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PIMREG (PICALM interacting mitotic regulator)

Written2017-01Leticia Fröhlich Archangelo
Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Abstract PIMREG (FAM64) was initially identified as CATS, the CALM (PICALM) interacting protein expressed in thymus and spleen. Mounting evidence suggests the involvement of FAM64A in tumorigenesis. Through interaction with PICALM, FAM64 was able to influence the subcellular localization of the leukemic fusion protein PICALM/MTT10 (CALM/AF10). FAM64A is highly expressed in leukemia, lymphoma and tumor cell lines and its levels are strongly correlated with cellular proliferation in both malignant and normal cells. FAM64A is a mitotic regulator that controls chromosome segregation during cell division, and its transcripts covariate with that of cell cycle regulation genes in tumorigenesis. Nevertheless, a precise role of FAM64A in tumorigenesis is yet to be defined.

Keywords PIMREG; FAM64; chromosome 17; proliferation; tumorigeneses; metaphase-anaphase transition; cell-cycle control; PICALM/MTT10

(Note : for Links provided by Atlas : click)


family with sequence similarity 64
Alias_symbol (synonym)FLJ10156
Other aliasFAM64A
LocusID (NCBI) 54478
Atlas_Id 54310
Location 17q13.2  [Link to chromosome band 17q13]
Location_base_pair Starts at 6347735 and ends at 6354385 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)


  Figure 1: Genomic organization, alternative splicing, and protein isoforms of PIMREG (FAM64). Boxes represent exons, with blue parts symbolizing coding region and gray parts the 5' and 3' UTRs. There are 2 splice variants (sizes are indicated in parentheses). In splice variant 2, exon 5 is spliced out resulting in a longer protein (FAM64A isoform 2) encoded by exons 2, 3, 4 and 6. The FAM64A isoform 1 (shorter form) is encoded by exons 2, 3, 4 and 5 from splice variants 1 and the transcript with retained intron 5 (see in the text). Both FAM64A isoforms are identical from amino acids 1-228, they differ in their last 10 and 20 C-terminal residues (isoform 1 and 2, respectively). (Figure modified from Archangelo, et al. 2006)
Description PIMREG (FAM64) is located on chromosome 17 band p13.2, 6.29 megabase pairs from the telomere of the short arm (chromosome 17 genomic contig NT_010718). The genomic locus spans 7 Kb and contains 6 exons with a non-coding first exon.
Transcription Two alternatively spliced transcripts of 1.5 Kb are formed (NM_019013 and NM_001195228) and code for two protein isoforms of 238 and 248 amino acids in length (isoform 1 and 2, respectively). Both isoforms share the first 228 residues, encoded by exons 2-4. The two proteins differ in their C-termini. The 10 last amino acids of isoform 1 are encoded by exon 5, which is absent in the transcript coding for isoform 2. The last 20 amino acids of isoform 2 are encoded by exon 6 (Figure 1) (Archangelo, et al. 2006). An additional transcript variant with retained intron 5 (between exons 5 and 6) was described (Archangelo, et al. 2006; Coulombe-Huntington, et al. 2009). There are 4 processed pseudogenes of FAM64A at other chromosomal locations (2q33, 4p15, 4q24 and 6q15).


