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TACC3 (transforming, acidic coiled-coil containing protein 3)

Written2009-04Melissa R Eslinger, Brenda Lauffart, Ivan H Still
Department of Chemistry, Life Science Bartlett Hall, United States Military Academy, West Point, New York 10996, USA (MRE); Department of Physical Sciences, Arkansas Tech University, 1701 N Boulder Ave, Russellville, AR 72801, USA (BL); Department of Biological Sciences, Arkansas Tech University, 1701 N Boulder Ave, Russellville, AR 72801, USA (IHS)

(Note : for Links provided by Atlas : click)

Identity

Alias_namestransforming
Alias_symbol (synonym)ERIC1
Other aliasMGC117382
MGC133242
HGNC (Hugo) TACC3
LocusID (NCBI) 10460
Atlas_Id 42458
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 1721490 and ends at 1745178 bp from pter ( according to hg19-Feb_2009)  [Mapping TACC3.png]
 
Fusion genes
(updated 2016)
FGFR3 (4p16.3) / TACC3 (4p16.3)GNG7 (19p13.3) / TACC3 (4p16.3)KCTD3 (1q41) / TACC3 (4p16.3)
MAN2B2 (4p16.1) / TACC3 (4p16.3)WHSC1 (4p16.3) / TACC3 (4p16.3)

DNA/RNA

 
Description The gene is composed of 16 verified exons spanning 23.6kb.
Transcription Encodes a single confirmed 2788nt transcript (NM_006342) (Still et al., 1999), although one additional transcript with two additional small 5' coding exons between exon 1 and the first coding exon (exon 2), based on NM_006342, is indicated based on several cDNAs that may however be from suspect cDNA libraries (see UCSC Genome Bioinformatics Site (http://genome.ucsc.edu)). Four additional transcripts variants are suggested based on singleton Expressed sequence tags in tumor cell lines (AW516785, BE552327, BX331864) and/or stem cell progenitors (AV761182, CX872433).
Pseudogene None.

