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SIAH1 (siah E3 ubiquitin protein ligase 1)

Written2013-02Yoshito Nagano, Shu-Ichi Matsuzawa
Hiroshima University Graduate School of Biomedical, Health Sciences, Hiroshima 734-8551, Japan (YN), Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA (SIM)

(Note : for Links provided by Atlas : click)

Identity

Alias_namesseven in absentia homolog 1 (Drosophila)
Alias_symbol (synonym)hSIAH1
Other aliasSIAH1A
HGNC (Hugo) SIAH1
LocusID (NCBI) 6477
Atlas_Id 457
Location 16q12.1  [Link to chromosome band 16q12]
Location_base_pair Starts at 48360536 and ends at 48365873 bp from pter ( according to hg19-Feb_2009)  [Mapping SIAH1.png]
 
  Map of chromosome 16 with region 16q12.1 highlighted as the location of the gene SIAH1.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LONP2 (16q12.1) / SIAH1 (16q12.1)PCYT1B (Xp22.11) / SIAH1 (16q12.1)SIAH1 (16q12.1) / CREBBP (16p13.3)

DNA/RNA

Note The human Siah1 gene is composed of 2 exons, separated by an intron of roughly 14,5 kb.
 
  Genomic structure and exon-intron boundaries for SIAH1. The relevant DNA sequences at exon-intron boundaries are indicated, and respective amino acid sequences are indicated below in single-letter code. The entire open reading frame of SIAH1 is in exon 2, and its initiating methionine is underlined.
Pseudogene One pseudogene has been reported.

Protein

 
  Schema of Siah1 structure. Siah1 has RING domain at the N-terminus and the substrate binding domain (SBD) at the C-terminus. Some substrate proteins are recognized by this substrate binding domain directly, and receive ubiquitin-conjugation.
Expression Siah1 mRNA is widely expressed in the human tissues. It is expressed at higher level in placenta, skeletal muscle and testis.
Localisation Siah1 protein can be localized in both cytoplasm and nucleus.
Function Siah1 is the mammalian homolog of Drosophia seven in absentia (SINA) protein (Carthew and Rubin, 1990). Siah1 protein plays a key role in biological processes such as the cell cycle, programmed cell death, and oncogenesis (Nemani et al., 1996). The Siah family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Numerous substrates targeted for degradation by Siah proteins have been reported; Synphilin-1 (Nagano et al., 2003), DCC (Hu et al., 1997), N-CoR (Zhang et al., 1998), BOB1/OBF1 (Boehm et al., 2001, Tiedt et al., 2001), c-Myb (Tanikawa et al., 2000), Kid (Germani et al., 2000) and CtIP (Germani et al., 2003). Siah1 expression is upregulated by p53, revealing a link between genotoxic injury and destruction of β-catenin and reduced T-cell factor/lymphoid enhancer factor (Tcf/Lef) activity (Liu et al., 2001; Jansen et al., 2009). Recent paper showed Siah1 expression facilitates ubiquitination and degradation of the tumor suppressor HIPK2 that is a key regulator of the apoptotic programme induced by DNA damage (Winter et al., 2008).
It has been shown that the nuclear translocation and accumulation of GAPDH play important roles in early events leading to cell death initiation and execution (Sirover, 1999), resulting in the various degenerative diseases. Siah1 functions as a potential carrier/shuttle proteins for the induction of GAPDH nuclear translocation because of its nuclear location signal (NLS) domain in Siah1 (Hara et al., 2005).
Siah1a knockout mice are growth-retarded, exhibit early lethality, and display spermatogenetic defects. They also exhibit high numbers of osteoclasts with low numbers of osteoblasts, resulting in severe osteopenia (Frew et al., 2004).
Homology Human: Siah2.
Mouse: Siah1a, Siah1b, Siah2.

Mutations

Note There is limited evidence for mutation, with only one report of a low frequency of inactivating mutations in gastric cancer (Kim et al., 2004).

Implicated in

Note
  
Entity Breast cancer
Note Wen et al. showed that Siah1 overexpression induced cell apoptosis by up-regulating the level of Bim through the activation of the JNK signaling pathway, and the suppression of Siah1 expression increased cell invasion via the activation of the ERK signaling pathway in breast cancer cells (Wen et al., 2010a; Wen et al., 2010b).
He et al. showed that overexpression of Siah1 enhanced radiation-induced apoptosis in breast cancer cells (He et al., 2010).
Those data suggest that Siah1 can be a novel therapeutic target for tumor cell death.
  
