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KLK7 (kallikrein-related peptidase 7)

Written2009-05Ying Dong, John Lai, Judith A Clements
Hormone Dependent Cancer Program, Institute of Health, Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Australia

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPRSS6
kallikrein 7 (chymotryptic
Alias_symbol (synonym)SCCE
Other aliashK7
hSCCE
HGNC (Hugo) KLK7
LocusID (NCBI) 5650
Atlas_Id 41087
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 51479735 and ends at 51487320 bp from pter ( according to hg19-Feb_2009)  [Mapping KLK7.png]
Local_order Telomere to centromere.
 
  Genomic and protein structure of the KLK7 gene. The KLK7 gene is classically comprised of 5 coding exons (red boxes, classic numerals) and 4 intervening introns with a conserved intron phase pattern (I, II, I, 0). A non-coding exon and untranslated regions are shown in yellow. Also shown is the classical transcription initiation site (TIS) and corresponding translation start site (ATG1). An exon 1 deleted transcript has also been identified which would potentially result in the use of an alternative translation start site (ATG2). The numbering for the amino acid residues of the catalytic triad (His70, Asp112, Ser205) are relative to the full-length protein starting from ATG1.
Fusion genes
(updated 2016)
BBOX1 (11p14.2) / KLK7 (19q13.41)KDM4C (9p24.1) / KLK7 (19q13.41)

DNA/RNA

Description The gene encompasses 6.509 kb of gDNA.
Transcription Five variant mRNA transcripts have been identified. These include transcripts using different 5' untranslated regions (UTRs) including exon 1 deletions, and transcripts using different 3'UTR regions. Using rapid amplification of cDNA ends (RACE) different KLK7 5'UTR sequences were identified from RNA extracted from pancreas, skin and ovarian cells, suggesting the expression of tissue specific KLK7 transcripts.
Pseudogene Not identified.

