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GFI1B (growth factor independent 1B transcription repressor)

Written2010-06Lothar Vassen, Tarik Möröy
Research Unit Hematopoiesis, Cancer, Institut de recherches cliniques de Montreal,110 avenue des Pins Ouest, Montreal (Quebec) H2W 1R7, Canada

(Note : for Links provided by Atlas : click)

Identity

HGNC (Hugo) GFI1B
LocusID (NCBI) 8328
Atlas_Id 40707
Location 9q34.13  [Link to chromosome band 9q34]
Location_base_pair Starts at 135854098 and ends at 135867084 bp from pter ( according to hg19-Feb_2009)  [Mapping GFI1B.png]
Local_order The human GFI1B gene is telomeric to TSC1 (tuberous sclerosis 1 protein) and centromeric to GTF3C5 (general transcription factor 3C polypeptide 5).

DNA/RNA

Description The GFI1B gene structure is composed of at least 7 exons (ranging from 120 to 824 bp), six of which are coding. Spliced ESTs and human mRNAs may define up to eight additional 5'exons which possibly point to an alternative promoter close to the promoter of TSC1.
Transcription Two human mRNA transcripts arise from alternative splicing. GFI1B mRNA variant one encodes the more frequent full length GFI1B (330 aa), while variant two lacks the in frame exon 5 (according to the NCBI RefSeq for hGFI1B) leading to a shorter isoform (284 aa) lacking zinc-finger two and parts of zinc-finger one and three. The residual parts of Znf one and three are joined to form a new zinc-finger (see mRNA and protein below).
Pseudogene Unknown.

Protein

Note The longer GFI1B variant 1 is the protein refered to in most cases. GFI1B variant 2 shows only a restricted expression in normal cells and could be preferentially associated with leukemic diseases. Functional differences between both proteins are not described yet.
 
