| Identity |
| Other names | TRB (T cell Receptor Beta) |
| HGNC (Hugo) | TRB@ |
| Location | 7q35 |
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| for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ® ) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark | |
| Note | The human TRB locus is located on chromosome 7 on the long arm, at band 7q35. The orientation of the locus has been determined by the analysis of translocations, involving the TRB locus, in leukemia and lymphoma |
| DNA/RNA |
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| TRB V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene. D-GENE: Blue: Functional. J-GENE: Grey: Functional . C-GENE: Blue: Functional. GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene. for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information systemŽ) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark | |
| Description | |
| Protein |
| Description | |
| Mutations |
| Note | Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles) |
| Implicated in |
| Entity | Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints |
| Entity | t(1;7)(p34;q35); involve LCK in 1p34 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Entity | t(1;7)(p32;q35); involve TAL1 in 1p32 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Prognosis | median survival > 5 yrs in children |
| Entity | t(7;9)(q35;q32); involve TAL2 in 9q32 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Entity | t(7;9)(q35;q34); involve TAN1 in 9q34 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Entity | t(7;10)(q35;q24); involve HOX11 in 10q24 |
| Disease | T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) |
| Prognosis | not unfavourable |
| Entity | t(7;11)(q35;p13); involve RBTN2 in 11p13 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Entity | t(7;14)(q35;q32); involve TCL1 in 14q32 |
| Disease | T-cell lymphoproliferations |
| Entity | t(7;19)(q35;p13); involve LYL1 in 19p13 |
| Disease | T-cell acute lymphoblastic leukemia (ALL) |
| Breakpoints |
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| External links |
| Nomenclature | |
|---|---|
| HGNC (Hugo) | TRB@ 12155 |
| Entrez_Gene (NCBI) | TRB@ 6957 T cell receptor beta locus |
| Cards | |
| Atlas | TCRBID24 |
| GeneCards (Weizmann) | TRB@ |
| Ensembl (Hinxton) | [Gene_View] TRB@ [Vega] |
| AceView (NCBI) | TRB@ |
| Genatlas (Paris) | TRB@ |
| euGene (Indiana) | 6957 |
| SOURCE (Stanford) | |
| Genomic and cartography | |
| GoldenPath (UCSC) | TRB@ - 7q35 |
| Ensembl | TRB@ - [CytoView] |
| Mapping of homologs : NCBI | TRB@ [Mapview] |
| OMIM | 186930 |
| Gene and transcription | |
| Gene : Genbank (Entrez) | - |
| Reference sequence (RefSeq transcript) :SRS | |
| Reference transcript : Entrez | |
| RefSeq genomic : SRS | AC_000068 NG_001333 NT_079596 NW_001841498 |
| RefSeq genomic : Entrez | AC_000068 NG_001333 NT_079596 NW_001841498 |
| Consensus coding sequences : CCDS NCBI | TRB@ |
| Protein : pattern, domain, 3D structure | |
| Domain families : Pfam SRS | |
| Domain families : Pfam Sanger | |
| Domain families : Pfam NCBI | |
| Crystal structure of protein : PDB SRS | |
| Crystal structure of protein : PDBSum | |
| Crystal structure of protein : IMB | |
| Crystal structure of protein : PDB RSDB | |
| Protein Interaction databases | |
| Polymorphism : SNP, mutations, diseases | |
| Single Nucleotide Polymorphism (SNP) : dbSNP NCBI | TRB@ |
| SNP : GeneSNP Utah | TRB@ |
| SNP : HGBase | TRB@ |
| Genetic variants : HAPMAP | TRB@ |
| Cancer Gene: Census | TRB@ |
| Mutations and Diseases : HGMD | TRB@ |
| Hereditary diseases : OMIM | 186930 |
| Hereditary diseases : GENETests | 186930 |
| Diseases : Genetic Association | TRB@ |
| General knowledge | |
| Homologs : HomoloGene | TRB@ |
| Homology/Alignments : Family Browser UCSC | TRB@ |
| Phylogenetic Trees/Animal Genes : TreeFam | TRB@ |
| Chemical/Protein Interactions : CTD | 6957 |
| Keywords Ontology : AmiGO | |
| Keywords Ontology : EGO-EBI | |
| Pathways : BIOCARTA | |
| Pathways : KEGG | |
| Other databases | |
| Other database | TRB@ - IMGT |
| Probes | |
| Probes : Imagenes | TRB@ Related clones (RZPD - Berlin) |
| Literature | |
| PubMed | 63 Pubmed reference(s) in Entrez |
| PubGene | TRB@ |
| Bibliography |
| Nomenclature of the human T cell Receptor genes (Review) |
| Lefranc MP |
| Current Protocols in Immunology. 2000. |
| The T cell Receptor FactsBook (Review) |
| Lefranc MP and Lefranc G |
| Academic Press, London, UK (. 1939. |
| Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review) |
| Lefranc MP |
| The immunologist,. 2000. |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 07-2000 | Marie-Paule Lefranc |
| Updated | 09-2003 | Marie-Paule Lefranc |
| Citation |
| This paper should be referenced as such : |
| Lefranc MP . TRB@ (T cell Receptor Beta). Atlas Genet Cytogenet Oncol Haematol. July 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TCRBID24.html |
| Lefranc MP . TRB@ (T cell Receptor Beta). Atlas Genet Cytogenet Oncol Haematol. September 2003 . URL : http://AtlasGeneticsOncology.org/Genes/TCRBID24.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Aug 31 20:12:52 CEST 2010 |
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