  Figure 2: Diagram representing the protein structure of PIMREG (FAM64). FAM64A is a phosphoprotein. All residues described to be phosphorylated in large scale proteomic studies are depicted. Source: Phosphoproteomic databases PhosphoSitePlus™ ( and Phosida ( Destruction box motifs are depicted as orange boxes (DB1 and DB2). Aminoacids comprising the DB motifs and the unique phospho-residue characterized (S131) are shown. (Figure modified from Archangelo, et al. 2013)
Description The FAM64A calculated molecular weight is about 27 kDa. The protein contains two putative destruction box motifs (RxxL) at amino acids 14-17 and 53-56 (DB1 and DB2, respectively), the second being a recognition motif for the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) (Zhao, et al. 2008). There are three types of posttranslational modifications identified within FAM64A isoforms, namely lysine- acetylation (K-ac), lysine-ubiquitination (K-ub) and phosphorylation (S-p and T-p). A total of 22 residues were described as phosphorylated in FAM64A in a variety of large scale proteomic studies as revealed by the phosphoproteomic databases PhosphoSitePlus™ ( and Phosida ( (Figure 2).
Expression In normal adult tissue FAM64A is predominantly expressed in thymus, spleen and colon and to a lesser extent in small intestines, ovary and brain (Archangelo, et al. 2006; Archangelo, et al. 2008). Moreover, FAM64A is highly expressed in leukemia, lymphoma and tumor cell lines. The protein levels vary throughout the cell cycle. In synchronized cells FAM64A accumulates in S and G2 phases of the cell cycle, peaks in the mitosis and drops drastically as cells exit from mitosis into the G1 phase (Archangelo, et al. 2008; Zhao, et al. 2008). FAM64A transcripts covariate with that of cell cycle regulation genes in tumorigenesis (Zhao, et al. 2008). Resting human peripheral blood lymphocytes (PBLs), which are not selected for growth in culture, do not express FAM64A protein. However, when these cells are induced to proliferate upon mitogen activation they do express FAM64A. Likewise, glioblastoma cells induced to proliferate, show a progressive upregulation of FAM64A. Conversely, FAM64A expression drastically decreases when highly proliferative leukemia cells cease to proliferate upon exposure to differentiation agents (Barbutti, et al. 2016).Thus, FAM64A expression positively correlates with the proliferative state of the cells (Archangelo, et al. 2008).
Expression analysis of the murine Fam64a homolog revealed a strong expression throughout mouse embryogenesis, in particular at the developing central nervous system (CNS). The expression decreases gradually and proportionally as embryos develop to later stages (Archangelo, et al. 2008). In the hematopoietic compartment, Fam64A is widely expressed in different cell subpopulations (Archangelo, et al. 2008). Moreover, RNA-Seq analysis of individual hematopoietic stem cells (HSCs) to resolve heterogeneity within HSC population, revealed that Fam64a is highly expressed in the HSC population primed for proliferation (Wilson, et al. 2015).
Localisation FAM64A is a nuclear protein enriched in the nucleoli. Expression levels in the nucleoplasm and nucleolar accumulation are different from cell to cell and dependent on the cell cycle phase (Archangelo, et al. 2008) (Figure 3). In mitotic cells FAM64A-GFP is diffusely distributed throughout cells without specific association with chromosomes, kinetochores, spindle, or centrosome (Zhao, et al. 2008).
  Figure 3: Subcellular localization of endogenous PIMREG (FAM64). Endogenous protein was visualized by immunofluorescence and confocal microscopy in non-synchronized U2OS cells. FAM64A is a nuclear protein enriched in the nucleolus of some cells. Note the different levels of FAM64A expression from cell to cell. FAM64A protein levels and nucleolar localization are cell cycle dependent. The figure shows cells labeled with Cy3 (FAM64A) and DAPI with channels merged.
Function Based on the fact that levels of FAM64A protein strongly correlate with cellular proliferation in both normal and malignant cells, this protein was described as a marker for proliferation with a possible role in the control of cell proliferation and tumorigenesis (Archangelo, et al. 2008). In fact, silencing of FAM64A protein in the U937 leukemia cell line resulted in reduced proliferation and altered cell cycle progression, as attested by diminished expression of the cell cycle regulators CCNA1, CCNE1, CCNB1 (cyclin-A, -E and -B1) in FAM64A depleted cells (Barbutti, et al. 2016).