Protein

 
Description TACC3 encodes a single protein of 838 amino acids with a molecular mass of 90kDa (Still et al., 1999). The protein is heavily phosphorylated based on direct evidence and based on predictions from the Xenopus and mouse orthologs (Beausoleil et al., 2004; Beausoleil et al., 2008; Kinoshita et al., 2005; Yu et al., 2007; Cantin et al., 2008; Dephoure et al., 2008). Thus, human TACC3 migrates at approximately 150kDa in SDS-PAGE. Additional variants are suggested based on singleton cDNAs (see above) but their predicted protein isoforms have not been confirmed.
Expression High levels during early (mouse) embryogenesis, in particular during early differentiation of specific tissues (Sadek et al., 2003). In adult tissues, expression is relatively limited, with high levels noted in hematological tissues such as the thymus, spleen and leukocytes, and reproductive tissues, especially meiotic cells of the testes and ovary (Still et al., 1999; Sadek et al., 2003). Epithelial layers of the lung, mammary gland and ovary express TACC3 and alterations in expression are noted during tumorigenesis (see below). Expression in human adult tissues is summarized in Lauffart et al. 2006.
Localisation Human (and mouse) TACC3 is located in the interphase nucleus and/or cytosol, depending on cell type and cancer type (Gergely et al., 2000; Aitola et al., 2003; Lauffart et al., 2005; Jung et al., 2006; Vettaikkorumakankauv et al., 2008). TACC3 does not however contain a classical nuclear localisation signal (Still et al., 1999). TACC3 associates with the centrosome in a cell cycle dependent manner (Gergely et al., 2000). Phosphorylation of TACC3 by Aurora A on key serine residues is required for this interaction (Kinoshita et al., 2005; LeRoy et al., 2007). Overexpression of TACC3 from artificial constructs can result in accumulation in the cytosol of some cells resulting in oligmerisation in punctate structures (Gergely et al., 2000).
Function Gene knockout and knockdown studies in mouse have indicated that TACC3 is vital for embryonic development. A functionally null TACC3 mutant dies during mid to late gestation due to excessive apoptosis affecting hematopoietic and other organ systems (Piekorz et al., 2002). Hypomorphic alleles result in defects in mitosis affecting mesenchymal sclerotome and therefore the axial skeleton (Yao et al., 2007). These mutational mouse models indicate that TACC3 has a role in chromosomal alignment, separation and cytokinesis and that TACC3 can be associated with p53-mediated apoptosis.
TACC3 has a well characterized function in microtubule dynamics, particularly during mitosis, based on mutational analysis (see above) and physical interactions with Aurora A and Aurora B kinases, CKAP5 (ch-TOG/XMAP215) and AKAP9 via the TACC domain (see Peset and Vernos, 2008 for review). Interaction with CEP120 is important in interkinetic nuclear migration and maintenance of neural progenitor self-renewal during the development of the neocortex (Xie et al., 2007). Phosphorylation of Ser34, Ser552 and Ser558 by Aurora A are required for localization to centrosomes and is necessary for recruitment of CKAP5 and nucleation of microtubules (Kinoshita et al., 2005; LeRoy et al., 2007). Ser25, Thr59, Ser71, Ser317, and Ser 434 are presumed targets for cyclin dependent kinases in mitotic HeLa cells (Yu et al., 2007; Cantin et al., 2008; Dephoure et al., 2008). By homology, Ser558 phosphorylation by TPX2 is required for nucleation of microtubules in meiotic oocytes (Brunet et al., 2008).
TACC3 also has a defined role in interphase cells as a transcriptional cofactor for the aryl-nuclear translocator protein (Sadek, 2000), FOG1 (Garriga-Canut and Orkin, 2004; Simpson et al., 2004) and is a possible indirect activator of CREB via FHL family of coactivator/corepressor proteins (Lauffart et al., 2007b). Roles in transcriptional regulation have also been proposed based on TACC3 binding to GAS41 (YEATS4) via the SDP repeat, histone acetyl transferases hGCN5L2 (KAT2A), pCAF (KAT2B), and retinoid X-receptor beta via the TACC domain (Gangisetty, 2004; Lauffart et al., 2002; Vettaikkorumakankauv et al., 2008). TACC3 functionally interacts with MBD2 bound to methylated promoters, promoting transcription by displacement of HDAC2 and recruitment of KAT2B (Angrisano et al., 2006). Human TACC3 may be involved in transcriptional termination and/or pre-mRNA splicing through TTF2 (Leonard et al., 2003). TACC3 can interact with BARD1, BRCA1 and p53 and has been shown to have some protective affects against adriamycin-mediated DNA damage in ovarian cancer cells (Lauffart et al., 2007a). Phosphorylation of the last amino acid of the SDP repeat, Ser434, is noted in nuclear extracts of HeLa (Beausoleil, 2004; Beausoleil, 2006), although its functional significance is unknown.
Homology Member of the TACC family, based on the presence of the evolutionarily conserved approximately 200 amino acid carboxy terminal coiled coil domain (TACC domain) (Still et al., 1999; Still et al., 2004). TACC3 orthologues are noted in all vertebrates sequenced to date (Still et al., 2004 and Still unpublished). However, the central region between the conserved N-terminal region and the TACC domain is highly variable in size and sequence. The SDP repeats are noted within the central region in most vertebrates except mouse and rat (Still et al., 2004).

Mutations

Note Somatic mutations noted in ovarian cancer samples (Lauffart et al., 2005; Eslinger, 2006).
 
  See legend for normal protein.

Implicated in

Note
  
Entity Ovarian cancer
Prognosis Overexpression of TACC3 is associated with chemoresistance in ovarian tumors (L'Esperance et al., 2006).
Oncogenesis Total cellular expression or nuclear localization lost in ovarian cancer (Lauffart et al., 2005).
  
  
Entity Non-small cell lung cancer
Prognosis High TACC3 expression is an independent prognostic indicator associated with significantly shorter median survival time. TACC3 expression was correlated with p53 expression and poor prognosis (Jung et al., 2006).
Oncogenesis A high level of TACC3 expression was observed in 14.8% of cases of non small cell lung cancer, predominantly of the squamous cell carcinoma type (Jung et al., 2006).
  
  
Entity Breast cancer
Prognosis Loss of TACC3 is observed as a predictor of poor prognosis in breast cancer (Conte et al., 2002).
Oncogenesis TACC3 protein downregulated in breast cancer (Conte et al., 2002).
  
  
Entity Multiple myeloma
Prognosis TACC3 overexpression correlates with the t(4;14) translocation that is associated with poor prognosis (Stewart et al., 2004).
Oncogenesis TACC3 is located close to the MMSET gene that is rearranged in t(4;14) translocation (Still et al., 1999). This rearrangement upregulates the TACC3 gene (Stewart et al., 2004).
  
  
Entity Thyroid cancer
Prognosis Reduction of expression associated with increased malignancy in cell line models (Ulisse et al., 2007).
Oncogenesis Analysis of differentiated thyroid cancers indicates that TACC3 mRNA levels were either upregulated (44%) or downregulated (56%) in tumors, in some cases correlation was observed between TACC3 and Aurora-A kinase (Ulisse et al., 2007). However protein analysis was not reported.
  

