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| | TRB
V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark TRB
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene.
for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark |
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| Description | The human TRB locus at 7q35 spans 620 kb. It consists of 64-67 TRBV genes belonging to 32 subgroups. Except for TRBV30, localized downstream of the TRBC2 gene, in inverted orientation of transcription, all the other TRBV genes are located upstream of a duplicated D-J-C-cluster, which comprises, for the first part one TRBD, six TRBJ, and the TRBC1 gene, and for the second part, one TRBD, eight TRBJ, and the TRBC2 gene. The most 5' TRBV genes occupy the most centromeric position, whereas the TRBV30 gene, 3' of the locus, is the most telomeric gene in the TRB locus. The potentiel repertoire consists of 39-46 functional TRBV genes belonging to 21-23 subgroups, the two TRBD, thirteen TRBJ (6 from the first cluster and 7 from the second cluster), and the two TRBC genes. Six TRBV orphons have been localized on chromosome 9 at 9p21. Enhancer sequences have been characterized 5.5kb 3' from TRBC2. List of the human TRB genes |
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| Entity | Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints |
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| Entity | ; involve TRB - LCK in 1p34 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
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| Entity | ; involve TRB - TAL1 in 1p32 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Prognosis | median survival > 5 yrs in children |
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| Entity | ; involve TRB - TAL2 in 9q32 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
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| Entity | ; involve TRB - TAN1 in 9q34 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
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| Entity | ; involve TRB - HOX11 in 10q24 |
| Disease | T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) |
| Prognosis | not unfavourable |
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| Entity | ; involve TRB - RBTN2 in 11p13 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
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| Entity | ; involve TRB - TCL1 in 14q32 |
| Disease | T-cell lymphoproliferations |
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| Entity | ; involve TRB - LYL1 in 19p13 |
| Disease | T-cell acute lymphoblastic leukemia (ALL) |
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