1.Cytogénétique Hématologique, Service dHématologie Biologique, Hpital Pitié-Salpêtrière, APHP,.Sorbonne Université. Centre de Recherche des Cordeliers, INSERM UMRS_1138, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Paris, France elise.chapiro@aphp.fr; florence.nguyen-khac@psl.aphp.fr (EC, FNK), Laboratoire dHématologie, Hpital Robert Debré, Reims, France bgaillard@chu-reims.fr (BG)2.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Translocations involving the CDK6 gene are rare but recurrent abnormalities in mature B-cell neoplasms, mainly marginal zone lymphoma and chronic lymphocytic leukemia. Four different translocations have been described: t(2;7)(p11;q21) (the most frequent), t(7;14)(q21;q32), t(7;14)(q21;q11) and t(7;22)(q21;q11), leading to juxtaposition of the CDK6 gene with the IGK, IGH, TRA or IGL locus, respectively, and thus CDK6 overexpression.
Elise Chapiro ; Elise Chapiro ; Elise Chapiro
t(2;7)(p11;q21) IGK/CDK6t(7;14)(q21;q32) IGH/CDK6t(7;22)(q21;q11) IGL/CDK6
Atlas Genet Cytogenet Oncol Haematol. 2021-02-01
Online version: http://atlasgeneticsoncology.org/haematological/1361/t(7;22)(q21;q11)
2009-02-01 t(2;7)(p11;q21) IGK/CDK6t(7;14)(q21;q32) IGH/CDK6t(7;22)(q21;q11) IGL/CDK6 by Jean-Loup Huret  Affiliation