  
Entity Leukemia
Note Krämer et al. showed that the leukemia fusion protein PML-RARα (promyelocytic leukemia-retinoic acid receptor α which causes acute promyelocytic leukemias, is degraded by ubiquitin-proteasome system and that their turnover critically depends on the E2-conjugase UbcH8 and Siah1. They also showed that HDAC inhibitor enhanced the degradation of leukemia fusion proteins via UbcH8-Siah1 axis and could be a new therapeutic strategy for leukemia (Krämer et al., 2008).
  
  
Entity Gastric cancer
Note Kim et al. found two missense mutations in the SIAH1 gene in gastric cancer. The two mutants revealed that impairment of β-catenin degradation pathway, increase of cyclin D1 expression, and inhibition of apoptosis in culture cells, suggesting that mutations of Siah1 gene may play an important role in the development and progression in a subset of gastric cancer through β-catenin stabilization and apoptosis block (Kim et al., 2004).
  
  
Entity Hepatocellular carcinoma
Note Matsuo et al. showed that the expression level of SIAH1 was markedly downregulated in hepatocellular carcinoma (HCC), especially in advanced stages (Matsuo et al., 2003). Okabe et al. showed that the paternally expressed gene 10 (PEG10) was an important factor in HCC progression as a substrate for Siah1 and could be a novel molecular target for treatment (Okabe et al., 2003).
  
  
Entity Parkinson's disease
Note Nagano et al. showed for the first time that Siah1 ubiquitinated α-synuclein-interacting protein, Synphilin-1, leading to degradation. These proteins are located in Lewy body, the pathological hallmark of Parkinson's disease (Nagano et al., 2003). Recent papers showed that Siah1 facilitated mono- or di-ubiquitination of α-synuclein, leading to Lewy body formation (Lee et al., 2008; Rott et al., 2008). But no mutation in Siah1 has been identified in Parkinson's disease patients (Franck et al., 2006).
  

Bibliography

 
Regulation of BOB.1/OBF.1 stability by SIAH.
Boehm J, He Y, Greiner A, Staudt L, Wirth T.
EMBO J. 2001 Aug 1;20(15):4153-62.
PMID 11483518
 
seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.
Carthew RW, Rubin GM.
Cell. 1990 Nov 2;63(3):561-77.
PMID 2146028
 
Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease.
Franck T, Krueger R, Woitalla D, Muller T, Engelender S, Riess O.
J Neural Transm. 2006 Dec;113(12):1903-8. Epub 2006 Jun 6.
PMID 16752048
 
Osteopenia in Siah1a mutant mice.
Frew IJ, Sims NA, Quinn JM, Walkley CR, Purton LE, Bowtell DD, Gillespie MT.
J Biol Chem. 2004 Jul 9;279(28):29583-8. Epub 2004 May 3.
PMID 15123657
 
SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.
Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F.
Oncogene. 2000 Dec 7;19(52):5997-6006.
PMID 11146551
 
SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.
Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H.
Oncogene. 2003 Dec 4;22(55):8845-51.
PMID 14654780
 
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.
Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A.
Nat Cell Biol. 2005 Jul;7(7):665-74. Epub 2005 Jun 12.
PMID 15951807
 
Siah1 proteins enhance radiosensitivity of human breast cancer cells.
He HT, Fokas E, You A, Engenhart-Cabillic R, An HX.
BMC Cancer. 2010 Aug 3;10:403. doi: 10.1186/1471-2407-10-403.
PMID 20682032
 
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER.
Genes Dev. 1997 Oct 15;11(20):2701-14.
PMID 9334332
 
Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer.
Jansen MP, Ruigrok-Ritstier K, Dorssers LC, van Staveren IL, Look MP, Meijer-van Gelder ME, Sieuwerts AM, Helleman J, Sleijfer S, Klijn JG, Foekens JA, Berns EM.
Breast Cancer Res Treat. 2009 Jul;116(2):263-71. doi: 10.1007/s10549-008-0125-z. Epub 2008 Jul 16.
PMID 18629630
 
Inactivating mutations of the Siah-1 gene in gastric cancer.
Kim CJ, Cho YG, Park CH, Jeong SW, Nam SW, Kim SY, Lee SH, Yoo NJ, Lee JY, Park WS.
Oncogene. 2004 Nov 11;23(53):8591-6.
PMID 15467739
 
Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
Kramer OH, Muller S, Buchwald M, Reichardt S, Heinzel T.
FASEB J. 2008 May;22(5):1369-79. Epub 2007 Dec 11.
PMID 18073335
 
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.
Lee JT, Wheeler TC, Li L, Chin LS.
Hum Mol Genet. 2008 Mar 15;17(6):906-17. Epub 2007 Dec 7.
PMID 18065497
 
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N.
Mol Cell. 2001 May;7(5):927-36.
PMID 11389840
 
SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas.
Matsuo K, Satoh S, Okabe H, Nomura A, Maeda T, Yamaoka Y, Ikai I.
Genes Chromosomes Cancer. 2003 Mar;36(3):283-91.
PMID 12557228
 
Siah-1 facilitates ubiquitination and degradation of synphilin-1.
Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M.
J Biol Chem. 2003 Dec 19;278(51):51504-14. Epub 2003 Sep 23.
PMID 14506261
 
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.
Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H, Roperch JP, Tuynder M, Bougueleret L, Cherif D, Medhioub M, Pasturaud P, Alvaro V, der Sarkissan H, Cazes L, Le Paslier D, Le Gall I, Israeli D, Dausset J, Sigaux F, Chumakov I, Oren M, Calvo F, Amson RB, Cohen D, Telerman A.
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9039-42.
PMID 8799150
 
Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.
Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y.
Cancer Res. 2003 Jun 15;63(12):3043-8.
PMID 12810624
 
Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.
Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S.
J Biol Chem. 2008 Feb 8;283(6):3316-28. Epub 2007 Dec 10.
PMID 18070888
 
New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase.
Sirover MA.
Biochim Biophys Acta. 1999 Jul 13;1432(2):159-84.
PMID 10407139
 
p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.
Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, Nakai A, Matsuzawa S, Reed JC, Ishii S.
J Biol Chem. 2000 May 19;275(20):15578-85.
PMID 10747903
 
The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.
Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P.
EMBO J. 2001 Aug 1;20(15):4143-52.
PMID 11483517
 
SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells.
Wen YY, Yang ZQ, Song M, Li BL, Zhu JJ, Wang EH.
Cancer Sci. 2010b Jan;101(1):73-9. doi: 10.1111/j.1349-7006.2009.01339.x. Epub 2009 Sep 2.
PMID 19775288
 
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
Winter M, Sombroek D, Dauth I, Moehlenbrink J, Scheuermann K, Crone J, Hofmann TG.
Nat Cell Biol. 2008 Jul;10(7):812-24. doi: 10.1038/ncb1743. Epub 2008 Jun 8.
PMID 18536714
 
Proteasomal regulation of nuclear receptor corepressor-mediated repression.
Zhang J, Guenther MG, Carthew RW, Lazar MA.
Genes Dev. 1998 Jun 15;12(12):1775-80.
PMID 9637679
 

Citation

This paper should be referenced as such :
Nagano, Y ; Matsuzawa, SI
SIAH1 (siah E3 ubiquitin protein ligase 1)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(7):487-490.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/SIAH1ID457ch16q12.html


