Centre for Cellular, Molecular Biology, Uppal Road, Hyderabad - 500 007, India
Knockout phenotype: - Knockout mice show embryonic lethality with C3G-/- homozygous animals dying before embryonic day 7.5. Fibroblasts from knockout animals show impaired cell adhesion, delayed cell spreading and accelerated cell migration. - Animals expressing hypomorphic allele of C3G show overproliferation of the cortical neuroepithelium, cortical neuron migration defects, and defects in blood vessel maturation.
NCBI: 2889 MIM: 600303 HGNC: 4568 Ensembl: ENSG00000107263
dbSNP: 2889 ClinVar: 2889 TCGA: ENSG00000107263 COSMIC: RAPGEF1
Aninda Mitra ; Vegesna Radha
RAPGEF1 (Rap guanine nucleotide exchange factor (GEF) 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-07-01
Online version: http://atlasgeneticsoncology.org/gene/42045/css/tumors-explorer/img/logo-atlas-4.svg