RhoBTB2 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB2 is a putative tumour suppressor gene. Expression of RHOBTB2 has been found decreased in breast, lung and bladder tumors, head and neck squamous cell carcinoma and osteosarcoma. Decreased expression is often the result of promoter methylation. Mutations are uncommon. The role of RhoBTB2 in tumorigenesis is unknown but may be related to its function as a component of Cullin 3-dependent ubiquitin ligase complexes regulating the cell cycle and apoptosis.
NCBI: 23221 MIM: 607352 HGNC: 18756 Ensembl: ENSG00000008853
dbSNP: 23221 ClinVar: 23221 TCGA: ENSG00000008853 COSMIC: RHOBTB2
Kristina Schenková ; Shuo Cai ; Francisco Rivero
RHOBTB2 (Rho-related BTB domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2016-02-01
Online version: http://atlasgeneticsoncology.org/gene/42109/css/template-card.css
2008-12-01 RHOBTB2 (Rho-related BTB domain containing 2) by Kristina Schenková,Francisco Rivero  Affiliation