Breakpoints

Note Rearrangements of the human TACC3 gene have not been described. However, translocation breakpoints in the WHSC1 gene, associated with multiple myeloma upregulate the intact TACC3 promoter (Stewart et al., 2004). Tacc3 in the mouse genome is a site of proviral integration of MoMuLV transmitted via milk from infected mothers. This leads to upregulation of the gene and leads to the development of lymphomas (Chakraborty et al., 2008).

Bibliography

Aint/Tacc3 is highly expressed in proliferating mouse tissues during development, spermatogenesis, and oogenesis.
Aitola M, Sadek CM, Gustafsson JA, Pelto-Huikko M.
J Histochem Cytochem. 2003 Apr;51(4):455-69.
PMID 12642624
 
TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters.
Angrisano T, Lembo F, Pero R, Natale F, Fusco A, Avvedimento VE, Bruni CB, Chiariotti L.
Nucleic Acids Res. 2006 Jan 12;34(1):364-72. Print 2006.
PMID 16410616
 
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP.
Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10.
PMID 16964243
 
Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes.
Brunet S, Dumont J, Lee KW, Kinoshita K, Hikal P, Gruss OJ, Maro B, Verlhac MH.
PLoS ONE. 2008 Oct 3;3(10):e3338.
PMID 18833336
 
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd.
J Proteome Res. 2008 Mar;7(3):1346-51. Epub 2008 Jan 26.
PMID 18220336
 
Retroviral gene insertion in breast milk mediated lymphomagenesis.
Chakraborty J, Okonta H, Bagalb H, Lee SJ, Fink B, Changanamkandat R, Duggan J.
Virology. 2008 Jul 20;377(1):100-9. Epub 2008 May 27.
PMID 18501945
 
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP.
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. Epub 2008 Jul 31.
PMID 18669648
 
Molecular Analysis of TACC3 in ovarian cancer.
Eslinger MR.
MS thesis, Department of Natural Science, Roswell Park Division, SUNY Buffalo 2006. 106p.
 
The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.
Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH.
Oncogene. 2004 Apr 1;23(14):2559-63.
PMID 14767476
 
Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis.
Garriga-Canut M, Orkin SH.
J Biol Chem. 2004 May 28;279(22):23597-605. Epub 2004 Mar 22.
PMID 15037632
 
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW.
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14352-7.
PMID 11121038
 
Protein expression profiling identifies subclasses of breast cancer and predicts prognosis.
Jacquemier J, Ginestier C, Rougemont J, Bardou VJ, Charafe-Jauffret E, Geneix J, Adelaide J, Koki A, Houvenaeghel G, Hassoun J, Maraninchi D, Viens P, Birnbaum D, Bertucci F.
Cancer Res. 2005 Feb 1;65(3):767-79.
PMID 15705873
 
Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer.
Jung CK, Jung JH, Park GS, Lee A, Kang CS, Lee KY.
Pathol Int. 2006 Sep;56(9):503-9.
PMID 16930330
 
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis.
Kinoshita K, Noetzel TL, Pelletier L, Mechtler K, Drechsel DN, Schwager A, Lee M, Raff JW, Hyman AA.
J Cell Biol. 2005 Sep 26;170(7):1047-55. Epub 2005 Sep 19.
PMID 16172205
 
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.
L'Esperance S, Popa I, Bachvarova M, Plante M, Patten N, Wu L, Tetu B, Bachvarov D.
Int J Oncol. 2006 Jul;29(1):5-24.
PMID 16773180
 
Interaction of TACC proteins with the FHL family: implications for ERK signaling.
Lauffart B, Sondarva GV, Gangisetty O, Cincotta M, Still IH.
J Cell Commun Signal. 2007b Jun;1(1):5-15. Epub 2007 Mar 28.
PMID 18481206
 
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.
Cancer Res. 2007 Jun 1;67(11):5362-70.
PMID 17545617
 
hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.
Leonard D, Ajuh P, Lamond AI, Legerski RJ.
Biochem Biophys Res Commun. 2003 Sep 5;308(4):793-801.
PMID 12927788
 
The TACC proteins: TACC-ling microtubule dynamics and centrosome function.
Peset I, Vernos I.
Trends Cell Biol. 2008 Aug;18(8):379-88. Epub 2008 Jul 23. (REVIEW)
PMID 18656360
 