  Model for the generation of the two major GFI1B isoforms. GFI1B-V2 is translated from a shorter mRNA splice variant where exon 9 is skipped (aa 171-216 missing). There are many potential 5' transcriptional start sites, but the major start site seems to be in exon 5, corresponding to exon 1 (122 bp) in the RefSeq database.
SD: SNAG domain necessary for repression of transcription by GFI1B.
ID: Intermediary domain with very low homology to the GFI1B homolog GFI1 and unknown function, which is presumably important for specific protein-protein interactions unique to GFI1B.
Znf 1-6: C2H2 zinc-finger domains which are highly conserved between all members of the GFI1 protein family. Znf 3-5 bind to the major groove of target DNA. Znf 4-5 of GFI1B (almost identical to GFI1) recognize a AATC DNA core sequence in the GFI1/GFI1B predicted binding site.
Description GFI1B (isoform 1) is a protein of 330 aa residues and has a predicted molecular mass of 37492.38 Da. Isoelectric point: 9.3076, charge: 25.0, average residue weight: 113613.
GFI1B is composed of a 20-amino-acid N-terminal SNAG (SNAIL-GFI) transcription repressor domain, and intermediary domain of largely unknown function and six c-terminal C2H2 zinc-finger domains encompassing residues 163-327. Zinc-fingers 3-5 are involved in sequence specific DNA binding and recognize a taAATCaca/tgca/t core motif. The bases flanking the AATC core motif seem to be poorly conserved. Predictions of true GFI1B binding sites in the genome based only on this sequence have to be validated independently.
Expression GFI1B is mainly expressed in the fetal and adult hematopoietic system, where it is detected in hematopoietic stem cells, megakaryocyte/erythroid precursors (MEP), common myeloid precursors (CMP), erythroblasts and early erythrocytes, megakaryocytes and megakaryocyte precursors, B-cell precursors and a small subset of T-cell precursors (Vassen et al., 2007). GFI1B is lso detected in fetal thymus and testes. GFI1B expression varies throughout the maturation of these cells, with the highest expression levels in MEPs, megakaryocytes and erythrocytes and seems to be tightly regulated. The shorter isoform 2 of GFI1B is lowly expressed in normal cells, but upregulated in several types of leukemia (e.g. chronic myelogenous leukemia, acute myeloid leukemia, erythroleukemia, megakaryocytic leukemia). The expression of GFI1B is described to be positively regulated by GATA-1, NF-Y, E2-alpha/TCF3, and HMGB2 and to be repressed by Oct1, GFI1B and GFI1. GFI1B expression is down-regulated by erythropoietin (EPO) in a signal-transducer-and-activator-of-transcription-5 (STAT5) dependent manner.
Localisation Almost exclusively nuclear, frequently accumulating in foci of pericentric heterochromatin.
Function Negative regulation of transcription. GFI1B is an essential factor in erythroid and megakaryocytic development and differentiation, very likely with proto-oncogenic potential. GFI1B deficiency leads to embryonic lethality in mice due to failure to produce functional erythrocytes and megakaryocytes and increases the apoptosis rate in leukemic cell lines. The GFI1B gene locus can be autoregulated by autorepression of its own promoter in hematopoietic cells (Vassen et al., 2005; Anguita et al., 2010), most likely by interaction with GATA1 (GATA binding protein 1) (Huang et al., 2005), an activator of GFI1B transcription that is also essential for erythroid and megakaryocytic development. GFI1B and its homolog GFI1 show cross-repression, resulting in an enhanced expression of the respective counterpart, when one of these genes is deleted. The repressory activity of GFI1B is achieved by recruiting histone deacetylases (HDAC1 and HDAC2), lysine specific demethylase 1 (LSD1 or KDM1) and the REST corepressor (CoREST) to target DNA sequences (Saleque et al., 2007). GFI1B alters histone methylation at target gene promoters and is associated with sites of gamma-satellite containing heterochromatin (Vassen et al., 2006). GFI1B interacts also with the histone methyltransferases G9a and SUV39H1 and a role in heterochromatin formation is hypothesized (Vassen et al., 2006). GFI1B target genes (e.g. BCL2L1, SOCS1, SOCS3, CDKN1A, GATA3) are frequently also GATA1 target genes (e.g. GFI1B, GATA2, Myb, Myc) and GFI1B is overrepresented at sites where GATA1 binds to repress its target genes (Yu et al., 2009). GATA2 needs to be repressed by GATA1 in developing erythroid cells pointing to an involvement of a GATA1-GFI1B repressory complex in this process. GATA1 and GFI1B have been found in a complex with SUZ12, a member of the polycomb repressory complex 2 (PRC2, SUZ12 and Eed) on repressed genes in MEL (erythroleukemia) cells (Yu et al., 2009). Since GFI1B is also expressed in hematopoietic stem cells (HSC), the existence of such a repressory complex might point to a role of GFI1B in maintaining HSC self renewal, where PCR complexes play a major role. Consistent with this hypothesis, GFI1B can functionally replace GFI1 during hematopoiesis but not in the development of inner ear hair cells, where GFI1 exerts a critical survival function (Fiolka et al., 2006; Wallis et al., 2003). An implication of GFI1B in sensory epithelial cells similar to GFI1 remains to be elucidated. In megakaryocytes GFI1B is found in a complex with GATA1 and ETO2, another corepressor protein that is also implicated in human leukemogenesis (Hamlett et al., 2008), but how GFI1B regulates megakaryocytic development is not clear yet. GFI1B regulates TGF-beta signaling in bipotent erythroid-megakaryocytic progenitors (Randrianarison-Huetz, 2010), which is involved in the control of their differentiation. Finally, GFI1B regulates the expression of GATA3 in T-cell lymphomas, a critical factor for survival of lymphomas and T-cell progenitors (Wei and Kee, 2007).
Positive regulation of transcription. GFI1B can activate transcription from a promoter containing four GFI1 consensus-sites in the erythroid cell line K562 (Osawa et al., 2002).
Homology GFI1B is highly homologous to its closest relative GFI1. Highly conserved GFI1(B) proteins have been detected in many species from C. elegans to drosophila and human.

Mutations

Germinal A single base mutation in the GFI1B promoter (T-C) was detected affecting a potential Oct-1 binding site in an acute lymphoblastic leukemia patient. The mutation was shown to affect the promoter activity, leading to an increased expression of GFI1B. (Hernández et al., 2010).
Somatic A natural variant (p.R231H) was detected in a colorectal cancer sample. A GFI1B promoter mutation was detected in an acute myeloid leukemia M5a patient, affecting a GATA1 binding site which was previously shown to be involved in the regulation of GFI1B expression. (Hernández et al., 2010).