Protein

Description Full-length KLK7 (253 amino acids) has a secretion signal (pre-) peptide (22 amino acids), followed by an activation (pro-) peptide (7 amino acids) and the mature chain (224 amino acids) with 1 potential N-linked glycosylation site. The catalytic triad of His70, Asp112 and Ser205 (relative to ATG1) is conserved and is essential for proteolytic activity. After synthesis as a KLK7 full-length protein, the signal peptide is then cleaved and pro-KLK7 (zymogen) is subsequently secreted from the cell. On activation, the propeptide is removed and the zymogen becomes the mature active enzyme. KLK7 can complex with antileukoprotease (secretory leukocyte protease inhibitor), elafin, Lympho-epithelial Kazal type inhibitor (LEKTI) fragments, and a member of a2-macroglobulin (a2M) protease inhibitor family, a2-macroglobulin-like 1 (a2ML1).
X-ray structures of recombinant full-length KLK7 from E. coli and insect cells have been solved, from which the most distinguishing features of KLK7 are the short 70-80 loop and the unique S1 pocket, which prefers P1 Tyr residues. KLK7 displays a unique chymotrypsin-like specificity for Tyr, which is preferred at P2. In addition, KLK7 exhibits large positively charged surface patches, representing putative exosites for prime side substrate recognition.
Similar to several other KLKs and based on the binding of metal to histidine such as His99, the KLK7 activity is inhibited by Zn++ and Cu++ at low micromolar concentrations. KLK7 induced degradation of corneodesmosin and desmocollin 1 with similar efficiency in acidic (pH 5.6) and neutral (pH 7.2) conditions. KLK7 activity is modulated by water content in stratum corneum as KLK7 activity increased significantly in an environment of high relative humidity. KLK7 also demonstrated a tolerance to water restriction suggesting that it may be adapted to function in the water-restricted stratum corneum. Thus, relative humidity modulates desquamation by its effect upon KLK7 activity, possibly other desquamatory hydrolases and adapted KLK7 function in water-deplete skin.
An N-terminal truncated KLK7 isoform (181 amino acids) initiating from the putative ATG2 would not have the pre-pro-region and 43 amino acids from the N-terminus of full-length KLK7. The histidine which is part of the catalytic triad is also omitted which would result in a proteolytic inactive protein. The presence of this isoform has not yet been confirmed in human tissues or biological fluids.
Expression Full-length KLK7 protein was originally purified in human skin and named stratum corneum chymotryptic enzyme (SCCE, hSCCE). KLK7 cDNA was originally isolated from a keratinocyte derived library and designated PRSS6. Although Northern blot analyses have shown that KLK7 mRNA is predominantly localised to skin and pancreas, more sensitive RT-PCR experiments have shown that brain, kidney, ovary, bone, breast, endometrium, spinal cord, lung, prostate tissue and salivary tissue express KLK7 mRNA at low to modest levels. High KLK7 mRNA has been detected in malignancies of ovary, breast, lung and brain.
KLK7 protein has been detected by ELISA in a wide range of tissues at low (adrenal, bladder, cervix, fallopian tube, kidney, lung, lymph node, muscle, ovary, salivary gland, small intestine, spinal cord, spleen, thyroid gland, tonsil, trachea and vagina) to high (oesophagus, heart, liver and skin) levels. Modest levels of KLK7 protein have also been detected in human body fluid, such as, seminal plasma, breast milk, ovarian cancer ascites, salivary and cervicovaginal fluid.
In normal skin, KLK7 is expressed in late epidermal differentiation and found at all sites of epithelial cornification. Consequently, KLK7 is used as a marker for terminal epidermal differentiation. In normal epidermis, KLK7 was detected in a population of dendritic cells and in high suprabasal keratinocytes. KLK7 was also found in reconstructed human epidermis and its expression was suppressed by retinoic acid. An increased expression of KLK7 was found in suprabasal cells in orthokeratotic and parakeratotic areas of the lesions of oral lichen planus (an inflammatory disease) and benign oral keratosis (a non-inflammatory disease).
High KLK7 protein levels have been detected in the tissues of lung, breast, ovarian and squamous cervical cancers, oral squamous cell carcinoma and cervical adenocarcinoma tissues from patients. However, KLK7 is down regulated in cancerous prostate tissues compared to normal prostate tissues. KLK7, along with KLK6 and KLK10, is decreased in cerebrospinal fluid of frontotemporal dementia patients.
Localisation Full-length KLK7 is localised intracellularly in the cytoplasm prior to secretion. KLK7 protein is co-localised with KLK5 in skin and acinar cells of the pancreas by immunohistochemical staining.
The putative N-terminal truncated KLK7-181 isoform is potentially not secreted as it does not have a signal peptide, and cellular localisation remains to be determined.
Function To date, the major biological functions of KLK7 are associated with the skin and related epithelial tissues, such as hair follicles, oral mucosa and glandular lobules. KLK7 is involved in keratinization, stratum corneum formation, and turnover/desquamation of the skin through the degradation of cell adhesion glycoproteins, such as corneodesmosin, desmocollin 1 and plakoglobin. KLK7 has also been shown to cleave insulin B chain, degrade fibronectin, fibrinogen and interleukin 1beta (IL-1b), as well as activate pro-IL-1b. KLK7 and KLK5 can control activation of the human cathelicidin precursor protein, hCAP18, implying their ability to control innate immune defence.
An in vitro study showed that UVB radiation can increase KLK7 and KLK5 expression at both mRNA and protein levels in keratinocyte (HaCat) cells. In the epidermis, the major inhibitor of KLK7, antileukoprotease (secretory leukocyte protease inhibitor) is produced by keratinocytes and can inhibit detachment of corneocytes from human plantar callus in vitro, while a weaker KLK7 inhibitor, elafin (skin-derived antileukoprotease), can reduce the shedding of corneocytes. Established epidermal mouse models overexpressing KLK7 have been shown to develop chronic itchy dermatitis. Further characterisation of these models also revealed epidermal hyperproliferation, decreased skin barrier function, and decreased expression of MHC II antigen in keratinocytes. These data provide an in vivo pathophysiological foundation that KLK7 plays an important role in skin, such as listed those below.
KLK cascade activation systems have been described. KLK7 is activated by KLK5 and KLK12. KLK7 activates other members of the kallikrein-related peptidase family including KLK1, KLK2, prostate specific antigen (PSA/KLK3) and KLK9.
The function of the putative N-terminal truncated KLK7 remains to be established.
Homology At the protein level, KLK7 shares 28% (KLK12), 33% (KLK9), 36% (KLK10, 11), 37% (KLK1, KLK3/PSA), 38% (KLK2, KLK5, KLK6, KLK13), 40% (KLK8), 41% (KLK14), 43% (KLK4) and 42.6% (KLK15) sequence homology with other members of the kallikrein-related peptidase family.