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis.
Piekorz RP, Hoffmeyer A, Duntsch CD, McKay C, Nakajima H, Sexl V, Snyder L, Rehg J, Ihle JN.
EMBO J. 2002 Feb 15;21(4):653-64.
PMID 11847113
 
Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development.
Sadek CM, Jalaguier S, Feeney EP, Aitola M, Damdimopoulos AE, Pelto-Huikko M, Gustafsson JA.
Mech Dev. 2000 Oct;97(1-2):13-26.
PMID 11025203
 
TACC3 expression is tightly regulated during early differentiation.
Sadek CM, Pelto-Huikko M, Tujague M, Steffensen KR, Wennerholm M, Gustafsson JA.
Gene Expr Patterns. 2003 May;3(2):203-11.
PMID 12711550
 
A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3.
Simpson RJ, Yi Lee SH, Bartle N, Sum EY, Visvader JE, Matthews JM, Mackay JP, Crossley M.
J Biol Chem. 2004 Sep 17;279(38):39789-97. Epub 2004 Jul 2.
PMID 15234987
 
Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma.
Stewart JP, Thompson A, Santra M, Barlogie B, Lappin TR, Shaughnessy J Jr.
Br J Haematol. 2004 Jul;126(1):72-6.
PMID 15198734
 
Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms.
Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P.
BMC Evol Biol. 2004 Jun 18;4:16.
PMID 15207008
 
The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.
Still IH, Vince P, Cowell JK.
Genomics. 1999 Jun 1;58(2):165-70.
PMID 10366448
 
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
Ulisse S, Baldini E, Toller M, Delcros JG, Gueho A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y.
Endocr Relat Cancer. 2007 Sep;14(3):827-37.
PMID 17914111
 
The TACC proteins are coregulators of the Retinoid-X Receptor Beta.
Vettaikkorumakankauv AK, Lauffart B, Gangisetty O, Cincotta MA, Hawthorne LA, Cowell JK, Still IH.
Cancer Therapy. 2008 Dec;6(2):805-816.
 
Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.
Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH.
Neuron. 2007 Oct 4;56(1):79-93.
PMID 17920017
 
TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton.
Yao R, Natsume Y, Noda T.
Cancer Sci. 2007 Apr;98(4):555-62. Epub 2007 Mar 14.
PMID 17359303
 
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD.
J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9.
PMID 17924679
 

Citation

This paper should be referenced as such :
Eslinger, MR ; Lauffart, B ; Still, IH
TACC3 (transforming, acidic coiled-coil containing protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(3):305-310.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TACC3ID42458ch4p16.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  i(4p) in myeloid malignancies


