol (Oxf) 2009 Jun;70(6):898-906
PMID 18844680
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells
Boverhof DR, Tam E, Harney AS, Crawford RB, Kaminski NE, Zacharewski TR
Mol Pharmacol 2004 Dec;66(6):1662-70
PMID 15371557
SOCS: role in inflammation, allergy and homeostasis
Elliott J, Johnston JA
Trends Immunol 2004 Aug;25(8):434-40
PMID 15275643
Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease
Esper L, Roman-Campos D, Lara A, Brant F, Castro LL, Barroso A, Araujo RR, Vieira LQ, Mukherjee S, Gomes ER, Rocha NN, Ramos IP, Lisanti MP, Campos CF, Arantes RM, Guatimosim S, Weiss LM, Cruz JS, Tanowitz HB, Teixeira MM, Machado FS
Am J Pathol 2012 Jul;181(1):130-40
PMID 22658486
Rearrangements involving 12q in myeloproliferative disorders: possible role of HMGA2 and SOCS2 genes
Etienne A, Carbuccia N, Adélaïde J, Bekhouche I, Rémy V, Sohn C, Sainty D, Gastaut JA, Olschwang S, Birnbaum D, Mozziconacci MJ, Chaffanet M
Cancer Genet Cytogenet 2007 Jul 1;176(1):80-8
PMID 17574970
Suppressor of cytokine signalling 2 (SOCS-2) expression in breast carcinoma
Farabegoli F, Ceccarelli C, Santini D, Taffurelli M
J Clin Pathol 2005 Oct;58(10):1046-50
PMID 16189149
SOCS2 negatively regulates growth hormone action in vitro and in vivo
Greenhalgh CJ, Rico-Bautista E, Lorentzon M, Thaus AL, Morgan PO, Willson TA, Zervoudakis P, Metcalf D, Street I, Nicola NA, Nash AD, Fabri LJ, Norstedt G, Ohlsson C, Flores-Morales A, Alexander WS, Hilton DJ
J Clin Invest 2005 Feb;115(2):397-406
PMID 15690087
Favorable prognostic value of SOCS2 and IGF-I in breast cancer
Haffner MC, Petridou B, Peyrat JP, Révillion F, Müller-Holzner E, Daxenbichler G, Marth C, Doppler W
BMC Cancer 2007 Jul 25;7:136
PMID 17651480
Socs2 and elf5 mediate prolactin-induced mammary gland development
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Mol Endocrinol 2006 May;20(5):1177-87
PMID 16469767
LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop
Hu J, Lou D, Carow B, Winerdal ME, Rottenberg M, Wikström AC, Norstedt G, Winqvist O
PLoS One 2012;7(1):e30166
PMID 22291912
SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation
Hu J, Winqvist O, Flores-Morales A, Wikström AC, Norstedt G
PLoS One 2009 Sep 25;4(9):e7178
PMID 19779605
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer
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Carcinogenesis 2014 Jan;35(1):24-33
PMID 24031028
Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling
Jackson SH, Yu CR, Mahdi RM, Ebong S, Egwuagu CE
J Immunol 2004 Feb 15;172(4):2307-15
PMID 14764699
Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese
Kato H, Nomura K, Osabe D, Shinohara S, Mizumori O, Katashima R, Iwasaki S, Nishimura K, Yoshino M, Kobori M, Ichiishi E, Nakamura N, Yoshikawa T, Tanahashi T, Keshavarz P, Kunika K, Moritani M, Kudo E, Tsugawa K, Takata Y, Hamada D, Yasui N, Miyamoto T, Shiota H, Inoue H, Itakura M
Genomics 2006 Apr;87(4):446-58
PMID 16406727
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses
Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA
J Exp Med 2011 Jul 4;208(7):1523-31
PMID 21646394
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2
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J Immunol 2013 Apr 1;190(7):3235-45
PMID 23455506
The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion
Lebrun P, Cognard E, Gontard P, Bellon-Paul R, Filloux C, Berthault MF, Magnan C, Ruberte J, Luppo M, Pujol A, Pachera N, Herchuelz A, Bosch F, Van Obberghen E
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PMID 20499047
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2
Lee SH, Yun S, Piao ZH, Jeong M, Kim DO, Jung H, Lee J, Kim MJ, Kim MS, Chung JW, Kim TD, Yoon SR, Greenberg PD, Choi I
J Immunol 2010 Jul 15;185(2):917-28
PMID 20543098
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
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Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1016-21
PMID 12552091
Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
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Pigment Cell Melanoma Res 2008 Oct;21(5):545-58
PMID 18627528
Reduced bone mineral density in SOCS-2-deficient mice
Lorentzon M, Greenhalgh CJ, Mohan S, Alexander WS, Ohlsson C
Pediatr Res 2005 Feb;57(2):223-6
PMID 15585682
Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J
Nat Med 2006 Mar;12(3):330-4
PMID 16415877
Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma
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J Invest Dermatol 2006 Feb;126(2):422-31
PMID 16374457
SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses
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PLoS One 2012;7(6):e38384
PMID 22693634
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Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, Nicola NA, Hilton DJ, Alexander WS
Nature 2000 Jun 29;405(6790):1069-73
PMID 10890450
MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer
Nagpal N, Ahmad HM, Molparia B, Kulshreshtha R
Carcinogenesis 2013 Aug;34(8):1889-99
PMID 23542418
Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation
Newton VA, Ramocki NM, Scull BP, Simmons JG, McNaughton K, Lund PK
Am J Pathol 2010 May;176(5):2320-32
PMID 20348236
Differential ability of SOCS proteins to regulate IL-6 and CSF-1 induced macrophage differentiation
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Growth Factors 1999;16(4):305-14
PMID 10427504
SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
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J Cell Physiol 2006 May;207(2):428-36
PMID 16419040
Functional cross-modulation between SOCS proteins can stimulate cytokine signaling
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J Biol Chem 2006 Nov 3;281(44):32953-66
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Suppressor of cytokine signaling 2 is a feedback inhibitor of TLR-induced activation in human monocyte-derived dendritic cells
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J Immunol 2011 Sep 15;187(6):2875-84
PMID 21844389
Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis
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Mol Cell Biochem 2013 Jun;378(1-2):99-106
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This paper should be referenced as such :
Indranil Paul, Leandro Fernandez-Prez, Amilcar Flores-Morales
SOCS2 (suppressor of cytokine signaling 2)
Atlas Genet Cytogenet Oncol Haematol. ;(6):341-346.
Free journal version : [ pdf ]   [ DOI ]
History of this paper:
Fernandez-Pérez, L ; Flores-Morales, A. SOCS2 (suppressor of cytokine signaling 2). Atlas Genet Cytogenet Oncol Haematol. 2008;12(3):240-242.

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;12)(q25;q22) WTAP/SOCS2

External links

HGNC (Hugo)SOCS2   19382
Entrez_Gene (NCBI)SOCS2    suppressor of cytokine signaling 2
AliasesCIS2; Cish2; SOCS-2; SSI-2; 
GeneCards (Weizmann)SOCS2
Ensembl hg19 (Hinxton)ENSG00000120833 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120833 [Gene_View]  ENSG00000120833 [Sequence]  chr12:93569969-93576745 [Contig_View]  SOCS2 [Vega]
ICGC DataPortalENSG00000120833
TCGA cBioPortalSOCS2
Genatlas (Paris)SOCS2
SOURCE (Princeton)SOCS2
Genetics Home Reference (NIH)SOCS2
Genomic and cartography
GoldenPath hg38 (UCSC)SOCS2  -     chr12:93569969-93576745 +  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOCS2  -     12q22   [Description]    (hg19-Feb_2009)
GoldenPathSOCS2 - 12q22 [CytoView hg19]  SOCS2 - 12q22 [CytoView hg38]
genome Data Viewer NCBISOCS2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB004903 AB006966 AB451318 AF020590 AF037989
RefSeq transcript (Entrez)NM_001270467 NM_001270468 NM_001270469 NM_001270470 NM_001270471 NM_003877
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOCS2
Alternative Splicing GalleryENSG00000120833
Gene ExpressionSOCS2 [ NCBI-GEO ]   SOCS2 [ EBI - ARRAY_EXPRESS ]   SOCS2 [ SEEK ]   SOCS2 [ MEM ]
Gene Expression Viewer (FireBrowse)SOCS2 [ Firebrowse - Broad ]
GenevisibleExpression of SOCS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8835
GTEX Portal (Tissue expression)SOCS2
Human Protein AtlasENSG00000120833-SOCS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14508   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14508  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14508
Splice isoforms : SwissVarO14508
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SOCS (PS50225)   
Domains : Interpro (EBI)SH2    SH2_dom_sf    SOCS2    SOCS2_SH2    SOCS_box    SOCS_box-like_dom_sf   
Domain families : Pfam (Sanger)SH2 (PF00017)    SOCS_box (PF07525)   
Domain families : Pfam (NCBI)pfam00017    pfam07525   
Domain families : Smart (EMBL)SH2 (SM00252)  SOCS (SM00253)  SOCS_box (SM00969)  
Conserved Domain (NCBI)SOCS2
Blocks (Seattle)SOCS2
PDB (RSDB)2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
PDB Europe2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
