hsa-miR-373 (mature miRNA) Accession: MIMAT0000726 Length: 23 bp Sequence: 5-GAAGUGCUUCGAUUUUGGGGUGU-3
The miR-373 cluster was first described to be specifically expressed in embryonic stem cells and transcribed as a polycistronic transcript (Suh et al., 2004). The neighbouring C19MC cluster is thought to have originated from the miR-373 cluster (Zhang et al., 2008). miR-373 has been described to be epigenetically regulated by DNA methylation in colon cancer (Tanaka et al., 2011) and in a rare cancer type, hilar cholangiocarcinoma (Chen et al., 2012). Chromosomal alterations have been also linked to aberrant expression of miR-371-373 cluster. Indeed, 19q13.4 translocation in thyroid adenomas has been shown to activate both, C19MC and miR-371-373 clusters which are in close proximity to the chromosomal breakpoint cluster (Rippe et al., 2010). miR-371-373 cluster has also been reported to be transcriptionally regulated by WNT-signaling through β-catenin/LEF1 transactivation of the miR-371-373 promoter in both, breast (MCF-7) and colon (HCT-116) cancer cells (Zhou et al., 2012). Furthermore, miRNA microarray analysis revealed miR-373 to be upregulated under hypoxic conditions in a HIF-1α-dependent manner, in both HeLa and MCF-7 cancer cell lines that were exposed to hypoxia (0,01% O2) (Crosby et al., 2009).
NCBI: 442918 MIM: 611954 HGNC: 31787 Ensembl: ENSG00000199143 miRBase:
dbSNP: 442918 ClinVar: 442918 TCGA: ENSG00000199143 COSMIC: MIR373
Ioanna Keklikoglou ; Aoife Ward
MIR373 (microRNA 373)
Atlas Genet Cytogenet Oncol Haematol. 2013-08-01
Online version: http://atlasgeneticsoncology.org/gene/49739/mir373