Furthermore, Zhao and coworkers described FAM64A as a regulator of chromosome segregation. FAM64A is a substrate of the APC/C complex that controls the metaphase to anaphase transition and its knock-down resulted in accelerated anaphase onset. Thus FAM64A plays an important role in determining the kinetics of mitotic progression (Zhao, et al. 2008). Although the literature indicates a putative function of FAM64A in controlling cell cycle progression, division and tumorigenesis, the impairment of cell proliferation upon FAM64A depletion was modest and not sufficient to inhibit tumor growth of xenotransplanted U937 cells in an in vivo model (Barbutti, et al. 2016). Similarly, the faster metaphase-to-anaphase transition observed in FAM64A depleted cells was not sufficient to produce any of the mitotic defects often observed in cancer cells. Rather, mitotic index, spindle assembly, chromosome congregation/segregation and cytokinesis proceeded normally in FAM64A depleted cells (Zhao, et al. 2008).
FAM64A has also been described to function as a transcriptional repressor in a GAL4-based reporter gene assay (Archangelo, et al. 2006). Additionally, FAM64A was able to repress the transactivation capacity of the leukemic fusion protein PICALM/MTT10 (CALM/AF10) (Archangelo, et al. 2013). Evidence further supporting the transcriptional inhibitory properties of FAM64A were provided by Zhao and colleagues, who described the interaction between FAM64A and components of the nucleosome remodeling and deacetylase (NuRD) complex, such as MTA2, HDAC1/HDAC2 and RBBP7 / RBBP4 (RBAp46/48) (Zhao, et al. 2008). The NuRD complex is implicated in transcriptional regulation and plays a role in modifying chromatin structures to initiate and maintain gene repression.
Since its discovery a number of FAM64 interacting proteins have been described (e.g. PICALM (Archangelo, et al. 2006), UHMK1 (KIS) (Archangelo, et al. 2013), PRNP (PrPC) (Satoh, et al. 2009), PTBP3 (ROD1) (Brazao, et al. 2012) and NuRD complex (Zhao, et al. 2008), shedding light on the putative function of this protein.
The interaction of FAM64A with the Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) was identified in a yeast two hybrid screen (Y2H) and confirmed by GST pull-down and co-immunoprecipitation experiments for both FAM64A isoforms. The FAM64A interaction region was mapped to amino acids 221 to 294 of PICALM. Through this interaction FAM64A was able to alter the subcellular localization of PICALM. The fluorescently-tagged protein YFP-PICALM localized mainly in the cytoplasm and plasma membrane of transfected NIH3T3 cells. However, when CFP-FAM64A was co-expressed, PICALM was observed both at the cytoplasm/membrane and in the nucleus of some cells at almost equal levels (Archangelo, et al. 2006).
The interaction between FAM64A and the Kinase Interacting Stathmin (KIS and UHMK1) was identified in Y2H screen and confirmed by GST pull-down, co-immunoprecipitation and co-localization experiments. KIS interacts with amino-acids 136-187 of FAM64A. Kinase assay showed that FAM64A is a substrate of KIS at serine 131 (S131). In a GAL4-based reporter gene assay KIS enhanced the transcriptional repressor activity of FAM64A, independently of phosphorylation on S131 but dependent on KIS kinase activity (Archangelo, et al. 2013).
RNA immunoprecipitation sequencing (RIP-seq) described the interaction between FAM64A and ROD1 (PTBP3), an RNA-binding protein involved in nonsense-mediated decay (NMD) (Brazao, et al. 2012).
Protein microarray analysis identified FAM64A as an interacting partner of the cellular prion protein (PrPC). The interaction was confirmed by co-immunoprecipitation of the overexpressed tagged-proteins (Satoh, et al. 2009).
Homology The human FAM64A shares homology with the species described in Table 1.
Table 1. Homology between the human FAM64A and other species
Homo sapiens FAM64ASymbolIdentity (%)
Protein DNA
vs. P.troglodytes FAM64A96.698.6
vs. vs. M. mulattaLOC712701 91.6 95.9
vs. C. lupusFAM64A73.381.2
vs. B. taurusFAM64A83.2 85.9
vs. M. musculusFam64a74.8 77.5
vs. R. norvegicusFam64a76.779.1