Mutations

Germinal An AACC insertion in the 3'UTR of the KLK7 gene has been found, which altered the common allele AACC to the rare allele AACCAACC. This insertion was found to be associated with atopic dermatitis.

Implicated in

Note
  
Entity Endocrine related cancers
Disease It has been postulated that KLK7 plays a role in endocrine related cancers given its (a) dysregulated expression in cancerous tissues compared to normal tissues, (b) regulation by hormones, such as, oestradiol, progestins and glucocorticoids and (c) potential roles in degradation of cell-cell adhesion proteins, extracellular matrix (ECM) proteins and activation of other proteases and growth factors.
  
  
Entity Epithelial ovarian carcinoma (EOC)
Disease Kallikrein 7 is highly expressed in serous EOC at both the mRNA and protein levels, and high KLK7 mRNA expression is associated with poorly differentiated, late clinical stage ovarian carcinomas and the volume of residual tumour after surgery. Upregulated KLK7 protein was detected in EOC patient sera and tumour cytosols using ELISA, and in EOC tissue sections using immunohistochemistry and a quantitative automated in situ immunofluorescence-based protein analysis. At the mRNA level, both KLK7 and its exon 1 deleted short KLK7 transcripts were detected in serous EOC cells, while none or only KLK7 short transcript was found in normal ovarian epithelial cells. In addition, a coordinated expression pattern and co-localisation of KLK7 and KLK5 were found in serous EOC cells suggesting a proteolytic cascade between them. Co-overexpression of KLK4, KLK5, KLK6 and KLK7 in ovarian cancer cells (OV-MZ-6) led to increased invasion in vitro and resulted in increased tumour burden in nude mice. A coordinated expression of KLK7 and protease inhibitor antileukoprotease was also found in EOC cells. Of interest, the 110-139 amino acid region of the KLK7 protein incorporates multiple CD8+ CTL and CD4+ helper T cell epitopes, and represents an attractive target antigen for immunotherapy of ovarian cancer.
Prognosis EOC patients with KLK7 mRNA or protein expression in their tumours had a significantly shorter disease-free survival time than those with KLK7 negative tumours. KLK7 is an independent unfavourable predictor of disease-free and overall survival for patients with low grade cancers. KLK7 has been shown to increase specificity for diagnosis and prognosis of EOC in conjunction with other biomarkers, such as CA125, HE4 and B7-H4.
  
  
Entity Breast cancer
Disease KLK7 gene expression was significantly lower in tumour tissues from early stage (I/II) breast cancer patients and tumour cells with progesterone receptors.
Prognosis Two groups have reported conflicting data regarding the prognoses for breast cancer patients and KLK7 expressing tumours. One study found that breast cancer patients with KLK7 positive tumours have relatively shorter disease-free survival and overall survival than patients with KLK7 negative tumours. However, another study reported that breast cancer patients with KLK7 expressing tumours have favourable outcomes compared to those with KLK7 negative tumours.
  
  
Entity Cervical cancer
Disease In a study of 18 cervical cancer cell lines (10 primary and 8 established cell lines) and 8 normal cervical keratinocyte cell lines, KLK7 mRNA expression was detected in the cancer cells (5/10 primary and 4/8 established lines) but not in any of the normal cervical keratinocytes. Interestingly, all five patients, who harbour KLK7 positive tumours that were used to establish the primary cell lines, were found to have metastatic involvement of the pelvic tumour draining lymph nodes. In the same study, tumour restricted expression of KLK7 was confirmed by immunohistochemistry staining in 4 of the 5 primary squamous cervical tumours, and 1 of the 4 primary adenocarcinomas, but none of the normal cervical epithelial cells. Another immunohistochemical study showed a significantly higher expression of KLK7 in cervical adenocarcinomas compared to normal endocervical glands.
  