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TACC3   11524
Cards
AtlasTACC3ID42458ch4p16
Entrez_Gene (NCBI)TACC3  10460  transforming acidic coiled-coil containing protein 3
AliasesERIC-1; ERIC1
GeneCards (Weizmann)TACC3
Ensembl hg19 (Hinxton)ENSG00000013810 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013810 [Gene_View]  chr4:1721490-1745178 [Contig_View]  TACC3 [Vega]
ICGC DataPortalENSG00000013810
TCGA cBioPortalTACC3
AceView (NCBI)TACC3
Genatlas (Paris)TACC3
WikiGenes10460
SOURCE (Princeton)TACC3
Genetics Home Reference (NIH)TACC3
Genomic and cartography
GoldenPath hg38 (UCSC)TACC3  -     chr4:1721490-1745178 +  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TACC3  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblTACC3 - 4p16.3 [CytoView hg19]  TACC3 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBITACC3 [Mapview hg19]  TACC3 [Mapview hg38]
OMIM605303   
Gene and transcription
Genbank (Entrez)AA682436 AF093543 AF479620 AI684124 AJ243997
RefSeq transcript (Entrez)NM_006342
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TACC3
Cluster EST : UnigeneHs.104019 [ NCBI ]
CGAP (NCI)Hs.104019
Alternative Splicing GalleryENSG00000013810
Gene ExpressionTACC3 [ NCBI-GEO ]   TACC3 [ EBI - ARRAY_EXPRESS ]   TACC3 [ SEEK ]   TACC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TACC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10460
GTEX Portal (Tissue expression)TACC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6A5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6A5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6A5
Splice isoforms : SwissVarQ9Y6A5
PhosPhoSitePlusQ9Y6A5
Domains : Interpro (EBI)TACC   
Domain families : Pfam (Sanger)TACC (PF05010)   
Domain families : Pfam (NCBI)pfam05010   
Conserved Domain (NCBI)TACC3
DMDM Disease mutations10460
Blocks (Seattle)TACC3
SuperfamilyQ9Y6A5
Human Protein AtlasENSG00000013810
Peptide AtlasQ9Y6A5
HPRD05601
IPIIPI00002135   IPI00946746   IPI00947073   IPI00946575   IPI00908659   IPI00966059   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6A5
IntAct (EBI)Q9Y6A5
FunCoupENSG00000013810
BioGRIDTACC3
STRING (EMBL)TACC3
ZODIACTACC3
Ontologies - Pathways
QuickGOQ9Y6A5
Ontology : AmiGOspindle pole  protein binding  cytoplasm  microtubule organizing center  metaphase/anaphase transition of mitotic cell cycle  cell proliferation  microtubule cytoskeleton  cerebral cortex development  cell division  regulation of mitotic spindle organization  microtubule cytoskeleton organization involved in mitosis  
Ontology : EGO-EBIspindle pole  protein binding  cytoplasm  microtubule organizing center  metaphase/anaphase transition of mitotic cell cycle  cell proliferation  microtubule cytoskeleton  cerebral cortex development  cell division  regulation of mitotic spindle organization  microtubule cytoskeleton organization involved in mitosis  
Pathways : KEGGRNA transport   
NDEx NetworkTACC3
Atlas of Cancer Signalling NetworkTACC3
Wikipedia pathwaysTACC3
Orthology - Evolution
OrthoDB10460
GeneTree (enSembl)ENSG00000013810
Phylogenetic Trees/Animal Genes : TreeFamTACC3
HOVERGENQ9Y6A5
HOGENOMQ9Y6A5
Homologs : HomoloGeneTACC3
Homology/Alignments : Family Browser (UCSC)TACC3
Gene fusions - Rearrangements
Fusion : MitelmanFGFR3/TACC3 [4p16.3/4p16.3]  [del(4)(p16p16)]  [t(4;4)(p16;p16)]  
Fusion : MitelmanGNG7/TACC3 [19p13.3/4p16.3]  [t(4;19)(p16;p13)]  
Fusion : MitelmanMAN2B2/TACC3 [4p16.1/4p16.3]  [t(4;4)(p16;p16)]  
Fusion : MitelmanWHSC1/TACC3 [4p16.3/4p16.3]  [t(4;4)(p16;p16)]  
Fusion : COSMICFGFR3 [4p16.3]  -  TACC3 [4p16.3]  [fusion_1348]  [fusion_1349]  [fusion_1350]  [fusion_1351]  [fusion_1352]  [fusion_1353]  [fusion_1354]  
[fusion_1355]  [fusion_1356]  [fusion_1357]  [fusion_1358]  [fusion_1359]  [fusion_1360]  [fusion_1361]  [fusion_1434]  [fusion_1435]  
Fusion: TCGAFGFR3 4p16.3 TACC3 4p16.3 BLCA GBM HNSC LGG LUSC
Fusion: TCGAGNG7 19p13.3 TACC3 4p16.3 LGG
Fusion: TCGAMAN2B2 4p16.1 TACC3 4p16.3 BLCA
Fusion: TCGAWHSC1 4p16.3 TACC3 4p16.3 BRCA
Fusion : TICdbFGFR3 [4p16.3]  -  TACC3 [4p16.3]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTACC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TACC3
dbVarTACC3
ClinVarTACC3
1000_GenomesTACC3 
Exome Variant ServerTACC3
ExAC (Exome Aggregation Consortium)TACC3 (select the gene name)
Genetic variants : HAPMAP10460
Genomic Variants (DGV)TACC3 [DGVbeta]
DECIPHERTACC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTACC3 
Mutations
ICGC Data PortalTACC3 
TCGA Data PortalTACC3 
Broad Tumor PortalTACC3
OASIS PortalTACC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTACC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTACC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TACC3
DgiDB (Drug Gene Interaction Database)TACC3
DoCM (Curated mutations)TACC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TACC3 (select a term)
intoGenTACC3
NCG5 (London)TACC3
Cancer3DTACC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605303   
Orphanet19649    19650   
MedgenTACC3
Ge.etkc Testing Registry TACC3
NextProtQ9Y6A5 [Medical]
TSGene10460
GENETestsTACC3
Target ValidationTACC3
Huge Navigator TACC3 [HugePedia]
snp3D : Map Gene to Disease10460
BioCentury BCIQTACC3
ClinGenTACC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10460
Chemical/Pharm GKB GenePA36301
Clinical trialTACC3
Miscellaneous
canSAR (ICR)TACC3 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTACC3
EVEXTACC3
GoPubMedTACC3
iHOPTACC3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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