Somatic Mutations in the FAM64A gene were reported in the catalogue of somatic mutations in cancer (COSMIC) database in 53 out of the 28710 samples tested, of which 6 are nonsense substitutions, 33 missense substitutions and 10 synonymous substitutions (

Implicated in

Entity Leukemia
Note FAM64A is highly expressed in leukemia and lymphoma cell lines (Archangelo, et al. 2008). FAM64A interacts with the central domain of PICALM, a region contained in the PICALM moiety of the PICALM/MLLT10 (CALM/AF10) leukemic fusion protein (Archangelo, et al. 2006). FAM64A expression markedly increased the nuclear localization of PICALM/MLLT10 (CALM/AF10) and counteracted the ability of this fusion protein to activate transcription in vitro (Archangelo, et al. 2006; Archangelo, et al. 2013). Additionally, the murine Fam64a transcripts were up-regulated in hematopoietic cells (B220+ lymphoid cells) transformed by PICALM/MLLT10 (CALM/AF10) in comparison to the same subpopulation from non-leukemic mice (Archangelo, et al. 2008).
In a recent report, FAM64A silencing in the PICALM/MLLT10 (CALM/AF10)-positive U937 leukemia cell line resulted in somewhat reduced proliferation, altered cell cycle progression, lower migratory ability in vitro, and reduced clonogenicity of FAM64A-depleted U937 cells. Nonetheless, FAM64A silencing was not capable of interfering with the expression of the PICALM/MLLT10 (CALM/AF10)-leukemia deregulated genes (HOXA gene cluster, MEIS1 and BMI1) nor sufficient to hinder tumor growth of U937 xenografts (Barbutti, et al. 2016).
Entity Breast cancer
Note FAM64A was identified together with BIRC5 and CENPA as the three genes specifically upregulated in triple-negative breast cancer (TNBC), an aggressive type of cancer with poor outcome and short survival. In a broader clinical set analysis, FAM64A upregulation correlated with poor survival, despite the molecular type of breast cancer (Zhang, et al. 2014).
Entity Lung cancer
Note The fusion gene XAF1 (17p13.1) / FAM64A (17p13.2) was identified in a single lung adenocarcinoma patient from a large scale RNA sequencing study. The fusion gene was validated by Sanger sequencing and showed no co-occurrence with other canonical driver point mutation in that sample. The breakpoints were described at position chr17:6663920, within exon 4 of the donor transcript (XAF1), and at position chr17:6348396, within the 5' untranslated region (5'UTR) of the acceptor gene FAM64A (Seo, et al. 2012).
In the same study FAM64A was also detected among a number of cancer outlier genes (CoGs), being highly expressed in 8 cancer tissue samples (Seo, et al. 2012).
Entity Head and Neck squamous cell carcinoma
Note Single gene clustering of RNA sequencing in a set of 177 lung and 279 head and neck squamous cell carcinomas, reveled a differential alternative isoform usage pattern of the FAM64A locus, with lower expression of a 152 bp cluster within the final exon of the gene. The implication of the differential isoform usage remains to be determined (Kimes, et al. 2014).

To be noted

FAM64A is a marker for proliferation (Archangelo, et al. 2008) with potential use as a prognostic marker (Zhang, et al. 2014). FAM64A plays a role in the regulation of chromosome segregation during cell division (Zhao, et al. 2008) and in the control of cell cycle progression and clonogenicity of the U937 leukemia cell line (Barbutti, et al. 2016). However, FAM64A depletion is not sufficient to impair either mitosis or hinder cell growth (Barbutti, et al. 2016; Zhao, et al. 2008). Hence, it still to be addressed whether the strong correlation of FAM64A expression with proliferation is determinant for tumorigenesis or if it is a consequence.


The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS)
Archangelo LF, Greif PA, Maucuer A, Manceau V, Koneru N, Bigarella CL, Niemann F, dos Santos MT, Kobarg J, Bohlander SK, Saad ST
Biochim Biophys Acta 2013 May;1833(5):1269-79
PMID 23419774
CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells
Barbutti I, Xavier-Ferrucio JM, Machado-Neto JA, Ricon L, Traina F, Bohlander SK, Saad ST, Archangelo LF
Oncotarget 2016 Oct 18;7(42):68385-68396
PMID 27588395
A new function of ROD1 in nonsense-mediated mRNA decay
Brazão TF, Demmers J, van IJcken W, Strouboulis J, Fornerod M, Romão L, Grosveld FG
FEBS Lett 2012 Apr 24;586(8):1101-10
PMID 22575643
Fine-scale variation and genetic determinants of alternative splicing across individuals
Coulombe-Huntington J, Lam KC, Dias C, Majewski J
PLoS Genet 2009 Dec;5(12):e1000766
PMID 20011102
SigFuge: single gene clustering of RNA-seq reveals differential isoform usage among cancer samples
Kimes PK, Cabanski CR, Wilkerson MD, Zhao N, Johnson AR, Perou CM, Makowski L, Maher CA, Liu Y, Marron JS, Hayes DN
Nucleic Acids Res 2014 Aug;42(14):e113
PMID 25030904
Protein microarray analysis identifies human cellular prion protein interactors
Satoh J, Obayashi S, Misawa T, Sumiyoshi K, Oosumi K, Tabunoki H
Neuropathol Appl Neurobiol 2009 Feb;35(1):16-35
PMID 18482256
The transcriptional landscape and mutational profile of lung adenocarcinoma
Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, Bleazard T, Lee J, Jung YJ, Kim JO, Shin JY, Yu SB, Kim J, Lee ER, Kang CH, Park IK, Rhee H, Lee SH, Kim JI, Kang JH, Kim YT
Genome Res 2012 Nov;22(11):2109-19
PMID 22975805
Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations
Wilson NK, Kent DG, Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B
Cell Stem Cell 2015 Jun 4;16(6):712-24
PMID 26004780
Integrated analysis of expression profiling data identifies three genes in correlation with poor prognosis of triple-negative breast cancer
Zhang C, Han Y, Huang H, Min L, Qu L, Shou C
Int J Oncol 2014 Jun;44(6):2025-33
PMID 24676531
RCS1, a substrate of APC/C, controls the metaphase to anaphase transition
Zhao WM, Coppinger JA, Seki A, Cheng XL, Yates JR 3rd, Fang G
Proc Natl Acad Sci U S A 2008 Sep 9;105(36):13415-20
PMID 18757745


