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TRB (T cell Receptor Beta)

Written2000-07Marie-Paule Lefranc
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

(Note : for Links provided by Atlas : click)


Alias_namesbeta polypeptide
T-cell receptor
Other aliasTRB@ (T cell Receptor Beta)
LocusID (NCBI) 6957
Atlas_Id 24
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 142299011 and ends at 142813287 bp from pter
  for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Note The human TRB locus is located on chromosome 7 on the long arm, at band 7q35. The orientation of the locus has been determined by the analysis of translocations, involving the TRB locus, in leukemia and lymphoma


V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark TRB
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene.
for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
  • The human TRB locus at 7q35 spans 620 kb. It consists of 64-67 TRBV genes belonging to 32 subgroups.
  • Except for TRBV30, localized downstream of the TRBC2 gene, in inverted orientation of transcription, all the other TRBV genes are located upstream of a duplicated D-J-C-cluster, which comprises, for the first part one TRBD, six TRBJ, and the TRBC1 gene, and for the second part, one TRBD, eight TRBJ, and the TRBC2 gene.
  • The most 5' TRBV genes occupy the most centromeric position, whereas the TRBV30 gene, 3' of the locus, is the most telomeric gene in the TRB locus.
  • The potentiel repertoire consists of 39-46 functional TRBV genes belonging to 21-23 subgroups, the two TRBD, thirteen TRBJ (6 from the first cluster and 7 from the second cluster), and the two TRBC genes.
  • Six TRBV orphons have been localized on chromosome 9 at 9p21. Enhancer sequences have been characterized 5.5kb 3' from TRBC2.
  • List of the human TRB genes
  • Protein

  • Proteins encoded by the TRB locus are the T cell receptor beta chains. They result from the recombination (or rearrangement), at the DNA level, of three genes: TRBV, TRBD and TRBJ, with deletion of the intermediary DNA to create a rearranged TRBV-D-J gene. The rearranged TRBV-D-J gene is transcribed with one of the two TRBC genes and translated into a T cell receptor beta chain.
  • Translation of the variable germline genes involved in the TRBV-D-J rearrangements are available at IMGT Repertoire Protein displays. TRB V-D-J rearrangements can be analysed using the IMGT/V-QUEST tool.
  • Mutations

    Note Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints
    Entity t(1;7)(p34;q35); involve LCK in 1p34
    Disease T-cell acute lymphocytic leukemia (ALL)
    Entity t(1;7)(p32;q35); involve TAL1 in 1p32
    Disease T-cell acute lymphocytic leukemia (ALL)
    Prognosis median survival > 5 yrs in children
    Entity t(7;9)(q35;q32); involve TAL2 in 9q32
    Disease T-cell acute lymphocytic leukemia (ALL)
    Entity t(7;9)(q35;q34); involve TAN1 in 9q34
    Disease T-cell acute lymphocytic leukemia (ALL)
    Entity t(7;10)(q35;q24); involve HOX11 in 10q24
    Disease T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
    Prognosis not unfavourable
    Entity t(7;11)(q35;p13); involve RBTN2 in 11p13
    Disease T-cell acute lymphocytic leukemia (ALL)
    Entity t(7;14)(q35;q32); involve TCL1 in 14q32
    Disease T-cell lymphoproliferations
    Entity t(7;19)(q35;p13); involve LYL1 in 19p13
    Disease T-cell acute lymphoblastic leukemia (ALL)




    The T cell Receptor FactsBook (Review)
    Lefranc M-P and Lefranc G
    Academic Press, London, UK (398 pages), 2001. ISBN: 124413528
    Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)
    Lefranc MP
    The immunologist,. 2000.


    This paper should be referenced as such :
    Lefranc, MP
    TRB (T cell receptor beta)
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):119-120.
    Free journal version : [ pdf ]   [ DOI ]
    On line version :

    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 18 ]
      t(10;14)(q24;q11) TLX1/TRD::t(7;10)(q34;q24) TRB/HOX11
    Hepatosplenic T-cell lymphoma (HSTCL)
    Intestinal T-cell lymphoma
    t(1;7)(p34;q34) TRB/LCK
    t(1;7)(p32;q34) TRB/TAL1::t(1;14)(p32;q11) TRA/TAL1::1p32 rearrangements
    t(6;7)(q23;q34) TRB/MYB and AHI1
    inv(7)(p15q34) TRB/HOXA10::t(7;7)(p15;q34) TRB/HOXA10
    t(7;9)(q34;q32) TRB/TAL2
    t(7;9)(q34;q34) TRB-NOTCH1
    t(7;12)(q34;p13) TRB/CCND2::t(12;14)(p13;q11) TRA or TRD/CCND2
    t(7;14)(p15;q11) TRD/HOXA10
    t(7;19)(q34;p13) TRB/LYL1
    t(X;7)(q22;q34) IRS4/TRB
    t(11;14)(p13;q11) TRD/LMO2::t(7;11)(q35;p13) TRB/LMO2
    t(20;21)(q13.2;q22.12) ZFP64/RUNX1
    T-lineage acute lymphoblastic leukemia (T-ALL)
    T-cell large granular lymphocyte leukaemia
    t(X;14)(q28;q11.2) TRA-TRD/MTCP1::t(X;7)(q28;q34) TRB/MTCP1

    External links

    HGNC (Hugo)TRB   12155
    Entrez_Gene (NCBI)TRB  6957  T-cell receptor beta locus
    AliasesTCRB; TRB@
    GeneCards (Weizmann)TRB
    Ensembl hg19 (Hinxton) [Gene_View]
    Ensembl hg38 (Hinxton) [Gene_View]  chr7:142299011-142813287 [Contig_View]  TRB [Vega]
    TCGA cBioPortalTRB
    AceView (NCBI)TRB
    Genatlas (Paris)TRB
    SOURCE (Princeton)TRB
    Genetics Home Reference (NIH)TRB
    Genomic and cartography
    GoldenPath hg38 (UCSC)TRB  -     chr7:142299011-142813287 7q34  hg19-Feb_2009   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)TRB  -     hg19-Feb_2009   [Description]    (hg19-Feb_2009)
    EnsemblTRB - hg19-Feb_2009 [CytoView hg19]  TRB - hg19-Feb_2009 [CytoView hg38]
    Mapping of homologs : NCBITRB [Mapview hg19]  TRB [Mapview hg38]
    Gene and transcription
    Genbank (Entrez)-
    RefSeq transcript (Entrez)
    RefSeq genomic (Entrez)NC_000007 NC_018918 NG_001333 NT_187562
    Consensus coding sequences : CCDS (NCBI)TRB
    Gene ExpressionTRB [ NCBI-GEO ]   TRB [ EBI - ARRAY_EXPRESS ]   TRB [ SEEK ]   TRB [ MEM ]
    Gene Expression Viewer (FireBrowse)TRB [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    BioGPS (Tissue expression)6957
    GTEX Portal (Tissue expression)TRB
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)TRB
    DMDM Disease mutations6957
    Blocks (Seattle)TRB
    Protein Interaction databases
    Ontologies - Pathways
    Huge Navigator TRB [HugePedia]
    snp3D : Map Gene to Disease6957
    BioCentury BCIQTRB
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD6957
    Chemical/Pharm GKB GenePA36837
    Clinical trialTRB
    canSAR (ICR)TRB (select the gene name)
    Other databaseTRB@ - IMGT
    PubMed108 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Mon Sep 18 17:15:56 CEST 2017

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