Implicated in

Note
Entity Leukemia
Note GFI1B was shown to be highly overexpressed in various leukemias (Elmaagacli et al., 2007; Vassen et al., 2009). Knock down of GFI1B in leukemia cell lines markedly increased the apoptosis rate of these cells (Elmaagacli et al., 2007), pointing to a role of GFI1B in protection against apoptosis. Overexpression of GFI1B in human CD34+ hematopoietic progenitors induced an expansion of erythroblasts, independent from erythropoietin, pointing to a role of GFI1B in regulation of proliferation (Osawa et al., 2002). Since reduced apoptosis and enhanced proliferation both are involved in leukemogenesis, GFI1B may play an important role in these diseases. Additionally, the GFI1B locus was found in a retroviral insertion mutagenesis screen for factors, cooperating with EGR1 haploinsufficiency to induce myeloid leukemias in the mouse (Quian et al., 2010).
Disease Chronic myeloid leukemia (CML), essential thrombocythemia (ET), myelodysplastic syndrome (MDS), myeloproliferative syndrome (MPS), B-cell acute lymphocytic leukemia (B-ALL), acute myeloid leukemia (AML), erythroleukemia (EL), megakaryocytic/megakaryoblastic leukemias.
  

Breakpoints

Note Translocated along with ABL1 in chronic myeloid leukemia with translocation t(9:22).

Bibliography

GFI1B controls its own expression binding to multiple sites.
Anguita E, Villegas A, Iborra F, Hernandez A.
Haematologica. 2010 Jan;95(1):36-46. Epub 2009 Sep 22.
PMID 19773260
 
Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate.
Elmaagacli AH, Koldehoff M, Zakrzewski JL, Steckel NK, Ottinger H, Beelen DW.
Br J Haematol. 2007 Jan;136(2):212-9. Epub 2006 Dec 8.
PMID 17156408
 
Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.
Fiolka K, Hertzano R, Vassen L, Zeng H, Hermesh O, Avraham KB, Duhrsen U, Moroy T.
EMBO Rep. 2006 Mar;7(3):326-33. Epub 2006 Jan 6.
PMID 16397623
 
Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.
Garcon L, Lacout C, Svinartchouk F, Le Couedic JP, Villeval JL, Vainchenker W, Dumenil D.
Blood. 2005 Feb 15;105(4):1448-55. Epub 2004 Oct 26.
PMID 15507521
 
Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation.
Hamlett I, Draper J, Strouboulis J, Iborra F, Porcher C, Vyas P.
Blood. 2008 Oct 1;112(7):2738-49. Epub 2008 Jul 14.
PMID 18625887
 
Human promoter mutations unveil Oct-1 and GATA-1 opposite action on Gfi1b regulation.
Hernandez A, Villegas A, Anguita E.
Ann Hematol. 2010 Aug;89(8):759-65. Epub 2010 Feb 9.
PMID 20143233
 
GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells.
Huang DY, Kuo YY, Chang ZF.
Nucleic Acids Res. 2005 Sep 21;33(16):5331-42. Print 2005.
PMID 16177182
 
Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.
Jegalian AG, Wu H.
J Biol Chem. 2002 Jan 18;277(3):2345-52. Epub 2001 Nov 5.
PMID 11696536
 
Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cells.
Koldehoff M, Zakrzewski JL, Klein-Hitpass L, Beelen DW, Elmaagacli AH.
Int J Hematol. 2008 Jan;87(1):39-47. Epub 2007 Dec 6.
PMID 18224412
 
GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription.
Kuo YY, Chang ZF.
Mol Cell Biol. 2007 Jun;27(12):4261-72. Epub 2007 Apr 9.
PMID 17420275
 
High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription.
Laurent B, Randrianarison-Huetz V, Marchal V, Mayeux P, Dusanter-Fourt I, Dumenil D.
Blood. 2010 Jan 21;115(3):687-95. Epub 2009 Nov 24.
PMID 19965638
 
Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.
Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, Iwama A.
Blood. 2002 Oct 15;100(8):2769-77.
PMID 12351384
 
Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.
Qian Z, Joslin JM, Tennant TR, Reshmi SC, Young DJ, Stoddart A, Larson RA, Le Beau MM.
Chem Biol Interact. 2010 Mar 19;184(1-2):50-7. Epub 2009 Dec 1. (REVIEW)
PMID 19958752
 
Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.
Randrianarison-Huetz V, Laurent B, Bardet V, Blobe GC, Huetz F, Dumenil D.
Blood. 2010 Apr 8;115(14):2784-95. Epub 2010 Feb 2.
PMID 20124515
 
The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases.
Rodel B, Wagner T, Zornig M, Niessing J, Moroy T.
Genomics. 1998 Dec 15;54(3):580-2.
PMID 9878267
 
GATA-1 forms distinct activating and repressive complexes in erythroid cells.
Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J.
EMBO J. 2005 Jul 6;24(13):2354-66. Epub 2005 May 26.
PMID 15920471
 
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.
Saleque S, Kim J, Rooke HM, Orkin SH.
Mol Cell. 2007 Aug 17;27(4):562-72.
PMID 17707228
 
The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.
Tong B, Grimes HL, Yang TY, Bear SE, Qin Z, Du K, El-Deiry WS, Tsichlis PN.
Mol Cell Biol. 1998 May;18(5):2462-73.
PMID 9566867
 
Erythropoiesis: model systems, molecular regulators, and developmental programs.
Tsiftsoglou AS, Vizirianakis IS, Strouboulis J.
IUBMB Life. 2009 Aug;61(8):800-30. (REVIEW)
PMID 19621348
 
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.
Vassen L, Fiolka K, Moroy T.
EMBO J. 2006 Jun 7;25(11):2409-19. Epub 2006 May 11.
PMID 16688220
 
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.
Vassen L, Khandanpour C, Ebeling P, van der Reijden BA, Jansen JH, Mahlmann S, Duhrsen U, Moroy T.
Int J Hematol. 2009 May;89(4):422-30. Epub 2009 Apr 10.
PMID 19360458
 
Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.
Vassen L, Okayama T, Moroy T.
Blood. 2007 Mar 15;109(6):2356-64. Epub 2006 Nov 9.
PMID 17095621
 
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.
Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ.
Development. 2003 Jan;130(1):221-32.
PMID 12441305
 
Erythroid and megakaryocytic transformation.
Wickrema A, Crispino JD.
Oncogene. 2007 Oct 15;26(47):6803-15. (REVIEW)
PMID 17934487
 
Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.
Xu W, Kee BL.
Blood. 2007 May 15;109(10):4406-14. Epub 2007 Feb 1.
PMID 17272506
 
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB.
Mol Cell. 2009 Nov 25;36(4):682-95.
PMID 19941827
 
Inferring the functional effects of mutation through clusters of mutations in homologous proteins.
Yue P, Forrest WF, Kaminker JS, Lohr S, Zhang Z, Cavet G.
Hum Mutat. 2010 Mar;31(3):264-71.
PMID 20052764
 

Citation

This paper should be referenced as such :
Möröy, T ; Vassen, L
GFI1B (growth factor independent 1B transcription repressor)
Atlas Genet Cytogenet Oncol Haematol. 2011;15(3):266-269.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/GFI1BID40707ch9q34.html