  
Entity Pancreatic cancer
Disease KLK7 is expressed in normal pancreas at mRNA and protein levels, and KLK7 protein is localised in acinar cells of the pancreas by immunohistochemical staining. KLK7 is overexpressed in pancreatic adenocarcinomas at both the mRNA and protein levels. KLK7 expression was also observed in neoplastic cells of all tumours examined using immunohistochemistry with moderate-to-intense staining in 16 of the 23 tumours examined. Only 2 of the 13 nonmalignant tissue specimens displayed moderate KLK7 staining, whereas the remaining specimens showed weak immunoreactivity. In pancreatic cancer cells, KLK7 was shown to i) cleave desmoglein 2, ii) cleave E-cadherin and the ECM protein, fibronectin, iii) enhance urokinase-type plasminogen activator receptor shedding, and iv) reduce cell aggregation and adhesion to vitronectin to promote pancreatic cancer invasion.
  
  
Entity Oral squamous cell carcinoma (OSCC)
Disease cDNA microarray analysis revealed that KLK5, KLK7, KLK8 and KLK10 were upregulated in tumour samples versus normal controls. RT-qPCR analysis confirmed that KLK7 mRNA was most differentially regulated with a 5.3-fold increase, while 2.8-, 4.0- and 3.5-fold increases were observed for KLK5, KLK8, and KLK10, respectively. Immunohistochemical analysis demonstrated strong reactivity for all 4 KLK proteins in both orthotopic murine tumours and human OSCC tissues.
  
  
Entity Lung cancer
Disease KLK7 mRNA levels are decreased in adenocarcinoma compared to matched nonmalignant lung tissue. Similarly, sera of patients with non-small cell lung cancer (NSCLC) have lower protein levels of KLK7, KLK5, KLK8, KLK10 and KLK12 than those from normal subjects. However, a study has reported intense cytoplasmic staining for KLK7, KLK5, KLK6 and KLK8 in 40-90% of squamous cell carcinomas, small cell carcinomas and carcinoid tumours while 20% of tumour cells had intense nuclear staining for KLK7, KLK5 and KLK8.
  
  
Entity Brain tumours
Disease RT-qPCR analysis showed that KLK7 mRNA expression in intracranial tumours was associated with shorter overall survival than those tumours with no KLK7 expression from a survival analysis study of 73 patients with intracranial tumours. Overexpression of KLK7 protein by cultivated brain tumour cells significantly enhanced the invasive potential in a Matrigel invasion assay.
  
  
Entity Colon cancer
Disease One study using a semi-quantitative RT-PCR method showed that the KLK7 gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients.
  
  
Entity Skin disorders
Note A majority of studies have concentrated on the concomitant functions of KLK7 and KLK5 in normal human skin and a number of skin disorders given its (a) high expression in pathological conditions compared to normal skin samples, (b) cleavage/degradation of intercellular adhesive glycoproteins and (c) potential of activation and degradation of cytokines, such as interleukin 1beta (IL-1b).
  
  
Entity Netherton syndrome (NS)
Disease NS is a rare but severe inherited disorder that presents the three following characteristics with varying degrees of severity of their symptoms. 1) Ichthyosiform erythroderma - inflamed, red, scaly skin and trichorrhexis invaginata ("bamboo hair"). 2) Short, brittle, lustreless hair and atopic diathesis. 3) Predisposition to allergy problems.
NS patients have mutations in the serine protease inhibitor Kazal-type 5 (SPINK5) gene, encoding the protease inhibitor LEKTI (lympho-epithelial Kazal-type related inhibitor). Early studies using mouse models revealed that SPINK5-deficient mice mimic NS through degradation of desmoglein 1 by epidermal protease. The pathophysiological processes in the skin and epithelial related tissues of NS patients result from the lack of functional LEKTI protease inhibitor and consequently the over-degradation of corneodesmosomal cadherins by KLK7, KLK5 and KLK14.
The SPINK5 gene is localised chromosome 5. SPINK5 mutations introduce premature termination codons in LEKTI transcripts and lead to the production of truncated LEKTI forms that lack several inhibitory domains. NS is an autosomal recessive condition.
  
