t(1;14)(q21;q32) BCL9/IGH
t(1;22)(q21;q11) IGL/BCL9

2004-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL)

Epidemiology

a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient

Prognosis

prognosis was poor in 2 cases

Genes Involved and Proteins

Gene name
BCL9 (B-cell CLL/lymphoma 9)
Location
1q21.2
Protein description
involved in Wnt signal transduction
Gene name
IGL (Immunoglobulin Lambda)
Location
22q11.22
Note
Immunoglobulin genesImmunoglobulin genes

Bibliography

Pubmed IDLast YearTitleAuthors

Summary

Fusion gene

IGL/BCL9 IGL (22q11.22) BCL9 (1q21.2) M t(1;22)(q21;q11)

Note

the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other
This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement.

Citation

Jean-Loup Huret

t(1;14)(q21;q32) BCL9/IGH
t(1;22)(q21;q11) IGL/BCL9

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1319/cancer-prone-explorer/