External links

Nomenclature
HGNC (Hugo)GFI1B   4238
Cards
AtlasGFI1BID40707ch9q34
Entrez_Gene (NCBI)GFI1B  8328  growth factor independent 1B transcription repressor
AliasesBDPLT17; ZNF163B
GeneCards (Weizmann)GFI1B
Ensembl hg19 (Hinxton)ENSG00000165702 [Gene_View]  chr9:135854098-135867084 [Contig_View]  GFI1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000165702 [Gene_View]  chr9:135854098-135867084 [Contig_View]  GFI1B [Vega]
ICGC DataPortalENSG00000165702
TCGA cBioPortalGFI1B
AceView (NCBI)GFI1B
Genatlas (Paris)GFI1B
WikiGenes8328
SOURCE (Princeton)GFI1B
Genomic and cartography
GoldenPath hg19 (UCSC)GFI1B  -     chr9:135854098-135867084 +  9q34.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GFI1B  -     9q34.13   [Description]    (hg38-Dec_2013)
EnsemblGFI1B - 9q34.13 [CytoView hg19]  GFI1B - 9q34.13 [CytoView hg38]
Mapping of homologs : NCBIGFI1B [Mapview hg19]  GFI1B [Mapview hg38]
OMIM187900   604383   
Gene and transcription
Genbank (Entrez)AF081946 AI097490 AY428733 BC035626 BC043371
RefSeq transcript (Entrez)NM_001135031 NM_004188
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_034227 NT_008470 NW_004929367
Consensus coding sequences : CCDS (NCBI)GFI1B
Cluster EST : UnigeneHs.553160 [ NCBI ]
CGAP (NCI)Hs.553160
Alternative Splicing GalleryENSG00000165702
Gene ExpressionGFI1B [ NCBI-GEO ]   GFI1B [ EBI - ARRAY_EXPRESS ]   GFI1B [ SEEK ]   GFI1B [ MEM ]
Gene Expression Viewer (FireBrowse)GFI1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8328
GTEX Portal (Tissue expression)GFI1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VTD9 (Uniprot)
NextProtQ5VTD9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VTD9
Splice isoforms : SwissVarQ5VTD9 (Swissvar)
PhosPhoSitePlusQ5VTD9
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)GFI1/1B    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)    zf-C2H2_6 (PF13912)   
Domain families : Pfam (NCBI)pfam00096    pfam13912   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations8328
Blocks (Seattle)GFI1B
SuperfamilyQ5VTD9
Human Protein AtlasENSG00000165702
Peptide AtlasQ5VTD9
HPRD05088
IPIIPI00003110   IPI00479652   
Protein Interaction databases
DIP (DOE-UCLA)Q5VTD9
IntAct (EBI)Q5VTD9
FunCoupENSG00000165702
BioGRIDGFI1B
STRING (EMBL)GFI1B
ZODIACGFI1B
Ontologies - Pathways
QuickGOQ5VTD9
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor binding  DNA binding  protein binding  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  cell proliferation  nuclear matrix  chromatin modification  hemopoiesis  metal ion binding  regulation of histone H3-K4 methylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor binding  DNA binding  protein binding  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  cell proliferation  nuclear matrix  chromatin modification  hemopoiesis  metal ion binding  regulation of histone H3-K4 methylation  
NDEx NetworkGFI1B
Atlas of Cancer Signalling NetworkGFI1B
Wikipedia pathwaysGFI1B
Orthology - Evolution
OrthoDB8328
GeneTree (enSembl)ENSG00000165702
Phylogenetic Trees/Animal Genes : TreeFamGFI1B
Homologs : HomoloGeneGFI1B
Homology/Alignments : Family Browser (UCSC)GFI1B
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGFI1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFI1B
dbVarGFI1B
ClinVarGFI1B
1000_GenomesGFI1B 
Exome Variant ServerGFI1B
ExAC (Exome Aggregation Consortium)GFI1B (select the gene name)
Genetic variants : HAPMAP8328
Genomic Variants (DGV)GFI1B [DGVbeta]
Mutations
ICGC Data PortalGFI1B 
TCGA Data PortalGFI1B 
Broad Tumor PortalGFI1B
OASIS PortalGFI1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFI1B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GFI1B
DgiDB (Drug Gene Interaction Database)GFI1B
DoCM (Curated mutations)GFI1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GFI1B (select a term)
intoGenGFI1B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:135854098-135867084  ENSG00000165702
CONAN: Copy Number AnalysisGFI1B 
Mutations and Diseases : HGMDGFI1B
OMIM187900    604383   
MedgenGFI1B
Genetic Testing Registry GFI1B
NextProtQ5VTD9 [Medical]
TSGene8328
GENETestsGFI1B
Huge Navigator GFI1B [HugePedia]
snp3D : Map Gene to Disease8328
BioCentury BCIQGFI1B
ClinGenGFI1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8328
Chemical/Pharm GKB GenePA28649
Clinical trialGFI1B
Miscellaneous
canSAR (ICR)GFI1B (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGFI1B
EVEXGFI1B
GoPubMedGFI1B
iHOPGFI1B
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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