External links

Nomenclature
HGNC (Hugo)SIAH1   10857
Cards
AtlasSIAH1ID457ch16q12
Entrez_Gene (NCBI)SIAH1  6477  siah E3 ubiquitin protein ligase 1
AliasesSIAH1A
GeneCards (Weizmann)SIAH1
Ensembl hg19 (Hinxton)ENSG00000196470 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196470 [Gene_View]  chr16:48360536-48365873 [Contig_View]  SIAH1 [Vega]
ICGC DataPortalENSG00000196470
TCGA cBioPortalSIAH1
AceView (NCBI)SIAH1
Genatlas (Paris)SIAH1
WikiGenes6477
SOURCE (Princeton)SIAH1
Genetics Home Reference (NIH)SIAH1
Genomic and cartography
GoldenPath hg38 (UCSC)SIAH1  -     chr16:48360536-48365873 -  16q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIAH1  -     16q12.1   [Description]    (hg19-Feb_2009)
EnsemblSIAH1 - 16q12.1 [CytoView hg19]  SIAH1 - 16q12.1 [CytoView hg38]
Mapping of homologs : NCBISIAH1 [Mapview hg19]  SIAH1 [Mapview hg38]
OMIM602212   
Gene and transcription
Genbank (Entrez)AB451253 AB451377 AK023458 AK094663 AK225895
RefSeq transcript (Entrez)NM_001006610 NM_003031
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIAH1
Cluster EST : UnigeneHs.706828 [ NCBI ]
CGAP (NCI)Hs.706828
Alternative Splicing GalleryENSG00000196470
Gene ExpressionSIAH1 [ NCBI-GEO ]   SIAH1 [ EBI - ARRAY_EXPRESS ]   SIAH1 [ SEEK ]   SIAH1 [ MEM ]
Gene Expression Viewer (FireBrowse)SIAH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6477
GTEX Portal (Tissue expression)SIAH1
Human Protein AtlasENSG00000196470-SIAH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUQ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUQ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUQ4
Splice isoforms : SwissVarQ8IUQ4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ8IUQ4
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)    ZF_SIAH (PS51081)   
Domains : Interpro (EBI)7-in-absentia-prot_TRAF-dom    SIAH-type    SINA-like    TRAF-like    Znf_RING    Znf_RING/FYVE/PHD    Znf_SIAH   
Domain families : Pfam (Sanger)Sina (PF03145)   
Domain families : Pfam (NCBI)pfam03145   
Conserved Domain (NCBI)SIAH1
DMDM Disease mutations6477
Blocks (Seattle)SIAH1
PDB (SRS)2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
PDB (PDBSum)2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
PDB (IMB)2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
PDB (RSDB)2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
Structural Biology KnowledgeBase2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
SCOP (Structural Classification of Proteins)2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
CATH (Classification of proteins structures)2A25    4C9Z    4CA1    4I7B    4I7C    4I7D    4X3G   
SuperfamilyQ8IUQ4
Human Protein Atlas [tissue]ENSG00000196470-SIAH1 [tissue]
Peptide AtlasQ8IUQ4
HPRD03736
IPIIPI00396517   IPI00328242   IPI00872574   IPI00983168   IPI00640013   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUQ4
IntAct (EBI)Q8IUQ4
FunCoupENSG00000196470
BioGRIDSIAH1
STRING (EMBL)SIAH1
ZODIACSIAH1
Ontologies - Pathways
QuickGOQ8IUQ4
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  early endosome  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  apoptotic process  cell cycle  spermatogenesis  nervous system development  axon guidance  protein C-terminus binding  zinc ion binding  zinc ion binding  anatomical structure morphogenesis  protein catabolic process  beta-catenin destruction complex  protein destabilization  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  positive regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  cellular protein metabolic process  neuron apoptotic process  ubiquitin protein ligase activity  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  early endosome  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  apoptotic process  cell cycle  spermatogenesis  nervous system development  axon guidance  protein C-terminus binding  zinc ion binding  zinc ion binding  anatomical structure morphogenesis  protein catabolic process  beta-catenin destruction complex  protein destabilization  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  positive regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  cellular protein metabolic process  neuron apoptotic process  ubiquitin protein ligase activity  positive regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGp53 signaling pathway    Ubiquitin mediated proteolysis    Wnt signaling pathway   
REACTOMEQ8IUQ4 [protein]
REACTOME PathwaysR-HSA-983168 [pathway]   
NDEx NetworkSIAH1
Atlas of Cancer Signalling NetworkSIAH1
Wikipedia pathwaysSIAH1
Orthology - Evolution
OrthoDB6477
GeneTree (enSembl)ENSG00000196470
Phylogenetic Trees/Animal Genes : TreeFamSIAH1
HOVERGENQ8IUQ4
HOGENOMQ8IUQ4
Homologs : HomoloGeneSIAH1
Homology/Alignments : Family Browser (UCSC)SIAH1
Gene fusions - Rearrangements
Fusion : MitelmanPCYT1B/SIAH1 [Xp22.11/16q12.1]  [t(X;16)(p22;q12)]  
Fusion: TCGA_MDACCPCYT1B Xp22.11 SIAH1 16q12.1 LGG
Tumor Fusion PortalSIAH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIAH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIAH1
dbVarSIAH1
ClinVarSIAH1
1000_GenomesSIAH1 
Exome Variant ServerSIAH1
ExAC (Exome Aggregation Consortium)ENSG00000196470
GNOMAD BrowserENSG00000196470
Genetic variants : HAPMAP6477
Genomic Variants (DGV)SIAH1 [DGVbeta]
DECIPHERSIAH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIAH1 
Mutations
ICGC Data PortalSIAH1 
TCGA Data PortalSIAH1 
Broad Tumor PortalSIAH1
OASIS PortalSIAH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIAH1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIAH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIAH1
DgiDB (Drug Gene Interaction Database)SIAH1
DoCM (Curated mutations)SIAH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIAH1 (select a term)
intoGenSIAH1
NCG5 (London)SIAH1
Cancer3DSIAH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602212   
Orphanet
DisGeNETSIAH1
MedgenSIAH1
Genetic Testing Registry SIAH1
NextProtQ8IUQ4 [Medical]
TSGene6477
GENETestsSIAH1
Target ValidationSIAH1
Huge Navigator SIAH1 [HugePedia]
snp3D : Map Gene to Disease6477
BioCentury BCIQSIAH1
ClinGenSIAH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6477
Chemical/Pharm GKB GenePA35759
Clinical trialSIAH1
Miscellaneous
canSAR (ICR)SIAH1 (select the gene name)
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIAH1
EVEXSIAH1
GoPubMedSIAH1
iHOPSIAH1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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