  
Entity Atopic dermatitis (AD)
Disease AD is a chronic inflammatory and allergic skin disorder. Multifactorial studies have suggested that both genetic and environmental factors contribute to AD development. A study comprising 103 AD patients and 261 matched controls revealed a significant association between the rare AACCAACC allele in the 3'UTR of KLK7 with AD. However, another group found that the AACCAACC allele was not associated with AD in a cohort of 99 patients and 189 controls. Nevertheless, patients with the AACCAACC allele have increased KLK7 protease activity resulting in premature breakdown of corneodesmosomes, and leading to impairment of the epidermal barrier. Furthermore, acute eczematous lesions and clinically unaffected skin can further increase production of KLK7 and epidermal barrier functions are damaged through environmental interactions, such as washing with soap and detergents, or long-term application of corticosteroids. A combination of the above factors leads to a defective skin barrier and increases the risk of allergen penetration and succeeding inflammatory reaction. By ELISA, KLK7 levels were found to be elevated in the stratum corneum of AD patients, and KLK7 in the serum significantly correlated with eosinophil counts in the blood of AD patients, indicative of the body under an allergic condition.
  
  
Entity Psoriasis
Disease A number of early studies reported that the chymotrypsin-like activity in stratum corneum was slightly elevated in psoriasis, but KLK7 serum levels did not differ between normal volunteers and patients with psoriasis. It has been confirmed that KLK7 protein levels were similar between non-lesional and lesional skin extracts, but increased amounts of desmoglein 1, plakoglobin and high molecular weight fragments of desmocollin 1 were detected in the lesional skin, suggesting an involvement of other proteases.
  

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Oikonomopoulou K, Li L, Zheng Y, Simon I, Wolfert RL, Valik D, Nekulova M, Simickova M, Frgala T, Diamandis EP.
Br J Cancer. 2008 Oct 7;99(7):1103-13. Epub 2008 Sep 2.
PMID 18766180
 
Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer.
Pampalakis G, Sotiropoulou G.
Biochim Biophys Acta. 2007 Sep;1776(1):22-31. Epub 2007 Jun 14. (REVIEW)
PMID 17629406
 
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.
Pettus JR, Johnson JJ, Shi Z, Davis JW, Koblinski J, Ghosh S, Liu Y, Ravosa MJ, Frazier S, Stack MS.
Histol Histopathol. 2009 Feb;24(2):197-207.
PMID 19085836
 
A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma.
Planque C, Li L, Zheng Y, Soosaipillai A, Reckamp K, Chia D, Diamandis EP, Goodglick L.
Clin Cancer Res. 2008 Mar 1;14(5):1355-62.
PMID 18316555
 
KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
Planque C, de Monte M, Guyetant S, Rollin J, Desmazes C, Panel V, Lemarie E, Courty Y.
Biochem Biophys Res Commun. 2005 Apr 22;329(4):1260-6.
PMID 15766562
 
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells.
Prezas P, Arlt MJ, Viktorov P, Soosaipillai A, Holzscheiter L, Schmitt M, Talieri M, Diamandis EP, Kruger A, Magdolen V.
Biol Chem. 2006 Jun;387(6):807-11.
PMID 16800744
 
The role of human tissue kallikreins 7 and 8 in intracranial malignancies.
Prezas P, Scorilas A, Yfanti C, Viktorov P, Agnanti N, Diamandis E, Talieri M.
Biol Chem. 2006 Dec;387(12):1607-12.
PMID 17132107
 
Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression.
Psyrri A, Kountourakis P, Scorilas A, Markakis S, Camp R, Kowalski D, Diamandis EP, Dimopoulos MA.
Ann Oncol. 2008 Jul;19(7):1271-7. Epub 2008 Mar 5.
PMID 18325919
 
The extracellular matrix protein fibronectin is a substrate for kallikrein 7.
Ramani VC, Haun RS.
Biochem Biophys Res Commun. 2008 May 16;369(4):1169-73. Epub 2008 Mar 14.
PMID 18343220
 
The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells.
Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, Roman JJ, Anfossi S, O'Brien T, Pecorelli S.
Gynecol Oncol. 2004 Aug;94(2):283-8.
PMID 15297163
 
Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI).
Schechter NM, Choi EJ, Wang ZM, Hanakawa Y, Stanley JR, Kang Y, Clayman GL, Jayakumar A.
Biol Chem. 2005 Nov;386(11):1173-84.
PMID 16307483
 
Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols.
Shan SJ, Scorilas A, Katsaros D, Rigault de la Longrais I, Massobrio M, Diamandis EP.
Clin Chem. 2006 Oct;52(10):1879-86. Epub 2006 Aug 17.
PMID 16916986
 
Distribution of 15 human kallikreins in tissues and biological fluids.
Shaw JL, Diamandis EP.
Clin Chem. 2007 Aug;53(8):1423-32. Epub 2007 Jun 15.
PMID 17573418
 
Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors.
Shigemasa K, Tanimoto H, Underwood LJ, Parmley TH, Arihiro K, Ohama K, O'Brien TJ.
Int J Gynecol Cancer. 2001 Nov-Dec;11(6):454-61.
PMID 11906548
 
Alterations in the desquamation-related proteolytic cleavage of corneodesmosin and other corneodesmosomal proteins in psoriatic lesional epidermis.
Simon M, Tazi-Ahnini R, Jonca N, Caubet C, Cork MJ, Serre G.
Br J Dermatol. 2008 Jul;159(1):77-85. Epub 2008 Jul 1.
PMID 18460028
 
Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma.
Singh J, Naran A, Misso NL, Rigby PJ, Thompson PJ, Bhoola KD.
Int Immunopharmacol. 2008 Feb;8(2):300-6. Epub 2007 Sep 6.
PMID 18182244
 
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.
Skytt A, Stromqvist M, Egelrud T.
Biochem Biophys Res Commun. 1995 Jun 15;211(2):586-9.
PMID 7794273
 
Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa.
Sondell B, Dyberg P, Anneroth GK, Ostman PO, Egelrud T.
Acta Derm Venereol. 1996 May;76(3):177-81.
PMID 8800294
 
In situ evidence that the population of Langerhans cells in normal human epidermis may be heterogeneous.
Sondell B, Jonsson M, Dyberg P, Egelrud T.
Br J Dermatol. 1997 May;136(5):687-93.
PMID 9205500
 
Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies.
Sondell B, Thornell LE, Egelrud T.
J Invest Dermatol. 1995 May;104(5):819-23.
PMID 7537777
 
Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma.
Talieri M, Diamandis EP, Gourgiotis D, Mathioudaki K, Scorilas A.
Thromb Haemost. 2004 Jan;91(1):180-6.
PMID 14691584
 
Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer.
Talieri M, Mathioudaki K, Prezas P, Alexopoulou DK, Diamandis EP, Xynopoulos D, Ardavanis A, Arnogiannaki N, Scorilas A.
Thromb Haemost. 2009 Apr;101(4):741-7.
PMID 19350120
 
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
Tan OL, Whitbread AK, Clements JA, Dong Y.
Biol Chem. 2006 Jun;387(6):697-705. (REVIEW)
PMID 16800730
 
The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells.
Tanimoto H, Underwood LJ, Shigemasa K, Yan Yan MS, Clarke J, Parmley TH, O'Brien TJ.
Cancer. 1999 Nov 15;86(10):2074-82.
PMID 10570434
 
Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas.
Tian X, Shigemasa K, Hirata E, Gu L, Uebaba Y, Nagai N, O'Brien TJ, Ohama K.
Oncol Rep. 2004 Nov;12(5):1001-6.
PMID 15492784
 
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R.
J Invest Dermatol. 2004 Jul;123(1):62-6.
PMID 15191543
 
Ovarian cancer, the coagulation pathway, and inflammation.
Wang X, Wang E, Kavanagh JJ, Freedman RS.
J Transl Med. 2005 Jun 21;3:25.
PMID 15969748
 
Water modulation of stratum corneum chymotryptic enzyme activity and desquamation.
Watkinson A, Harding C, Moore A, Coan P.
Arch Dermatol Res. 2001 Sep;293(9):470-6.
PMID 11758790
 
