Written | 2000-07 | Marie-Paule Lefranc |
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France |
Identity |
Alias (NCBI) | TRB@ (T cell Receptor Beta) |
HGNC (Hugo) | TRB |
HGNC Alias name | T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster |
HGNC Previous name | TCRB | TRB@ |
HGNC Previous name | TCRB, TRB@ |
LocusID (NCBI) | 6957 |
Atlas_Id | 24 |
Location | 7q34 [Link to chromosome band 7q34] |
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for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark | |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
Note | The human TRB locus is located on chromosome 7 on the long arm, at band 7q35. The orientation of the locus has been determined by the analysis of translocations, involving the TRB locus, in leukemia and lymphoma |
DNA/RNA |
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TRB V-GENE: Green box: Functional; Red: Pseudogene. D-GENE: Blue: Functional. J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene. C-GENE: Blue: Functional. for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark TRB V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene. D-GENE: Blue: Functional. J-GENE: Grey: Functional . C-GENE: Blue: Functional. GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene. for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark | |
Description | |
Protein |
Description | |
Mutations |
Note | Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles) |
Implicated in |
Note | |
Entity | Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints |
Entity | t(1;7)(p34;q35); involve TRB - LCK in 1p34 |
Disease | T-cell acute lymphocytic leukemia (ALL) |
Entity | t(1;7)(p32;q35); involve TRB - TAL1 in 1p32 |
Disease | T-cell acute lymphocytic leukemia (ALL) |
Prognosis | median survival > 5 yrs in children |
Entity | t(7;9)(q35;q32); involve TRB - TAL2 in 9q32 |
Disease | T-cell acute lymphocytic leukemia (ALL) |
Entity | t(7;9)(q35;q34); involve TRB - TAN1 in 9q34 |
Disease | T-cell acute lymphocytic leukemia (ALL) |
Entity | t(7;10)(q35;q24); involve TRB - HOX11 in 10q24 |
Disease | T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) |
Prognosis | not unfavourable |
Entity | t(7;11)(q35;p13); involve TRB - RBTN2 in 11p13 |
Disease | T-cell acute lymphocytic leukemia (ALL) |
Entity | t(7;14)(q35;q32); involve TRB - TCL1 in 14q32 |
Disease | T-cell lymphoproliferations |
Entity | t(7;19)(q35;p13); involve TRB - LYL1 in 19p13 |
Disease | T-cell acute lymphoblastic leukemia (ALL) |
Breakpoints |
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Bibliography |
The T cell Receptor FactsBook (Review) |
Lefranc M-P and Lefranc G |
Academic Press, London, UK (398 pages), 2001. ISBN: 124413528 |
Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review) |
Lefranc MP |
The immunologist,. 2000. |
Citation |
This paper should be referenced as such : |
Lefranc, MP |
TRB (T cell receptor beta) |
Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):119-120. |
Free journal version : [ pdf ] [ DOI ] |
Other Leukemias implicated (Data extracted from papers in the Atlas) [ 34 ] |
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Jan 1 19:02:37 CET 2021 |
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