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t(14;19)(q11;q13) TRA::NECTIN2

Written2019-09Jean Loup Huret

Abstract Review on t(14;19)(q11;q13), with data on clinics, and the genes involved.

Keywords Chromosome 14; chromosome 19; TRA; NECTIN2; peripheral T-cell lymphoma; angioimmunoblastic T-cell lymphoma.

(Note : for Links provided by Atlas : click)


ICD-Topo C420,C421,C424
ICD-Morpho 9702/3 Peripheral T-cell lymphoma, NOS; Anaplastic large cell lymphoma, ALK negative
ICD-Morpho 9705/3 Angioimmunoblastic T-cell lymphoma
Atlas_Id 1513

Clinics and Pathology

Disease T-cell lymphomas
Epidemiology Four cases available to date: three peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) (two male patients aged 20 and 63 yrs and one female patient aged 63 yrs), and one angioimmunoblastic T-cell lymphoma (Lepretre et al., 2000; Almire et al., 2007; Shin et al., 212).
Other features Recently, the cell line T8ML-1 with t(14;19) TRA/NECTIN2 was established from a 64-year old female patient diagnosed with fatal PTCL-NOS (Ehrentraut et al., 2017).


Cytogenetics Morphological The karyotype was complex in all four cases.

Genes involved and Proteins

Gene NameTRA (T cell Receptor Alpha)
Location 14q11.2
Gene NameNECTIN2 (nectin cell adhesion molecule 2)
Location 19q13.32
Note NECTIN2 is also called PVRL2 (poliovirus receptor-related 2).
Protein NECTIN2 is a cell membrane protein involved in immune checkpoint, part of the TIGIT-PVR/PVRL2 axis. NECTIN2 is composed of a signal peptide (amino acids (aa) 1-31), an extracellular domain (aa 32-360), a transmembrane domain (aa 361-381), and a cytoplasmic domain (aa 382-538). NECTIN2 also interacts with PVRIG CD226, CD96 to stimulate or inhibit lymphocyte cell signaling (Stamm et al., 2018; Whelan et al., 2019).

Result of the chromosomal anomaly

Hybrid gene
Note On chromosome 19, there was a cluster of breakpoints in the NECTIN2 gene region, 130 kb downstream of BCL3. The breakpoints on chromosome 14 were located in theTRAJ region (Almire et al., 2007).
Fusion Protein
Oncogenesis NECTIN2 was highly expressed in the t(14;19)(q11;q13)-positive tumors.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11
Ehrentraut S, Nagel S, Pommerenke C, Dirks WG, Quentmeier H, Kaufmann M, Meyer C, Zaborski M, Geffers R, Fujiwara H, Drexler HG, MacLeod RAF
2;q13 3)
PMID 28659334
Chromosome abnormalities in peripheral T-cell lymphoma.
Lepretre S, Buchonnet G, Stamatoullas A, Lenain P, Duval C, d'Anjou J, Callat M-P, Tilly H, Bastard C,
Cancer Genet Cytogenet 2000; 117:71-79.
A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11
Shin SY, Jang S, Park CJ, Chi HS, Lee KH, Huh J, Seo EJ
2;q13 3)
PMID 22122800
Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer
Stamm H, Wellbrock J, Fiedler W
Mamm Genome 2018 Dec;29(11-12):694-702
PMID 30132062
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function
Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K, Bernados D, Murter B, Soni A, Taube JM, Fader AN, Wang TL, Shih IM, White M, Pardoll DM, Liang SC
Cancer Immunol Res 2019 Feb;7(2):257-268
PMID 30659054


This paper should be referenced as such :
Jean Loup Huret
t(14;19)(q11;q13) TRA/NECTIN2
Atlas Genet Cytogenet Oncol Haematol. 2020;24(6):253-254.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(14;19)(q11;q13) TRA/NECTIN2

External links

Mitelman databaset(14;19)(q11;q13)
arrayMap (UZH-SIB Zurich)Morph ( 9702/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9705/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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