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.
Weidinger S, Baurecht H, Wagenpfeil S, Henderson J, Novak N, Sandilands A, Chen H, Rodriguez E, O'Regan GM, Watson R, Liao H, Zhao Y, Barker JN, Allen M, Reynolds N, Meggitt S, Northstone K, Smith GD, Strobl C, Stahl C, Kneib T, Klopp N, Bieber T, Behrendt H, Palmer CN, Wichmann HE, Ring J, Illig T, McLean WH, Irvine AD.
J Allergy Clin Immunol. 2008 Sep;122(3):560-8.e4.
PMID 18774391
 
Expression of the serine protease kallikrein 7 and its inhibitor antileukoprotease is decreased in prostate cancer.
Xuan Q, Yang X, Mo L, Huang F, Pang Y, Qin M, Chen Z, He M, Wang Q, Mo ZN.
Arch Pathol Lab Med. 2008 Nov;132(11):1796-801.
PMID 18976018
 
Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.
Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, Schechter NM, Bonnart C, Descargues P, Hovnanian A, Gallo RL.
FASEB J. 2006 Oct;20(12):2068-80.
PMID 17012259
 
Activation profiles and regulatory cascades of the human kallikrein-related peptidases.
Yoon H, Laxmikanthan G, Lee J, Blaber SI, Rodriguez A, Kogot JM, Scarisbrick IA, Blaber M.
J Biol Chem. 2007 Nov 2;282(44):31852-64. Epub 2007 Sep 6.
PMID 17823117
 
Parallel overexpression of seven kallikrein genes in ovarian cancer.
Yousef GM, Polymeris ME, Yacoub GM, Scorilas A, Soosaipillai A, Popalis C, Fracchioli S, Katsaros D, Diamandis EP.
Cancer Res. 2003 May 1;63(9):2223-7.
PMID 12727843
 
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation.
Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP.
Gene. 2000 Aug 22;254(1-2):119-28.
PMID 10974542
 
Cloning and expression of the gene of chymotrypsin-like protease of human kallikrein-7 in Escherichia coli and isolation of recombinant protein.
Zakabunin AI, Mishukova OV, Khrapov EA, Sergeichev DS, Boiarskikh UA, Sverdlov ED, Filipenko ML.
Mol Gen Mikrobiol Virusol. 2007;(2):21-5.
PMID 17598454
 

Citation

This paper should be referenced as such :
Dong, Y ; Lai, J ; Clements, JA
KLK7 (kallikrein-related peptidase 7)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(4):389-396.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/KLK7ID41087ch19q13.html