PDB (PDBSum)2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
PDB (IMB)2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
Structural Biology KnowledgeBase2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
SCOP (Structural Classification of Proteins)2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
CATH (Classification of proteins structures)2C9W    4JGH    5BO4    6I4X    6I5J    6I5N   
Human Protein Atlas [tissue]ENSG00000120833-SOCS2 [tissue]
Peptide AtlasO14508
IPIIPI00033944   IPI01010199   IPI01020907   IPI01022880   IPI01021714   IPI00978442   
Protein Interaction databases
IntAct (EBI)O14508
Ontologies - Pathways
Ontology : AmiGOregulation of cell growth  growth hormone receptor binding  insulin-like growth factor receptor binding  protein binding  cytoplasm  cytosol  phosphatidylinositol 3-kinase complex  JAK-STAT cascade  lactation  JAK pathway signal transduction adaptor activity  regulation of signal transduction  protein ubiquitination  response to estradiol  cellular response to hormone stimulus  intracellular signal transduction  interleukin-7-mediated signaling pathway  negative regulation of multicellular organism growth  negative regulation of apoptotic process  regulation of phosphatidylinositol 3-kinase activity  post-translational protein modification  positive regulation of neuron differentiation  negative regulation of JAK-STAT cascade  phosphatidylinositol phosphorylation  1-phosphatidylinositol-3-kinase regulator activity  growth hormone receptor signaling pathway  mammary gland alveolus development  
Ontology : EGO-EBIregulation of cell growth  growth hormone receptor binding  insulin-like growth factor receptor binding  protein binding  cytoplasm  cytosol  phosphatidylinositol 3-kinase complex  JAK-STAT cascade  lactation  JAK pathway signal transduction adaptor activity  regulation of signal transduction  protein ubiquitination  response to estradiol  cellular response to hormone stimulus  intracellular signal transduction  interleukin-7-mediated signaling pathway  negative regulation of multicellular organism growth  negative regulation of apoptotic process  regulation of phosphatidylinositol 3-kinase activity  post-translational protein modification  positive regulation of neuron differentiation  negative regulation of JAK-STAT cascade  phosphatidylinositol phosphorylation  1-phosphatidylinositol-3-kinase regulator activity  growth hormone receptor signaling pathway  mammary gland alveolus development  
Pathways : KEGGJak-STAT signaling pathway    Insulin signaling pathway    Prolactin signaling pathway    Type II diabetes mellitus   
REACTOMEO14508 [protein]
REACTOME PathwaysR-HSA-982772 [pathway]   
NDEx NetworkSOCS2
Atlas of Cancer Signalling NetworkSOCS2
Wikipedia pathwaysSOCS2
Orthology - Evolution
GeneTree (enSembl)ENSG00000120833
Phylogenetic Trees/Animal Genes : TreeFamSOCS2
Homologs : HomoloGeneSOCS2
Homology/Alignments : Family Browser (UCSC)SOCS2
Gene fusions - Rearrangements
Fusion : MitelmanWTAP/SOCS2 [6q25.3/12q22]  
Fusion PortalWTAP 6q25.3 SOCS2 12q22 PRAD
Fusion : Fusion_HubABCA8--SOCS2    AC011530.4--SOCS2    MNT--SOCS2    OAZ1--SOCS2    PFKFB3--SOCS2    SOCS2--ABHD17B    SOCS2--CRADD    SOCS2--EIF4A3    SOCS2--GNAS    SOCS2--KCTD7    SOCS2--RNPEP    SOCS2-AS1--SOCS2    TMEM116--SOCS2    TMTC2--SOCS2    WTAP--SOCS2   
Fusion : QuiverSOCS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOCS2 [hg38]
Exome Variant ServerSOCS2
GNOMAD BrowserENSG00000120833
Varsome BrowserSOCS2
Genomic Variants (DGV)SOCS2 [DGVbeta]
DECIPHERSOCS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOCS2 
ICGC Data PortalSOCS2 
TCGA Data PortalSOCS2 
Broad Tumor PortalSOCS2
OASIS PortalSOCS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOCS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOCS2
Mutations and Diseases : HGMDSOCS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOCS2
DgiDB (Drug Gene Interaction Database)SOCS2
DoCM (Curated mutations)SOCS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOCS2 (select a term)
NCG6 (London) select SOCS2
Cancer3DSOCS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry SOCS2
NextProtO14508 [Medical]
Target ValidationSOCS2
Huge Navigator SOCS2 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA128394542
Clinical trialSOCS2
canSAR (ICR)SOCS2 (select the gene name)
DataMed IndexSOCS2
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 19 18:00:40 CET 2021

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