This paper should be referenced as such :
Archangelo LF
PIMREG (PICALM interacting mitotic regulator);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma

External links

HGNC (Hugo)PIMREG   25483
Entrez_Gene (NCBI)PIMREG  54478  family with sequence similarity 64 member A
AliasesCATS; RCS1
GeneCards (Weizmann)PIMREG
Ensembl hg19 (Hinxton)ENSG00000129195 [Gene_View]  chr17:6347735-6354385 [Contig_View]  PIMREG [Vega]
Ensembl hg38 (Hinxton)ENSG00000129195 [Gene_View]  chr17:6347735-6354385 [Contig_View]  PIMREG [Vega]
ICGC DataPortalENSG00000129195
Genatlas (Paris)PIMREG
Genetics Home Reference (NIH)PIMREG
Genomic and cartography
GoldenPath hg19 (UCSC)PIMREG  -     chr17:6347735-6354385 +  17p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIMREG  -     17p13.2   [Description]    (hg38-Dec_2013)
EnsemblPIMREG - 17p13.2 [CytoView hg19]  PIMREG - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIPIMREG [Mapview hg19]  PIMREG [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK001018 AK001353 AK225613 AK225702 BC005004
RefSeq transcript (Entrez)NM_001195228 NM_019013
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)PIMREG
Cluster EST : UnigeneHs.592116 [ NCBI ]
CGAP (NCI)Hs.592116
Alternative Splicing GalleryENSG00000129195
Gene Expression Viewer (FireBrowse)PIMREG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54478
GTEX Portal (Tissue expression)PIMREG
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BSJ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BSJ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BSJ6
Splice isoforms : SwissVarQ9BSJ6
Domains : Interpro (EBI)DUF1466   
Domain families : Pfam (Sanger)DUF1466 (PF07326)   
Domain families : Pfam (NCBI)pfam07326   
Conserved Domain (NCBI)PIMREG
DMDM Disease mutations54478
Blocks (Seattle)PIMREG
Human Protein AtlasENSG00000129195
Peptide AtlasQ9BSJ6
IPIIPI00305430   IPI00149860   
Protein Interaction databases
IntAct (EBI)Q9BSJ6
Ontologies - Pathways
Ontology : AmiGOprotein binding  nucleus  nucleolus  cytoplasm  mitotic nuclear division  cell division  
Ontology : EGO-EBIprotein binding  nucleus  nucleolus  cytoplasm  mitotic nuclear division  cell division  
Atlas of Cancer Signalling NetworkPIMREG
Wikipedia pathwaysPIMREG
Orthology - Evolution
GeneTree (enSembl)ENSG00000129195
Phylogenetic Trees/Animal Genes : TreeFamPIMREG
Homologs : HomoloGenePIMREG
Homology/Alignments : Family Browser (UCSC)PIMREG
Gene fusions - Rearrangements
Fusion : MitelmanXAF1/FAM64A [17p13.1/17p13.2]  [t(17;17)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIMREG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIMREG
Exome Variant ServerPIMREG
ExAC (Exome Aggregation Consortium)PIMREG (select the gene name)
Genetic variants : HAPMAP54478
Genomic Variants (DGV)PIMREG [DGVbeta]
DECIPHER (Syndromes)17:6347735-6354385  ENSG00000129195
CONAN: Copy Number AnalysisPIMREG 
Broad Tumor PortalPIMREG
OASIS PortalPIMREG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIMREG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIMREG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIMREG
DgiDB (Drug Gene Interaction Database)PIMREG
DoCM (Curated mutations)PIMREG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIMREG (select a term)
Cancer3DPIMREG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry PIMREG
NextProtQ9BSJ6 [Medical]
Huge Navigator PIMREG [HugePedia]
snp3D : Map Gene to Disease54478
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54478
Chemical/Pharm GKB GenePA142671874
Clinical trialPIMREG
canSAR (ICR)PIMREG (select the gene name)
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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