External links

Nomenclature
HGNC (Hugo)KLK7   6368
Cards
AtlasKLK7ID41087ch19q13
Entrez_Gene (NCBI)KLK7  5650  kallikrein related peptidase 7
AliasesPRSS6; SCCE; hK7
GeneCards (Weizmann)KLK7
Ensembl hg19 (Hinxton)ENSG00000169035 [Gene_View]  chr19:51479735-51487320 [Contig_View]  KLK7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169035 [Gene_View]  chr19:51479735-51487320 [Contig_View]  KLK7 [Vega]
ICGC DataPortalENSG00000169035
TCGA cBioPortalKLK7
AceView (NCBI)KLK7
Genatlas (Paris)KLK7
WikiGenes5650
SOURCE (Princeton)KLK7
Genetics Home Reference (NIH)KLK7
Genomic and cartography
GoldenPath hg19 (UCSC)KLK7  -     chr19:51479735-51487320 -  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLK7  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblKLK7 - 19q13.33 [CytoView hg19]  KLK7 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIKLK7 [Mapview hg19]  KLK7 [Mapview hg38]
OMIM604438   
Gene and transcription
Genbank (Entrez)AA101043 AF411214 AF411215 AI049783 AK289660
RefSeq transcript (Entrez)NM_001207053 NM_001243126 NM_005046 NM_139277
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)KLK7
Cluster EST : UnigeneHs.151254 [ NCBI ]
CGAP (NCI)Hs.151254
Alternative Splicing GalleryENSG00000169035
Gene ExpressionKLK7 [ NCBI-GEO ]   KLK7 [ EBI - ARRAY_EXPRESS ]   KLK7 [ SEEK ]   KLK7 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5650
GTEX Portal (Tissue expression)KLK7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49862   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49862  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49862
Splice isoforms : SwissVarP49862
Catalytic activity : Enzyme3.4.21.117 [ Enzyme-Expasy ]   3.4.21.1173.4.21.117 [ IntEnz-EBI ]   3.4.21.117 [ BRENDA ]   3.4.21.117 [ KEGG ]   
PhosPhoSitePlusP49862
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLK7
DMDM Disease mutations5650
Blocks (Seattle)KLK7
PDB (SRS)2QXG    2QXH    2QXI    2QXJ    3BSQ   
PDB (PDBSum)2QXG    2QXH    2QXI    2QXJ    3BSQ   
PDB (IMB)2QXG    2QXH    2QXI    2QXJ    3BSQ   
PDB (RSDB)2QXG    2QXH    2QXI    2QXJ    3BSQ   
Structural Biology KnowledgeBase2QXG    2QXH    2QXI    2QXJ    3BSQ   
SCOP (Structural Classification of Proteins)2QXG    2QXH    2QXI    2QXJ    3BSQ   
CATH (Classification of proteins structures)2QXG    2QXH    2QXI    2QXJ    3BSQ   
SuperfamilyP49862
Human Protein AtlasENSG00000169035
Peptide AtlasP49862
HPRD05115
IPIIPI00028600   IPI00556124   IPI01017883   IPI00455000   
Protein Interaction databases
DIP (DOE-UCLA)P49862
IntAct (EBI)P49862
FunCoupENSG00000169035
BioGRIDKLK7
STRING (EMBL)KLK7
ZODIACKLK7
Ontologies - Pathways
QuickGOP49862
Ontology : AmiGOpositive regulation of antibacterial peptide production  metalloendopeptidase activity  serine-type endopeptidase activity  extracellular region  extracellular space  proteolysis  peptidase activity  serine-type peptidase activity  epidermis development  extracellular matrix disassembly  epidermal lamellar body  
Ontology : EGO-EBIpositive regulation of antibacterial peptide production  metalloendopeptidase activity  serine-type endopeptidase activity  extracellular region  extracellular space  proteolysis  peptidase activity  serine-type peptidase activity  epidermis development  extracellular matrix disassembly  epidermal lamellar body  
REACTOMEP49862 [protein]
REACTOME Pathways1474228 [pathway]   
NDEx NetworkKLK7
Atlas of Cancer Signalling NetworkKLK7
Wikipedia pathwaysKLK7
Orthology - Evolution
OrthoDB5650
GeneTree (enSembl)ENSG00000169035
Phylogenetic Trees/Animal Genes : TreeFamKLK7
HOVERGENP49862
HOGENOMP49862
Homologs : HomoloGeneKLK7
Homology/Alignments : Family Browser (UCSC)KLK7
Gene fusions - Rearrangements
Fusion : MitelmanKDM4C/KLK7 [9p24.1/19q13.41]  [t(9;19)(p24;q13)]  
Fusion: TCGAKDM4C 9p24.1 KLK7 19q13.41 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK7
dbVarKLK7
ClinVarKLK7
1000_GenomesKLK7 
Exome Variant ServerKLK7
ExAC (Exome Aggregation Consortium)KLK7 (select the gene name)
Genetic variants : HAPMAP5650
Genomic Variants (DGV)KLK7 [DGVbeta]
DECIPHER (Syndromes)19:51479735-51487320  ENSG00000169035
CONAN: Copy Number AnalysisKLK7 
Mutations
ICGC Data PortalKLK7 
TCGA Data PortalKLK7 
Broad Tumor PortalKLK7
OASIS PortalKLK7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLK7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLK7
DgiDB (Drug Gene Interaction Database)KLK7
DoCM (Curated mutations)KLK7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLK7 (select a term)
intoGenKLK7
NCG5 (London)KLK7
Cancer3DKLK7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604438   
Orphanet
MedgenKLK7
Genetic Testing Registry KLK7
NextProtP49862 [Medical]
TSGene5650
GENETestsKLK7
Huge Navigator KLK7 [HugePedia]
snp3D : Map Gene to Disease5650
BioCentury BCIQKLK7
ClinGenKLK7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5650
Chemical/Pharm GKB GenePA30157
Clinical trialKLK7
Miscellaneous
canSAR (ICR)KLK7 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLK7
EVEXKLK7
GoPubMedKLK7
iHOPKLK7
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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